{"id":112689,"date":"2023-11-21T10:14:53","date_gmt":"2023-11-21T09:14:53","guid":{"rendered":"https:\/\/ibecbarcelona.eu\/luminescent-nanoparticle-based-implants-for-pain-and-epilepsy-treatment\/"},"modified":"2023-11-21T10:31:50","modified_gmt":"2023-11-21T09:31:50","slug":"luminescent-nanoparticle-based-implants-for-pain-and-epilepsy-treatment","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/es\/implantes-con-nanoparticulas-luminiscentes-para-tratar-el-dolor-y-la-epilepsia","title":{"rendered":"Implantes con nanopart\u00edculas luminiscentes para tratar el dolor y la epilepsia"},"content":{"rendered":"\n

El IBEC coordinar\u00e1 el proyecto PHOTOTHERAPORT que se desarrollar\u00e1 con la financiaci\u00f3n del programa Pathfinder Open del Consejo de Innovaci\u00f3n Europeo.<\/strong> El proyecto se centra en el desarrollo de implantes luminiscentes y f\u00e1rmacos activados con luz para innovadoras terapias de neuromodulaci\u00f3n.<\/strong> Phototheraport ser\u00e1 un consorcio internacional de 8 instituciones y recibir\u00e1 3 millones de euros en 3 a\u00f1os para el estudio precl\u00ednico de estos implantes.<\/strong><\/p>\n\n\n\n

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Pau Gorostiza, profesor de investigaci\u00f3n ICREA e investigador principal del grupo de Nanosondas y Nanoconmutadores<\/a> del Instituto de bioingenier\u00eda de Catalu\u00f1a (IBEC) y del CIBER-BBN, coordinar\u00e1 el proyecto PHOTOTHERAPORT financiado por el prestigioso programa Pathfinder Open del Consejo de Innovaci\u00f3n Europeo (EIC, por sus siglas en ingl\u00e9s). Con esta iniciativa el EIC impulsa la exploraci\u00f3n de ideas atrevidas para tecnolog\u00edas radicalmente nuevas, apoyando colaboraciones cient\u00edficas de vanguardia, interdisciplinarias y de alto riesgo\/alta recompensa que sustentan avances tecnol\u00f3gicos.<\/p>\n\n\n\n

PHOTOTHERAPORT se centra en el desarrollo de implantes luminiscentes como puertos para terapias de luz, en analog\u00eda a los que se emplean en quimioterapia para administrar f\u00e1rmacos. Un consorcio de 8 instituciones de 4 pa\u00edses, coordinado por el IBEC, llevar\u00e1 a cabo el proyecto con una financiaci\u00f3n de 3 millones de euros durante los pr\u00f3ximos 3 a\u00f1os.<\/p>\n\n\n\n

Las terapias basadas en la luz est\u00e1n cobrando importancia en medicina debido a su capacidad para dirigirse a regiones espec\u00edficas del cuerpo. A pesar de su demostrado potencial terap\u00e9utico, estas terapias se enfrentan a un desaf\u00edo com\u00fan: la atenuaci\u00f3n de la luz visible a trav\u00e9s de tejidos blandos y huesos antes de que llegue de manera efectiva al lugar de inter\u00e9s. Esta atenuaci\u00f3n es mayor cuanto m\u00e1s profundos son los tejidos y \u00f3rganos que se pretende alcanzar.<\/p>\n\n\n\n

La plataforma PhotoTheraPort ofrece una soluci\u00f3n a este desaf\u00edo. Se trata de unos implantes dise\u00f1ados para que emitan luz localmente al iluminarlos con una fuente de luz externa. Estos dispositivos incorporan nanopart\u00edculas de upconversion<\/em> (conversi\u00f3n ascendente, en ingl\u00e9s), que al iluminarlas con luz infrarroja emiten fotones de mayor energ\u00eda (luz visible o ultravioleta). De este modo, la emisi\u00f3n de luz por parte de las nanopart\u00edculas se puede controlar de forma remota y no invasiva, aplicando externamente luz infrarroja, que s\u00ed penetra a trav\u00e9s del tejido y el hueso. La forma y el color de emisi\u00f3n de los PhotoTheraPorts podr\u00e1n ajustarse a diversos prop\u00f3sitos terap\u00e9uticos. El consorcio de investigaci\u00f3n emplear\u00e1 inicialmente esta plataforma para producir efectos analg\u00e9sicos \u00fanicamente mediante luz, lo que se conoce c\u00f3mo fotobiomodulaci\u00f3n contra el dolor, y lo comparar\u00e1n con l\u00e1mparas que ya se utilizan cl\u00ednicamente. El prop\u00f3sito es tratar el dolor inflamatorio de manera m\u00e1s efectiva en regiones ocultas de la columna vertebral.<\/p>\n\n\n\n

