{"id":12175,"date":"2015-01-21T16:15:15","date_gmt":"2015-01-21T16:15:15","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/new\/?p=12175"},"modified":"2015-02-03T16:25:13","modified_gmt":"2015-02-03T16:25:13","slug":"se-identifica-un-actor-clave-en-las-infecciones-de-e-coli","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/es\/se-identifica-un-actor-clave-en-las-infecciones-de-e-coli\/","title":{"rendered":"Se identifica un actor clave en las infecciones de E. coli"},"content":{"rendered":"
Pie de foto: Microscop\u00eda electr\u00f3nica de la cepa LF82 de la adherente y invasiva E. coli (izquierda) y los mutantes nrdR (derecha) (ampliaci\u00f3n \u00c5~ 10,000).<\/h6>\n

En un art\u00edculo publicado recientemente en la revista American Society for Microbiology\u2019s Infection and Immunity, el grupo \u00abInfecciones Bacterianas: terapias antimicrobianas\u00bb del IBEC ha descubierto que la ribonucle\u00f3tido reductasa (RNRs) \u2013enzima que proporciona los bloques de construcci\u00f3n para la replicaci\u00f3n del ADN en las c\u00e9lulas vivas\u2013 juega un papel importante en la virulencia e infecci\u00f3n de la Escherichia coli.<\/p>\n

\u201cHemos examinado los papeles de diferentes clases de RNR durante la infecci\u00f3n por la enfermedad de Crohn \u2013asociada a la adherencia e invasi\u00f3n de la cepa de E. coli AIEX LF82\u2013\u201d dice Eduard Torrents, investigador principal j\u00fanior del IBEC. Utilizando c\u00e9lulas intestinales en un modelo de infecci\u00f3n in vivo y trabajando conjuntamente con un grupo de la Universidad de Auverge en Clermont-Ferrand, l\u00edderes mundiales en infecciones por E. coli, el grupo ha encontrado que inactivando o anulando la prote\u00edna NrdD y el regulador transcripcional NrdR, disminuye la habilidad particular de esta cepa de E.coli de colonizar la mucosa del intestino. \u201cEsto muestra que la RNRs, y en particular la prote\u00edna NrdR, regula la virulencia de la enfermedad de Crohn asociada a E. coli mediante la regulaci\u00f3n del movimiento y la propagaci\u00f3n de la bacteria\u201d, explica Eduard Torrents.<\/p>\n

Es esencial acceder a nuevos y m\u00e1s efectivos antibi\u00f3ticos ya que la resistencia antimicrobiana (AMR) es uno de los mayores riesgos sociales que amenazan a la salud humana hoy en d\u00eda. El incremento de la resistencia antibacteriana y la falta de nuevos antibi\u00f3ticos en desarrollo significa que es crucial identificar nuevas alternativas para tratar las infecciones bacterianas.<\/p>\n

Gracias a los nuevos descubrimientos, el desarrollo de f\u00e1rmacos dirigidos a la ribonucle\u00f3tido reductasa, en particular a las prote\u00ednas NrdD y NrdR, puede ser una nueva estrategia prometedora para controlar infecciones bacterianas, y particularmente para controlar la colonizaci\u00f3n del intestino por Escherichia coli.<\/p>\n

—<\/p>\n

Art\u00edculo de referencia:<\/strong><\/em> Nicolas Dreux, Maria del Mar Cendra, S\u00e9bastien Massier, Arlette Darfeuille-Michaud, Nicolas Barnich & Eduard Torrents (2015). \u201cRibonucleotide reductase NrdR as a novel regulator for motility and chemotaxis during adherent-invasive Escherichia coli infection.\u201d<\/a> Infect. Immun.<\/em>, accepted manuscript posted online 20 January 2015, doi:10.1128\/IAI.02772-14<\/p>\n","protected":false},"excerpt":{"rendered":"

\"torrentsjan\"Un grupo del Instituto de Bioingenier\u00eda de Catalunya (IBEC) ha identificado un factor importante en las infecciones de E. coli, abriendo una nueva v\u00eda hacia el desarrollo de f\u00e1rmacos dirigidos contra esta enfermedad potencialmente mortal.<\/h3>\n

La mayor\u00eda de cepas bacterianas de E. coli se encuentran de manera natural en el intestino humano y no representan ning\u00fan da\u00f1o para la salud, a excepci\u00f3n de un serotipo particular que siempre aparece en las noticias, el O157:H7, que puede causar intoxicaci\u00f3n alimentaria y la muerte en algunos pacientes.<\/p>\n","protected":false},"author":4,"featured_media":11798,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[97],"tags":[],"post_formats":[],"class_list":["post-12175","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias-de-investigacion"],"yoast_head":"\nSe identifica un actor clave en las infecciones de E. coli - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/es\/se-identifica-un-actor-clave-en-las-infecciones-de-e-coli\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Se identifica un actor clave en las infecciones de E. coli - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Un grupo del Instituto de Bioingenier\u00eda de Catalunya (IBEC) ha identificado un factor importante en las infecciones de E. coli, abriendo una nueva v\u00eda hacia el desarrollo de f\u00e1rmacos dirigidos contra esta enfermedad potencialmente mortal. La mayor\u00eda de cepas bacterianas de E. coli se encuentran de manera natural en el intestino humano y no representan ning\u00fan da\u00f1o para la salud, a excepci\u00f3n de un serotipo particular que siempre aparece en las noticias, el O157:H7, que puede causar intoxicaci\u00f3n alimentaria y la muerte en algunos pacientes.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ibecbarcelona.eu\/es\/se-identifica-un-actor-clave-en-las-infecciones-de-e-coli\/\" \/>\n<meta property=\"og:site_name\" content=\"Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"article:published_time\" content=\"2015-01-21T16:15:15+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2015-02-03T16:25:13+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2015\/01\/torrentsjan1.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"425\" \/>\n\t<meta property=\"og:image:height\" content=\"210\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"\u00c0ngels L\u00f3pez\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"\u00c0ngels L\u00f3pez\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/se-identifica-un-actor-clave-en-las-infecciones-de-e-coli\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/se-identifica-un-actor-clave-en-las-infecciones-de-e-coli\\\/\"},\"author\":{\"name\":\"\u00c0ngels L\u00f3pez\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/person\\\/c212c6b589546130be67986b9290e2b8\"},\"headline\":\"Se identifica un actor clave en las infecciones de E. coli\",\"datePublished\":\"2015-01-21T16:15:15+00:00\",\"dateModified\":\"2015-02-03T16:25:13+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/se-identifica-un-actor-clave-en-las-infecciones-de-e-coli\\\/\"},\"wordCount\":406,\"publisher\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/se-identifica-un-actor-clave-en-las-infecciones-de-e-coli\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2015\\\/01\\\/torrentsjan1.jpg\",\"articleSection\":[\"Noticias de investigaci\u00f3n\"],\"inLanguage\":\"es\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/se-identifica-un-actor-clave-en-las-infecciones-de-e-coli\\\/\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/se-identifica-un-actor-clave-en-las-infecciones-de-e-coli\\\/\",\"name\":\"Se identifica un actor clave en las infecciones de E. coli - 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