{"id":124335,"date":"2025-02-27T12:26:44","date_gmt":"2025-02-27T11:26:44","guid":{"rendered":"https:\/\/ibecbarcelona.eu\/?p=124335"},"modified":"2025-02-24T10:03:20","modified_gmt":"2025-02-24T09:03:20","slug":"novel-nanomotors-improve-bladder-cancer-immunotherapy","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/es\/un-nuevo-tipo-de-nanomotores-mejora-la-inmunoterapia-contra-el-cancer-de-vejiga","title":{"rendered":"Un nuevo tipo de nanomotores mejora la inmunoterapia contra el c\u00e1ncer de vejiga"},"content":{"rendered":"\n<p><strong>Un estudio liderado por el Instituto de Bioingenier\u00eda de Catalu\u00f1a (IBEC) y la Universidad de Ciencia y Tecnolog\u00eda de Pohang (POSTECH) en Corea del Sur describe el desarrollo de nanomotores propulsados por urea que mejoran la inmunoterapia contra el c\u00e1ncer de vejiga.<\/strong> <strong>Los nanomotores activan el sistema inmunol\u00f3gico de manera m\u00e1s eficiente y superan la eficacia de los tratamientos utilizados actualmente, ofreciendo nuevas oportunidades en oncolog\u00eda.<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" data-src=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/02\/JL11074_low-1024x683.jpg\" alt=\"\" class=\"wp-image-124325 lazyload\" data-srcset=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/02\/JL11074_low-1024x683.jpg 1024w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/02\/JL11074_low-300x200.jpg 300w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/02\/JL11074_low-768x512.jpg 768w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/02\/JL11074_low-600x400.jpg 600w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/02\/JL11074_low.jpg 1200w\" data-sizes=\"(max-width: 1024px) 100vw, 1024px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 1024px; --smush-placeholder-aspect-ratio: 1024\/683;\" \/><figcaption class=\"wp-element-caption\">Samuel S\u00e1nchez en los laboratorios del IBEC.<\/figcaption><\/figure>\n\n\n\n<p>Un equipo de investigaci\u00f3n liderado por el Instituto de Bioingenier\u00eda de Catalu\u00f1a (IBEC) y la Universidad de Ciencia y Tecnolog\u00eda de Pohang (POSTECH) en Corea del Sur ha desarrollado una innovadora estrategia basada en nanomotores para mejorar la inmunoterapia contra el c\u00e1ncer de vejiga. El estudio, publicado en la revista <em>Nature Communications,<\/em> ofrece una alternativa prometedora a las limitaciones de los tratamientos disponibles.<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p>Hemos demostrado que nuestro enfoque es m\u00e1s eficaz que el tratamiento convencional con BCG en ratones, lo que supone un gran avance en la inmunoterapia para este tipo de c\u00e1ncer.<\/p>\n\n\n\n<p>Samuel S\u00e1nchez<\/p>\n<\/blockquote>\n\n\n\n<p>Hoy en d\u00eda el tratamiento convencional para el c\u00e1ncer de vejiga no invasivo es la inmunoterapia con BCG (Bacillus Calmette-Gu\u00e9rin), una bacteria atenuada que se introduce en la vejiga para estimular la respuesta inmune contra las c\u00e9lulas tumorales. Sin embargo, este tratamiento presenta limitaciones importantes, como la necesidad de m\u00faltiples administraciones, efectos secundarios graves y una eficacia reducida en ciertos pacientes. Frente a estos inconvenientes, la nueva terapia basada en nanomotores ofrece una alternativa m\u00e1s eficaz, activando de forma m\u00e1s eficiente el sistema inmunol\u00f3gico y reduciendo significativamente el crecimiento tumoral en modelos precl\u00ednicos en rat\u00f3n.<\/p>\n\n\n\n<p>Estos nanomotores son nanopart\u00edculas autopropulsadas que utilizan la enzima ureasa para reaccionar con la urea presente en la orina. Esta capacidad de movimiento les permite distribuirse de manera m\u00e1s eficiente en la vejiga, alcanzando las c\u00e9lulas tumorales de forma m\u00e1s precisa y prolongando el tiempo de retenci\u00f3n del f\u00e1rmaco en el tejido afectado.<\/p>\n\n\n\n<p>En su superficie, los nanomotores transportan un agonista de STING, una mol\u00e9cula clave en la activaci\u00f3n del sistema inmunol\u00f3gico. <strong>\u201cHemos demostrado que nuestro enfoque es m\u00e1s eficaz que el tratamiento convencional con BCG en ratones, lo que supone un gran avance en la inmunoterapia para este tipo de c\u00e1ncer\u201d<\/strong>, explica Samuel S\u00e1nchez, profesor de investigaci\u00f3n ICREA en el IBEC y col\u00edder del estudio.