{"id":123017,"date":"2025-01-20T14:38:52","date_gmt":"2025-01-20T13:38:52","guid":{"rendered":"https:\/\/ibecbarcelona.eu\/?p=123017"},"modified":"2025-01-20T16:40:04","modified_gmt":"2025-01-20T15:40:04","slug":"printing-proteins-to-recreate-the-gut-in-the-lab","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/es\/impresion-de-proteinas-para-recrear-el-intestino-en-el-laboratorio","title":{"rendered":"Impresi\u00f3n de prote\u00ednas para recrear el intestino en el laboratorio"},"content":{"rendered":"\n<p><strong>Un estudio liderado por el IBEC describe el desarrollo de un m\u00e9todo innovador para controlar la formaci\u00f3n de estructuras similares a las criptas y vellosidades del intestino mediante una t\u00e9cnica de impresi\u00f3n de prote\u00ednas por contacto. Este modelo permitir\u00e1 estudiar en detalle procesos clave como la regeneraci\u00f3n celular o las alteraciones vinculadas a enfermedades como el c\u00e1ncer y los trastornos inflamatorios cr\u00f3nicos.<\/strong><a id=\"_msocom_1\"><\/a><\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" data-src=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/01\/EMartinezJComelles_horizontal_low-1024x683.jpg\" alt=\"\" class=\"wp-image-123011 lazyload\" data-srcset=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/01\/EMartinezJComelles_horizontal_low-1024x683.jpg 1024w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/01\/EMartinezJComelles_horizontal_low-300x200.jpg 300w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/01\/EMartinezJComelles_horizontal_low-768x512.jpg 768w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/01\/EMartinezJComelles_horizontal_low-600x400.jpg 600w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/01\/EMartinezJComelles_horizontal_low.jpg 1200w\" data-sizes=\"(max-width: 1024px) 100vw, 1024px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 1024px; --smush-placeholder-aspect-ratio: 1024\/683;\" \/><figcaption class=\"wp-element-caption\">Elena Mart\u00ednez (izquierda) y Jordi Comelles (derecha) en los laboratorios del IBEC.<\/figcaption><\/figure>\n\n\n\n<p>El m\u00e9todo desarrollado por el <a href=\"https:\/\/ibecbarcelona.eu\/es\/biomsyscelleng\">grupo de Sistemas Biomim\u00e9ticos para Ingenier\u00eda Celular<\/a> del IBEC se basa en la impresi\u00f3n de patrones definidos de prote\u00ednas clave, como Wnt3a y EphrinB1, sobre una membrana basal. Estas prote\u00ednas son esenciales para la organizaci\u00f3n y diferenciaci\u00f3n del tejido epitelial intestinal. Gracias a esta t\u00e9cnica, los investigadores lograron controlar c\u00f3mo y d\u00f3nde se forman estructuras como las criptas y vellosidades intestinales. Adem\u00e1s, el sistema permite estudiar el papel de cada una de estas prote\u00ednas de manera individual y controlada.<a id=\"_msocom_1\"><\/a><\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p>Lo que conseguimos con nuestro m\u00e9todo, basado en la de impresi\u00f3n de prote\u00ednas por contacto, es controlar c\u00f3mo y d\u00f3nde se forman estas estructuras intestinales. <\/p>\n\n\n\n<p>Jordi Comelles<\/p>\n<\/blockquote>\n\n\n\n<p>\u201cLas c\u00e9lulas con las que trabajamos se autoorganizan en compartimentos diferenciados que replican con precisi\u00f3n las estructuras intestinales. Lo que conseguimos con nuestro m\u00e9todo, basado en la de impresi\u00f3n de prote\u00ednas por contacto, es controlar c\u00f3mo y d\u00f3nde se forman estas estructuras. Lo hacemos disponiendo estas prote\u00ednas en patrones espec\u00edficos, como c\u00edrculos o agujeros\u201d, explica Jordi Comelles, investigador s\u00e9nior del IBEC, profesor asociado en la Universidad de Barcelona (UB) y coautor del estudio.<\/p>\n\n\n\n<p>Esta innovadora metodolog\u00eda permite, adem\u00e1s, analizar individualmente los factores implicados en la organizaci\u00f3n y funcionamiento del intestino, desvelando su papel en procesos clave como la proliferaci\u00f3n y diferenciaci\u00f3n celular. \u201cHemos observado, por ejemplo, que el Wnt3a ex\u00f3geno puede reducir la producci\u00f3n del mismo factor a nivel end\u00f3geno, lo que abre nuevas posibilidades para manipular estas v\u00edas de se\u00f1alizaci\u00f3n\u201d, a\u00f1ade Comelles.