{"id":11615,"date":"2009-07-02T17:21:09","date_gmt":"2009-07-02T17:21:09","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/new\/?p=11615"},"modified":"2015-01-15T17:21:55","modified_gmt":"2015-01-15T17:21:55","slug":"troben-la-clau-de-lexit-dalguns-dels-bacteris-mes-virulents-2","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/es\/troben-la-clau-de-lexit-dalguns-dels-bacteris-mes-virulents-2\/","title":{"rendered":"(Troben la clau de l\u2019\u00e8xit d\u2019alguns dels bacteris m\u00e9s virulents)"},"content":{"rendered":"<p>[br]<\/p>\n<h6 class=\"caption\" style=\"width: 230px; float: left; padding: 0px 10px 10px 0px;\" >Trasmissi\u00f3 horitzonal de DNA entre dues c\u00e8l\u00b7lules del bacteri Escherichia coli. Imatge: Antonio Ju\u00e1rez (IBEC)<\/h6>\n<p>Investigadors de l\u2019Institut de Bioenginyeria de Catalunya (IBEC), de l\u2019Institut de Recerca Biom\u00e8dica (IRB Barcelona) i de la Universitat de Barcelona (UB), han descobert l\u2019estrat\u00e8gia que han adoptat els Enterobacteris per facilitar la incorporaci\u00f3 i la regulaci\u00f3 de gens que els atorguen resist\u00e8ncia i virul\u00e8ncia. El treball, publicat recentment a PLoS Genetics, obre la porta a la generaci\u00f3 de nous f\u00e0rmacs que permeti tractar en el futur infeccions causades per variants multiresistents de pat\u00f2gens com Escherichia coli, Salmonella o Shigella.<\/p>\n<p>Les bact\u00e8ries que pertanyen al grup dels Enterobacteris causen infeccions intestinals com disenteria i tifus, i extraintestinals com infeccions urin\u00e0ries, meningitis i s\u00e8psies. Molts dels gens relacionats amb la patogenicitat dels bacteris tenen la propietat de ser gens de transmissi\u00f3 horitzontal (HGT), que significa que poden ser transferits d\u2019una c\u00e8l\u00b7lula bacteriana a una altra, fins i tot a un individu d\u2019una esp\u00e8cie diferent, dins de la mateixa generaci\u00f3. \u00abEs com si el teu ve\u00ed et pogu\u00e9s passar gens que et fossin favorables en un determinat ambient\u00bb explica Miquel Pons, investigador de l\u2019IRB Barcelona i catedr\u00e0tic de la UB. L\u2019adquisici\u00f3 de DNA per transmissi\u00f3 horitzontal pot implicar l\u2019assoliment de noves propietats i, per tant, la capacitat d\u2019adaptaci\u00f3 a nous entorns. D\u2019entre aquestes propietats, destaquen la resist\u00e8ncia a antibi\u00f2tics i a d\u2019altres subst\u00e0ncies antimicrobianes, i factors de virul\u00e8ncia, \u00e9s a dir, els gens que possibiliten als bacteris causar malalties infeccioses.<\/p>\n<p>\u00abMalgrat la reconeguda import\u00e0ncia de la HGT en la variabilitat dels genomes bacterians, es coneixen poc els mecanismes que possibiliten que els nous fragments de DNA adquirits representin un benefici per a la c\u00e8l\u00b7lula receptora\u00bb diu el coordinador del treball, Antonio Ju\u00e1rez, investigador de l\u2019IBEC i catedr\u00e0tic de la UB expert en microbiologia. El nou treball evidencia que els Enterobacteris han desenvolupat un mecanisme per facilitar l\u2019adquisici\u00f3 de DNA de transmissi\u00f3 horitzontal que consisteix en la producci\u00f3 de dues prote\u00efnes, H-NS i Hha que, interaccionant entre elles i amb el DNA del bacteri, faciliten la integraci\u00f3 en la c\u00e8l\u00b7lula receptora del nou material gen\u00e8tic i el regulen espec\u00edficament. Els investigadors proposen que alterant la funci\u00f3 d\u2019aquestes dues prote\u00efnes, es podria interferir en l\u2019expressi\u00f3 de la virul\u00e8ncia i de la resist\u00e8ncia a antibi\u00f2tics, funcions que sovint resideixen en aquest tipus de material gen\u00e8tic. Ju\u00e1rez conclou que \u00abaquest treball obre una nova estrat\u00e8gia per combatre els bacteris, que no es basi en aniquilar-los sin\u00f3 en atacar i desactivar all\u00f2 que els fa perillosos\u00bb.<\/p>\n<p>&#8212;<\/p>\n<p><em><strong>Article de refer\u00e8ncia:<\/strong> <\/em>Differential Regulation of Horizontally Acquired and Core Genome Genes by the Bacterial Modulator H-NS. Rosa C. Ba\u00f1os, Aitziber Vivero, Sonia Aznar, Jes\u00fas Garc\u00eda, Miquel Pons, Cristina Madrid, Antonio Ju\u00e1rez. <em>PLoS Genetics<\/em> (June 2009), Vol 5, Issue 6, e1000513<br \/>\n<a href=\"http:\/\/www.plosgenetics.org\/doi\/pgen.1000513\">http:\/\/www.plosgenetics.org\/doi\/pgen.1000513<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<h3> <img decoding=\"async\" class=\"left size-full wp-image-5095 lazyload\" data-src=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2009\/07\/noticia-ecoli.jpg\" border=\"0\" width=\"150\" height=\"120\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 150px; --smush-placeholder-aspect-ratio: 150\/120;\" \/>  Investigadors de l\u2019IBEC, l\u2019IRB Barcelona i la UB identifiquen l\u2019estrat\u00e8gia que usen els Enterobacteris per adquirir resist\u00e8ncia i patogenicitat.<\/h3>\n<p>L\u2019augment d\u2019infeccions causades per bacteris multiresistents \u00e9s un problema creixent de salut p\u00fablica, sobretot en entorns hospitalaris, on la situaci\u00f3 \u00e9s greu. <\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[97],"tags":[],"post_formats":[],"class_list":["post-11615","post","type-post","status-publish","format-standard","hentry","category-noticias-de-investigacion"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>(Troben la clau de l\u2019\u00e8xit d\u2019alguns dels bacteris m\u00e9s virulents) - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/es\/troben-la-clau-de-lexit-dalguns-dels-bacteris-mes-virulents-2\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"(Troben la clau de l\u2019\u00e8xit d\u2019alguns dels bacteris m\u00e9s virulents) - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Investigadors de l\u2019IBEC, l\u2019IRB Barcelona i la UB identifiquen l\u2019estrat\u00e8gia que usen els Enterobacteris per adquirir resist\u00e8ncia i patogenicitat. 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