{"id":11586,"date":"2009-10-23T16:46:08","date_gmt":"2009-10-23T16:46:08","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/new\/?p=11586"},"modified":"2015-01-15T16:46:54","modified_gmt":"2015-01-15T16:46:54","slug":"es-descobreix-un-nou-mecanisme-en-el-proces-dadhesio-cel%c2%b7lular","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/es\/es-descobreix-un-nou-mecanisme-en-el-proces-dadhesio-cel%c2%b7lular\/","title":{"rendered":"(Es descobreix un nou mecanisme en el proc\u00e9s d\u2019adhesi\u00f3 cel\u00b7lular)"},"content":{"rendered":"

Aquests processos estan controlats en gran mesura per la integrina LFA-1 (ant\u00edgen-1 de funci\u00f3 associada de linfocit). Estudis anteriors apuntaven que l\u2019adhesi\u00f3 era estable quan hi havia plataformes lip\u00eddiques en les que s\u2019organitzaven prote\u00efnes de la membrana cel\u00b7ular, entre elles prote\u00efnes d\u2019ancoratge de membrana GPI (glicosilfosfatidilinositol). Per\u00f2 hi ha hagut una gran controv\u00e8rsia sobre l\u2019exist\u00e8ncia d\u2019aquestes plataformes. Al ser molt petites (nanom\u00e8triques) no es podien veure i no es coneixia la funci\u00f3 que realitzaven en el proc\u00e9s d\u2019adhesi\u00f3.<\/p>\n

Imatge: la integrina LFA-1 (punts vermells) i les prote\u00efnes d\u2019ancoratge de membrana GPI (verd) a la membrana d\u2019una c\u00e8l\u00b7ula del sistema immunol\u00f2gic. La imatge ha estat realitzada amb un microscopi \u00f2ptic de superresoluci\u00f3.<\/h6>\n

Un equip d\u2019investigadors de l\u2019\u00e0rea de Bionanofot\u00f2nica, del Institut de Bioenginyeria de Catalunya (IBEC), dirigits per Mar\u00eda Garc\u00eda-Parajo, ha aconseguit veure aquestes plataformes lip\u00eddiques i ha descobert que en el proc\u00e9s d\u2019adhesi\u00f3 cel\u00b7ular, aquestes plataformes s\u2019organitzen al voltant de les prote\u00efnes GPI i a prop de la LFA-1. Les prote\u00efnes activen la LFA-1, aix\u00ed com assisteixen en tot el proc\u00e9s d\u2019adhesi\u00f3 i migraci\u00f3 de les c\u00e8l\u00b7ules del sistema immunol\u00f2gic.<\/p>\n

Aquests resultats han estat possibles gr\u00e0cies a una t\u00e8cnica de superresoluci\u00f3 \u00f2ptica en camp proper (NSOM, sigles en angl\u00e8s) que permet treballar a escala nanom\u00e8trica i que l\u2019equip de l\u2019IBEC ha adaptat per treballar amb mostres biol\u00f2giques, c\u00e8l\u00b7ules i processos biol\u00f2gics en el seu estat natural. Els resultats obtinguts s\u2019han publicat a la revista Proceedings of the National Academy of Sciences<\/a> (PNAS), en un article que ja est\u00e0 disponible en l\u00ednia.<\/p>\n

L\u2019organitzaci\u00f3 de les prote\u00efnes i la interacci\u00f3 de les c\u00e8l\u00b7ules del sistema immunol\u00f2gic en el proc\u00e9s d\u2019adhesi\u00f3 explica moltes de les malalties autoimmunes, al\u00b7\u00e8rgies i la transmissi\u00f3 r\u00e0pida del VIH, que es produeixen per una incorrecta o abs\u00e8ncia d\u2019adhesi\u00f3. Els descobriments que es realitzen en aquest sentit, com el de l\u2019equip de l\u2019IBEC, amplien les possibilitats de dissenyar noves ter\u00e0pies per a aquestes malalties.<\/p>\n

Els resultats obtinguts i la tecnologia disponible obren tamb\u00e9 la possibilitat d\u2019explorar altres \u00e0mbits en biologia cel\u00b7ular amb imatges a la nanoescala, ja que l\u2019organitzaci\u00f3 de prote\u00efnes a la membrana cel\u00b7ular \u00e9s un mecanisme general de resposta r\u00e0pida a l\u2019entorn. En concret, podrien explicar processos d\u2019adhesi\u00f3 que realitzen altres integrines en els que tamb\u00e9 hi ha interacci\u00f3 amb plataformes lip\u00eddiques.<\/p>\n

—<\/p>\n

Article:<\/em><\/strong> Hotspots of GPI-anchored proteins and inegrin nanoclusters function as nucleation sites for cell adhesion<\/a>. Thomas S. van Zanten, Alessandra Cambi, Marjolein Koopman, Ben Joosten, Carl G. Figdor y Mar\u00eda F. Garc\u00eda-Parajo.<\/p>\n","protected":false},"excerpt":{"rendered":"

Un proc\u00e9s essencial del sistema immunol\u00f2gic per fer front a una infecci\u00f3 \u00e9s que les c\u00e8l\u00b7lules encarregades d\u2019identificar els agent infecciosos, c\u00e8l\u00b7lules dendr\u00edtiques, es comuniquen amb les que s\u2019ocupen de destruir-los, c\u00e8l\u00b7lules T. <\/h3>\n

Per a aix\u00f2, cal que les c\u00e8l\u00b7lules dendr\u00edtiques s\u2019activin correctament, migrin als n\u00f2duls linf\u00e0tics i s\u2019adhereixin fermament a les c\u00e8l\u00b7ules T.<\/p>\n","protected":false},"author":4,"featured_media":5190,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[97],"tags":[],"post_formats":[],"class_list":["post-11586","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias-de-investigacion"],"yoast_head":"\n(Es descobreix un nou mecanisme en el proc\u00e9s d\u2019adhesi\u00f3 cel\u00b7lular) - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/es\/es-descobreix-un-nou-mecanisme-en-el-proces-dadhesio-cel\u00b7lular\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"(Es descobreix un nou mecanisme en el proc\u00e9s d\u2019adhesi\u00f3 cel\u00b7lular) - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Un proc\u00e9s essencial del sistema immunol\u00f2gic per fer front a una infecci\u00f3 \u00e9s que les c\u00e8l\u00b7lules encarregades d\u2019identificar els agent infecciosos, c\u00e8l\u00b7lules dendr\u00edtiques, es comuniquen amb les que s\u2019ocupen de destruir-los, c\u00e8l\u00b7lules T. 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