{"id":112801,"date":"2023-11-23T12:00:00","date_gmt":"2023-11-23T11:00:00","guid":{"rendered":"https:\/\/ibecbarcelona.eu\/?p=112801"},"modified":"2023-11-23T10:54:31","modified_gmt":"2023-11-23T09:54:31","slug":"benedetta-bolognesi-awarded-a-prestigious-european-erc-consolidator-grant","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/es\/benedetta-bolognesi-galardonada-con-una-prestigiosa-beca-europea-erc-consolidator-grant","title":{"rendered":"La investigadora Benedetta Bolognesi galardonada con una prestigiosa beca europea ERC Consolidator Grant"},"content":{"rendered":"\n<p><span><b>La investigadora del I<\/b><\/span><strong>BEC<\/strong><span><b> ha sido galardonada con una \u00abERC Consolidator Grant\u00bb. Esta prestigiosa financiaci\u00f3n europea respalda a cient\u00edficos en la etapa de consolidaci\u00f3n de sus equipos de investigaci\u00f3n, permiti\u00e9ndoles perseguir ideas cient\u00edficas innovadoras. 2 millones de euros durante 5 a\u00f1os permitir\u00e1n a Bolognesi y su equipo desarrollar un nuevo m\u00e9todo para identificar<\/b><\/span><strong> las mutaciones que conducen a la formaci\u00f3n de amiloides, agregados de prote\u00ednas que causan multitud de enfermedades, incluyendo el Alzheimer o el Parkinson.<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" data-src=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2023\/11\/0M0A7151-low-1024x683.jpg\" alt=\"\" class=\"wp-image-112810 lazyload\" data-srcset=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2023\/11\/0M0A7151-low-1024x683.jpg 1024w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2023\/11\/0M0A7151-low-300x200.jpg 300w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2023\/11\/0M0A7151-low-768x512.jpg 768w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2023\/11\/0M0A7151-low-600x400.jpg 600w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2023\/11\/0M0A7151-low.jpg 1200w\" data-sizes=\"(max-width: 1024px) 100vw, 1024px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 1024px; --smush-placeholder-aspect-ratio: 1024\/683;\" \/><\/figure>\n\n\n\n<p>Benedetta Bolognesi, investigadora principal en el IBEC ha sido galardonada con una \u00abERC Consolidator Grant\u00bb, una de las fuentes de financiaci\u00f3n m\u00e1s prestigiosas y competitivas de la Uni\u00f3n Europea. Se trata de una ayuda a la investigaci\u00f3n otorgada por el Consejo de Investigaci\u00f3n Europeo (ERC) que respalda a personal cient\u00edfico y acad\u00e9mico destacado en la etapa de sus carreras en la que a\u00fan est\u00e1n consolidando sus propios equipos de investigaci\u00f3n independientes para que puedan perseguir sus ideas cient\u00edficas m\u00e1s prometedoras.<\/p>\n\n\n\n<p>Bolognesi forma parte del selecto 14,5% de candidatos galardonados en toda Europa de entre las 2.130 solicitudes que se recibieron en esta convocatoria.<\/p>\n\n\n\n<p>La investigadora inici\u00f3 su andadura como l\u00edder de grupo a finales de 2018, con la creaci\u00f3n del grupo de <a href=\"https:\/\/ibecbarcelona.eu\/protein-phase-transitions-in-health-and-disease\/\">Transiciones de Fase de Prote\u00ednas en la Salud y la Enfermedad<\/a> del IBEC. Tras cuatro a\u00f1os como l\u00edder de grupo junior, estabiliz\u00f3 su plaza como l\u00edder de grupo consolidada.<\/p>\n\n\n\n<p>El proyecto que desarrollar\u00e1 gracias a esta nueva financiaci\u00f3n lleva por nombre Mapeo Global de Amiloides: Resolviendo la Nucleaci\u00f3n Amiloide mediante Mutag\u00e9nesis Profunda (GLAM-Map, por sus siglas en ingl\u00e9s).