{"id":11596,"date":"2009-09-22T16:58:50","date_gmt":"2009-09-22T16:58:50","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/new\/?p=11596"},"modified":"2015-01-15T16:59:37","modified_gmt":"2015-01-15T16:59:37","slug":"es-descobreix-la-diferencia-funcional-de-dues-integrines-de-lenllac-de-la-cel%c2%b7lula-amb-lentorn","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/es\/es-descobreix-la-diferencia-funcional-de-dues-integrines-de-lenllac-de-la-cel%c2%b7lula-amb-lentorn\/","title":{"rendered":"(Es descobreix la diferencia funcional de dues integrines de l\u2019enlla\u00e7 de la c\u00e8l\u00b7lula amb l&#8217;entorn)"},"content":{"rendered":"<p>Un <a href=\"http:\/\/www.pnas.org\/content\/early\/2009\/09\/02\/0902818106.full.pdf+html\" target=\"_blank\">article<\/a> publicat en l\u00ednia a Proceedings of the National Academy of Sciences (PNAS), l\u2019autor principal del qual \u00e9s Pere Roca-Cusachs, investigador de l\u2019IBEC, aporta per primera vegada una desposta experimental a aquesta q\u00fcesti\u00f3.<\/p>\n<p>A l\u2019article es mostra la difer\u00e8ncia funcional de les dues integrines i la seva complementarietat. La integrina \u03b1<sub>5<\/sub>\u03b2<sub>1<\/sub> \u00e9s la responsable de resistir les forces de l\u2019entorn cel\u00b7lular i alhora mantenir la integritat de l\u2019enlla\u00e7 entre les c\u00e8l\u00b7lules i el seu entorn. Per la seva part, la integrina \u03b1<sub>v<\/sub>\u03b2<sub>3<\/sub> s\u2019ocupa de la detecci\u00f3 de les forces, sense aportar cap resist\u00e8ncia addicional. Aquest descobriment confirma tamb\u00e9 la idea intu\u00eftiva de que la c\u00e8l\u00b7lula \u00e9s com una m\u00e0quina microsc\u00f2pica amb capacitat de detecci\u00f3 i resist\u00e8ncia per relacionar-se amb el seu entorn.<\/p>\n<p>L\u2019estudi s\u2019ha realitzat amb fibroblasts. En concret, s\u2019ha estudiat l\u2019adhesi\u00f3 de les dues integrines amb la fibronectina, una prote\u00efna essencial en l\u2019adhesi\u00f3 cel\u00b7lular, la curaci\u00f3 de ferides i l\u2019embriog\u00e8nesi. La comunicaci\u00f3 de la c\u00e8l\u00b7lula amb l\u2019entorn tamb\u00e9 \u00e9s un factor important en el desenvolupament de tumors, ja que un dels primers canvis que es detecten en un tumor \u00e9s l\u2019augment de rigidesa. A l\u2019augmentar la duresa de l\u2019entorn, la c\u00e8l\u00b7lula pot passar de comportar-se normalment a ser cancer\u00edgena. Actualment ja existeixen anticancer\u00edgens basats en la inhibici\u00f3 de les integrines. Entendre els mecanismes pels quals les integrines influeixen en la resposta de les c\u00e8l\u00b7lules d\u2019un teixit \u00e9s essencial per desenvolupar f\u00e0rmacs m\u00e9s espec\u00edfics i amb menys efectes secundaris. Aix\u00ed, la identificaci\u00f3 de la integrina \u03b1<sub>v<\/sub>\u03b2<sub>3<\/sub> com a detector de forces la situa com a candidata en el desenvolupament d\u2019anticancer\u00edgens, ja que podria explicar part del comportament maligne de tumors associats al canvi de rigidesa.<\/p>\n","protected":false},"excerpt":{"rendered":"<h3>La c\u00e8l\u00b7lula realitza l\u2019enlla\u00e7 amb els diferents components de l\u2019exterior principalment a trav\u00e9s d\u2019unes mol\u00e8cules anomenades integrines. <\/h3>\n<p>L\u2019enlla\u00e7 amb la fibronectina, present en la matriu extracel\u00b7lular, el realitzen dues integrines, la \u03b1<sub>5<\/sub>\u03b2<sub>1<\/sub> i la \u03b1<sub>v<\/sub>\u03b2<sub>3<\/sub>. Per\u00f2, per qu\u00e8 hi ha dues mol\u00e8cules per enlla\u00e7ar amb un mateix component extracel\u00b7lular? <\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[97],"tags":[],"post_formats":[],"class_list":["post-11596","post","type-post","status-publish","format-standard","hentry","category-noticias-de-investigacion"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>(Es descobreix la diferencia funcional de dues integrines de l\u2019enlla\u00e7 de la c\u00e8l\u00b7lula amb l&#039;entorn) - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/es\/es-descobreix-la-diferencia-funcional-de-dues-integrines-de-lenllac-de-la-cel\u00b7lula-amb-lentorn\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"(Es descobreix la diferencia funcional de dues integrines de l\u2019enlla\u00e7 de la c\u00e8l\u00b7lula amb l&#039;entorn) - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"La c\u00e8l\u00b7lula realitza l\u2019enlla\u00e7 amb els diferents components de l\u2019exterior principalment a trav\u00e9s d\u2019unes mol\u00e8cules anomenades integrines.  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