<a id=\"_msocom_1\"><\/a><\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p>Este modelo nos permitir\u00e1 estudiar en detalle procesos clave como la regeneraci\u00f3n celular o las alteraciones vinculadas a enfermedades como el c\u00e1ncer y los trastornos inflamatorios cr\u00f3nicos.<\/p>\n\n\n\n<p>Elena Mart\u00ednez<\/p>\n<\/blockquote>\n\n\n\n<p>Este enfoque permite controlar c\u00f3mo las c\u00e9lulas intestinales se agrupan, dependiendo del tama\u00f1o y la disposici\u00f3n de los patrones de Wnt3a. \u201cNuestro objetivo era crear un sistema que refleje de forma m\u00e1s fiel las condiciones del tejido intestinal humano. Este modelo nos permitir\u00e1 estudiar en detalle procesos clave como la regeneraci\u00f3n celular o las alteraciones vinculadas a enfermedades como el c\u00e1ncer y los trastornos inflamatorios cr\u00f3nicos\u201d, se\u00f1ala Elena Mart\u00ednez Fraiz, investigadora principal del IBEC, profesora agregada de la UB y l\u00edder del estudio.<\/p>\n\n\n\n<p>Por otro lado, el equipo utiliz\u00f3 modelos computacionales para simular las interacciones entre las v\u00edas de se\u00f1alizaci\u00f3n, obteniendo una visi\u00f3n m\u00e1s detallada de los procesos implicados en la organizaci\u00f3n celular. Este avance no solo mejora nuestra comprensi\u00f3n de la biolog\u00eda intestinal, sino que tambi\u00e9n ofrece nuevas oportunidades para probar medicamentos, estudiar enfermedades en un entorno controlado y desarrollar tratamientos m\u00e1s efectivos.<\/p>\n\n\n\n<p>Este trabajo forma parte de la tesis doctoral desarrollada por Enara Larra\u00f1aga en el grupo de Mart\u00ednez en el IBEC. La investigaci\u00f3n ha contado adem\u00e1s con la colaboraci\u00f3n del <a href=\"https:\/\/ibecbarcelona.eu\/es\/industry-and-hospitals\/bioengineering-in-reproductive-health\/\">grupo de Bioingenier\u00eda en Salud Reproductiva<\/a> del IBEC, liderado por Samuel Ojosnegros; el Centro de Investigaci\u00f3n Biom\u00e9dica en Red \u2013 Bioingenier\u00eda, Biomateriales y nanomedicina (CIBER-BBN), el Laboratorio Europeo de Biolog\u00eda Molecular (EMBL) de Barcelona y el Instituto de Investigaci\u00f3n Biom\u00e9dica (IRB Barcelona).<a id=\"_msocom_1\"><\/a><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p><strong>Art\u00edculo referenciado:<\/strong><\/p>\n\n\n\n<p>Enara Larra\u00f1aga, Miquel Marin-Riera, Aina Abad-L\u00e1zaro, David Bartolom\u00e9-Catal\u00e0, Aitor Otero, Vanesa Fern\u00e1ndez-Majada, Eduard Batlle, James Sharpe, Samuel Ojosnegros, Jordi Comelles &amp; Elena Mart\u00ednez. <strong>Long-range organization of intestinal 2D-crypts using exogenous Wnt3a micropatterning<\/strong>. <em>Nature Communications<\/em> (2025). DOI: <a href=\"https:\/\/doi.org\/10.1038\/s41467-024-55651-7\">https:\/\/doi.org\/10.1038\/s41467-024-55651-7<\/a><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n","protected":false},"excerpt":{"rendered":"<p>An IBEC-led study describes the development of an innovative method to control the formation of crypt-like structures and villi in the intestine using a contact protein printing technique. This model will make it possible to study in detail key processes such as cell regeneration or changes associated with diseases such as cancer and chronic inflammatory disorders.<\/p>\n","protected":false},"author":37,"featured_media":123013,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[97],"tags":[1784,1827,825,1072],"post_formats":[],"class_list":["post-123017","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias-de-investigacion","tag-bioengineering-in-reproductive-health-es","tag-biomimetic-systems-for-cell-engineering-es","tag-elena-martinez-es","tag-samuel-ojosnegros-es"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Impresi\u00f3n de prote\u00ednas para recrear el intestino en el laboratorio - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/es\/impresion-de-proteinas-para-recrear-el-intestino-en-el-laboratorio\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Impresi\u00f3n de prote\u00ednas para recrear el intestino en el laboratorio - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"An IBEC-led study describes the development of an innovative method to control the formation of crypt-like structures and villi in the intestine using a contact protein printing technique. 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