Some parts of the human body are renewed throughout life. If we could harness their regenerative mechanisms or properties and apply them to the parts that don\u2019t, we\u2019d make huge steps towards achieving new therapies for many injuries and diseases. The olfactory system is one such area that can renew itself, and it does this by using olfactory ensheathing cells (OECs) to guide newly formed axons \u2013 long, slender projections of nerve cells \u2013 towards the body\u2019s central nervous system.<\/p>\n
As a result, OECs have already been transplanted to see if this ability also works to promote axonal regeneration in spinal cord injuries and neural diseases; but in this environment, researchers have come across a hurdle. OECs need to move or migrate homogeneously and cohesively in order to be able to perform their task of guiding the axons, but factors in the spine area affect their behaviour so that they move individually or in the wrong direction.<\/p>\n
Now, in a study published this week in the journal Cellular and Molecular Life Sciences, IBEC researchers demonstrate that particular proteins are responsible for blocking the correct migration of OECs in the spine, therefore stopping them from performing the important task of guiding the young axons. If these proteins can be inhibited, the OECs could perform in the \u2018correct\u2019 way, as they do in the olfactory system, and aid axonal growth.<\/p>\n
\u201cWe took rodent OECs, and used cell tracking and traction force microscopy to analyze OEC migration and its mechanical properties over myelin, an insulating material around axons in the brain and central nervous system,\u201d explains Jos\u00e9 Antonio del R\u00edo, a group leader at IBEC. \u201cThe results show that these cells express all the components of what\u2019s called the Nogo receptor complex, a combination of receptors used by myelin to inhibit the movement of the OECs, and that inhibiting Nogo with a protein called NEP1-40 enhances their migratory capacity again.\u201d<\/p>\n