<\/p>\n\n\n\n<p>Para potenciar a\u00fan m\u00e1s la respuesta inmune, los investigadores combinaron los nanomotores con un inhibidor de PD-1, un tratamiento que bloquea un mecanismo de evasi\u00f3n utilizado por las c\u00e9lulas tumorales. <strong>\u201cLa combinaci\u00f3n de nuestros nanomotores con el tratamiento anti-PD-1 ha mostrado una sinergia extraordinaria, lo que podr\u00eda traducirse en terapias combinadas m\u00e1s eficaces y con menos efectos secundarios\u201d<\/strong>, a\u00f1ade S\u00e1nchez.<\/p>\n\n\n\n<p>El estudio representa un importante avance en la b\u00fasqueda de nuevas estrategias terap\u00e9uticas para el c\u00e1ncer de vejiga, una enfermedad con alta tasa de recurrencia que requiere tratamientos agresivos y prolongados.<\/p>\n\n\n\n<p>Este trabajo ha contado con la participaci\u00f3n de PHI BIOMED Co., la Universidad Nacional de Se\u00fal, el Hospital Universitario Nacional de Se\u00fal, el CIC biomaGUNE del Pa\u00eds Vasco y el Instituto Avanzado de Ciencia y Tecnolog\u00eda de Corea (KAIST).<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"904\" height=\"1024\" data-src=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/02\/41467_2024_54293_Fig1_HTML_low-904x1024.jpg\" alt=\"\" class=\"wp-image-124329 lazyload\" data-srcset=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/02\/41467_2024_54293_Fig1_HTML_low-904x1024.jpg 904w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/02\/41467_2024_54293_Fig1_HTML_low-265x300.jpg 265w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/02\/41467_2024_54293_Fig1_HTML_low-768x870.jpg 768w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/02\/41467_2024_54293_Fig1_HTML_low.jpg 1200w\" data-sizes=\"(max-width: 904px) 100vw, 904px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 904px; --smush-placeholder-aspect-ratio: 904\/1024;\" \/><figcaption class=\"wp-element-caption\"><strong>a<\/strong>\u00a0Administraci\u00f3n intravesical de nanomotores propulsados por ureasa para la inmunoterapia del c\u00e1ncer de vejiga y (<strong>b<\/strong>) procedimiento de preparaci\u00f3n de nanomotores propulsados por ureasa que contienen el agonista de STING (STING@nanomotor, tama\u00f1o = aprox. 600 nm) mediante la interacci\u00f3n electrost\u00e1tica de quitosano y heparina. <strong>a<\/strong> creado en BioRender. Choi, H. (2024) <a href=\"https:\/\/BioRender.com\/u13b061\">https:\/\/BioRender.com\/u13b061<\/a>.<\/figcaption><\/figure>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p><strong>Art\u00edculo referenciado: <\/strong><\/p>\n\n\n\n<p>Hyunsik Choi, Seung-hwan Jeong, Cristina Sim\u00f3, Anna Bakenecker, Jordi Liop, Hye Sun Lee, Tae Yeon Kim, Cheol Kwak, Gou Young Koh, Samuel S\u00e1nchez &amp; Sei Kwang Hahn. <strong>Urease-powered nanomotor containing STING agonist for bladder cancer immunotherapy<\/strong>. <em>Nature Communications<\/em> (2024). DOI: <a href=\"https:\/\/doi.org\/10.1038\/s41467-024-54293-z\">10.1038\/s41467-024-54293-z<\/a><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n","protected":false},"excerpt":{"rendered":"<p>A study led by the Institute for Bioengineering of Catalonia (IBEC) and Pohang University of Science and Technology (POSTECH) in South Korea describes the development of urea-powered nanomotors that improve immunotherapy for bladder cancer. The nanomotors activate the immune system more efficiently and exceed the efficacy of currently used treatments, opening up new possibilities in oncology.<\/p>\n","protected":false},"author":37,"featured_media":124327,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[97],"tags":[1775,1928,2010,1139,1820],"post_formats":[],"class_list":["post-124335","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias-de-investigacion","tag-cancer-es","tag-cancer-de-vejiga","tag-nanobots-es","tag-samuel-sanchez-es","tag-smart-nano-bio-devices-es"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Un nuevo tipo de nanomotores mejora la inmunoterapia contra el c\u00e1ncer de vejiga - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/es\/un-nuevo-tipo-de-nanomotores-mejora-la-inmunoterapia-contra-el-cancer-de-vejiga\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Un nuevo tipo de nanomotores mejora la inmunoterapia contra el c\u00e1ncer de vejiga - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"A study led by the Institute for Bioengineering of Catalonia (IBEC) and Pohang University of Science and Technology (POSTECH) in South Korea describes the development of urea-powered nanomotors that improve immunotherapy for bladder cancer. 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