A continuaci\u00f3n, los PhotoTheraPort se aplicar\u00e1n a terapias de neuromodulaci\u00f3n fotofarmacol\u00f3gica. Para ello se desarrollar\u00e1n fotof\u00e1rmacos dise\u00f1ados para trabajar juntamente con la plataforma de emisores de luz. Estos f\u00e1rmacos se activan \u00fanicamente cuando se exponen a un color de luz espec\u00edfico. Esta segunda tecnolog\u00eda se probar\u00e1 para reducir el dolor neurop\u00e1tico iluminando en ciertas regiones de la columna vertebral. Tambi\u00e9n se intentar\u00e1 inhibir la hiperactividad neuronal caracter\u00edstica de la epilepsia focal, que afecta a una zona limitada del cerebro y es intratable en el 30% de pacientes epil\u00e9pticos.<\/p>\n\n\n\n

\n

\u201cNuestra meta es demostrar, dentro de cinco a\u00f1os, la seguridad y no toxicidad de la plataforma y acercar esta nueva terapia de fotobiomodulaci\u00f3n al uso cl\u00ednico. Los plazos de desarrollo de los fotof\u00e1rmacos son impredecibles, pero se prev\u00e9n m\u00e1s largos. Si obtenemos buenos resultados precl\u00ednicos para la neuromodulaci\u00f3n, ser\u00eda la primera mol\u00e9cula de este tipo que cumpla con los requisitos regulatorios.\u201d explica Gorostiza.<\/p>\n<\/blockquote>\n\n\n\n

Una vez probada la eficacia de los PhotoTheraPort para estas patolog\u00edas, la plataforma tiene el potencial de poder aplicarse a otras condiciones que requieren de tratamientos con acci\u00f3n localizada, como son la artritis, las enfermedades autoinmunes, las infecciones o los trasplantes. La simplicidad y versatilidad de esta innovadora plataforma pretende mejorar el tratamiento del dolor y la calidad de vida de los pacientes, adem\u00e1s de ofrecer al sistema sanitario formas de optimizar costes m\u00e9dicos y ampliar sus beneficios.<\/p>\n\n\n\n

El consorcio PHOTOTHERAPORT est\u00e1 formado por el Instituto Let\u00f3n de S\u00edntesis Org\u00e1nica, la Universidad de Tampere (Finlandia), el instituto de Tecnolog\u00eda Technion (Israel), la Universidad Stradins de Riga (Letonia), la Universidad de C\u00e1diz, el Instituto de Investigaciones Biom\u00e9dicas de Barcelona (IIBB-CSIC) y el Instituto Teamit, y est\u00e1 coordinado por el IBEC.<\/p>\n\n\n\n

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El IBEC coordinar\u00e1 el proyecto PHOTOTHERAPORT que se desarrollar\u00e1 con la financiaci\u00f3n del programa Pathfinder Open del Consejo de Innovaci\u00f3n Europeo. El proyecto se centra en el desarrollo de implantes luminiscentes y f\u00e1rmacos activados con luz para innovadoras terapias de neuromodulaci\u00f3n. Phototheraport ser\u00e1 un consorcio internacional de 8 instituciones y recibir\u00e1 3 millones de euros en 3 a\u00f1os para el estudio precl\u00ednico de estos implantes. <\/p>\n","protected":false},"author":37,"featured_media":112680,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[94],"tags":[2074,1882,1884],"post_formats":[],"class_list":["post-112689","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias-institucionales","tag-epilepsy-es","tag-nanoprobes-and-nanoswitches-es","tag-pau-gorostiza-es-2"],"yoast_head":"\nImplantes luminiscentes para tratar el dolor y la epilepsia - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"description\" content=\"El IBEC coordinar\u00e1 el proyecto PHOTOTHERAPORT, financiado por el programa Pathfinder Open del Consejo de Innovaci\u00f3n Europeo (EIC).\" \/>\n<meta name=\"robots\" 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