<\/p>\n\n\n\n<p>Los amiloides son prote\u00ednas que forman agregados o fibrillas que se acumulan en el organismo, sin que \u00e9ste sea capaz de descomponerlas. Su presencia y proceso de formaci\u00f3n parecen ser la causa de m\u00e1s de 50 enfermedades humanas, incluidas la enfermedad de Alzheimer, la enfermedad de Parkinson, la demencia frontotemporal, la esclerosis lateral amiotr\u00f3fica (ELA) y la diabetes tipo II.<\/p>\n\n\n\n<p>En el proceso de formaci\u00f3n de amiloides, las prote\u00ednas atraviesan un estado de transici\u00f3n antes de adoptar su conformaci\u00f3n final, en la que acaban formando agregados. Este estado intermedio es crucial para comprender la evoluci\u00f3n de la prote\u00edna hacia su estructura amiloide. Sin embargo, estudiar este estado es particularmente desafiante con los m\u00e9todos convencionales debido a su breve duraci\u00f3n.<\/p>\n\n\n\n<p>Como alternativa para estudiar este proceso, Benedetta y su equipo han desarrollado una nueva metodolog\u00eda basada en la t\u00e9cnica de escaneo mutacional profundo. Con ella, se introducen mutaciones en miles de secuencias de prote\u00ednas para estudiar sus efectos en la tasa de agregaci\u00f3n.<\/p>\n\n\n\n<p>El proyecto tiene tres objetivos principales: &nbsp;mapear el impacto de mutaciones en m\u00e1s de 60 amiloides, construir modelos de estados de transici\u00f3n de amiloides asociados a enfermedades, y descubrir secuencias gen\u00e9ticas que inician la formaci\u00f3n de amiloides en respuesta al estr\u00e9s ambiental.<\/p>\n\n\n\n<p>Este proyecto busca desentra\u00f1ar las reglas que rigen la formaci\u00f3n de amiloides, identificar mutaciones que aceleran la agregaci\u00f3n y causan enfermedades, y comprender los estados de transici\u00f3n de este proceso.<\/p>\n\n\n\n<p>Se espera que los resultados contribuyan al desarrollo de nuevos enfoques terap\u00e9uticos para enfermedades amiloides, incluyendo demencias severas. M\u00e1s a\u00fan, los resultados podr\u00e1n alimentar nuevos modelos y predictores de agregaci\u00f3n de prote\u00ednas para interpretar variantes gen\u00e9ticas de las enfermedades y dise\u00f1ar prote\u00ednas sint\u00e9ticas innovadoras.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>La investigadora del IBEC ha sido galardonada con una \u00abERC Consolidator Grant\u00bb. Esta prestigiosa financiaci\u00f3n europea respalda a cient\u00edficos en la etapa de consolidaci\u00f3n de sus equipos de investigaci\u00f3n, permiti\u00e9ndoles perseguir ideas cient\u00edficas innovadoras. 2 millones de euros durante 5 a\u00f1os permitir\u00e1n a Bolognesi y su equipo desarrollar un nuevo m\u00e9todo para identificar las mutaciones que conducen a la formaci\u00f3n de amiloides, agregados de prote\u00ednas que causan multitud de enfermedades, incluyendo el Alzheimer o el Parkinson.<\/p>\n","protected":false},"author":37,"featured_media":112810,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[94],"tags":[1628,1108,2062,1819,1777],"post_formats":[],"class_list":["post-112801","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias-institucionales","tag-alzheimer-es-2","tag-benedetta-bolognesi-es","tag-erc-es","tag-premio","tag-protein-phase-transitions-in-health-and-disease-es"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Benedetta Bolognesi galardonada con una ERC Consolidator Grant - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"description\" content=\"Bolognesi desarrollar\u00e1 un nuevo m\u00e9todo para identificar las mutaciones que conducen a la formaci\u00f3n de amiloides, implicados en el Parkinson y 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