{"id":123189,"date":"2025-01-23T16:13:16","date_gmt":"2025-01-23T15:13:16","guid":{"rendered":"https:\/\/ibecbarcelona.eu\/?p=123189"},"modified":"2025-01-23T16:15:57","modified_gmt":"2025-01-23T15:15:57","slug":"intropy-a-new-approach-to-cancer-therapy-by-inhibiting-mechanotransduction","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/es\/intropy%3A-un-nuevo-enfoque-en-la-terapia-contra-el-cancer-mediante-la-inhibicion-de-la-mecanotransduccion","title":{"rendered":"INTROPY: Un nuevo enfoque en la terapia contra el c\u00e1ncer mediante la inhibici\u00f3n de la mecanotransducci\u00f3n"},"content":{"rendered":"\n<p><strong>El investigador principal del IBEC Pere Roca-Cusachs ha obtenido una \u201cERC Proof of Concept Grant\u201d. Se trata de una prestigiosa financiaci\u00f3n que concede el Consejo Europeo de Investigaci\u00f3n para explorar el potencial comercial y social de proyectos de investigaci\u00f3n llevados a cabo en instituciones europeas. El proyecto de Roca-Cusachs, INTROPY, se enfoca en la inhibici\u00f3n de la mecanotransducci\u00f3n como potencial terapia contra el c\u00e1ncer o la fibrosis.<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" data-src=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/01\/PRoca_IBEC_low-1024x683.png\" alt=\"\" class=\"wp-image-123184 lazyload\" data-srcset=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/01\/PRoca_IBEC_low-1024x683.png 1024w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/01\/PRoca_IBEC_low-300x200.png 300w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/01\/PRoca_IBEC_low-768x512.png 768w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/01\/PRoca_IBEC_low-600x400.png 600w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/01\/PRoca_IBEC_low.png 1200w\" data-sizes=\"(max-width: 1024px) 100vw, 1024px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 1024px; --smush-placeholder-aspect-ratio: 1024\/683;\" \/><\/figure>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>Pere Roca-Cusachs Soulere, profesor catedr\u00e1tico de la Facultad de Medicina y Ciencias de la Salud de la Universidad de Barcelona (UB) y l\u00edder del grupo <a href=\"https:\/\/ibecbarcelona.eu\/es\/cellmolmech\">Mecanobiolog\u00eda celular y molecular<\/a> en el IBEC, ha sido galardonado con una \u201cERC Proof of Concept Grant\u201d. Se trata de una prestigiosa subvenci\u00f3n que concede el Consejo Europeo de Investigaci\u00f3n (ERC, por sus siglas en ingl\u00e9s) y tiene como objetivo explorar el potencial comercial y social de proyectos de investigaci\u00f3n que est\u00e1n o han sido financiados previamente por el ERC. Los y las solicitantes utilizan este tipo de financiaci\u00f3n para verificar la viabilidad practica de conceptos cient\u00edficos, explorar oportunidades de negocio o preparar solicitudes de patentes.<\/p>\n\n\n\n<p>El proyecto de Roca-Cusachs y la investigadora postdoctoral Mamatha Nijaguna, denominado INTROPY, se centra en la inhibici\u00f3n de la mecanotransducci\u00f3n como una nueva estrategia para la terapia oncol\u00f3gica. La mecanotransducci\u00f3n es el proceso mediante el cual las c\u00e9lulas convierten cambios mec\u00e1nicos en respuestas biol\u00f3gicas, regulando procesos como el desarrollo embrionario, la progresi\u00f3n tumoral y la curaci\u00f3n de heridas.<\/p>\n\n\n\n<p>Un cambio mec\u00e1nico com\u00fan es el endurecimiento de los tejidos, que ocurre, por ejemplo, en el c\u00e1ncer y facilita el crecimiento m\u00e1s r\u00e1pido de los tumores. En este contexto, el equipo de Roca-Cusachs ha identificado una interacci\u00f3n clave entre dos prote\u00ednas esenciales para la mecanotransducci\u00f3n y propone un enfoque terap\u00e9utico que inhibe este proceso mediante la inhibici\u00f3n de estas prote\u00ednas diana.<\/p>\n\n\n\n<p>A trav\u00e9s de diversas pruebas de cribado, los investigadores han encontrado seis mol\u00e9culas con gran potencial para actuar sobre estas prote\u00ednas. Con el proyecto INTROPY, se espera validar estos resultados y aportar pruebas de concepto de su potencial para el tratamiento del c\u00e1ncer, tanto in vitro como en modelos de rat\u00f3n.<\/p>\n\n\n\n<p>Este enfoque innovador tiene el potencial de transformar la terapia contra el c\u00e1ncer y proporcionar nuevos conocimientos sobre el papel de las se\u00f1ales mec\u00e1nicas en la progresi\u00f3n de la enfermedad.<\/p>\n\n\n\n<p>Si el proyecto tiene \u00e9xito, los investigadores esperan poder establecer una <em>spin-off<\/em> para llevar el desarrollo de estos f\u00e1rmacos a fases cl\u00ednicas. Esto podr\u00eda dar lugar al primer f\u00e1rmaco mecanoinhibidor de su clase, con aplicaciones potenciales en el tratamiento del c\u00e1ncer (enfocado en el c\u00e1ncer de mama y de p\u00e1ncreas) y otras enfermedades caracterizadas por estr\u00e9s mec\u00e1nico, como la fibrosis.<\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>El investigador principal del IBEC Pere Roca-Cusachs ha obtenido una \u201cERC Proof of Concept Grant\u201d. Se trata de una prestigiosa financiaci\u00f3n que concede el Consejo Europeo de Investigaci\u00f3n para explorar el potencial comercial y social de proyectos de investigaci\u00f3n llevados a cabo en instituciones europeas. El proyecto de Roca-Cusachs, INTROPY, se enfoca en la inhibici\u00f3n de la mecanotransducci\u00f3n como potencial terapia contra el c\u00e1ncer o la fibrosis.<\/p>\n","protected":false},"author":37,"featured_media":123186,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[94],"tags":[1813,2062,1413,1135,1819],"post_formats":[],"class_list":["post-123189","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias-institucionales","tag-cellular-and-molecular-mechanobiology-es","tag-erc-es","tag-erc-grant-es","tag-pere-roca-cusachs-es","tag-premio"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>INTROPY: Un nuevo enfoque en la terapia contra el c\u00e1ncer mediante la inhibici\u00f3n de la mecanotransducci\u00f3n - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/es\/intropy:-un-nuevo-enfoque-en-la-terapia-contra-el-cancer-mediante-la-inhibicion-de-la-mecanotransduccion\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"INTROPY: Un nuevo enfoque en la terapia contra el c\u00e1ncer mediante la inhibici\u00f3n de la mecanotransducci\u00f3n - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"El investigador principal del IBEC Pere Roca-Cusachs ha obtenido una \u201cERC Proof of Concept Grant\u201d. Se trata de una prestigiosa financiaci\u00f3n que concede el Consejo Europeo de Investigaci\u00f3n para explorar el potencial comercial y social de proyectos de investigaci\u00f3n llevados a cabo en instituciones europeas. 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