{"id":128283,"date":"2025-09-04T14:39:36","date_gmt":"2025-09-04T12:39:36","guid":{"rendered":"https:\/\/ibecbarcelona.eu\/chemtubio-a-new-erc-project-at-ibec-to-study-enzymes-with-therapeutic-potential\/"},"modified":"2025-09-04T14:59:17","modified_gmt":"2025-09-04T12:59:17","slug":"chemtubio-a-new-erc-project-at-ibec-to-study-enzymes-with-therapeutic-potential","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/es\/chemtubio-un-nuevo-proyecto-erc-en-el-ibec-para-estudiar-enzimas-con-potencial-terapeutico","title":{"rendered":"CHEMTUBIO, un nuevo proyecto ERC en el IBEC para estudiar enzimas con potencial terap\u00e9utico"},"content":{"rendered":"\n

Carlos Moreno Yruela, actualmente investigador en la Escuela Polit\u00e9cnica Federal de Lausana (Suiza), ha sido seleccionado en la convocatoria \u201cStarting Grant\u201d del Consejo Europeo de Investigaci\u00f3n (ERC) para desarrollar su proyecto \u00abCHEMTUBIO\u00bb en el Instituto de Bioingenier\u00eda de Catalu\u00f1a (IBEC). Este proyecto tiene como objetivo el estudio qu\u00edmico de las enzimas borradoras de modificaciones de microt\u00fabulos. Se trata de un tipo de enzimas fundamentales para el funcionamiento de nuestras c\u00e9lulas que han mostrado un prometedor potencial como dianas terap\u00e9uticas para el tratamiento del c\u00e1ncer, as\u00ed como de enfermedades card\u00edacas y neuronales.<\/strong><\/p>\n\n\n\n

\"\"
Carlos Moreno Yruela<\/figcaption><\/figure>\n\n\n\n

Existen un tipo de enzimas poco conocidas pero fundamentales para el funcionamiento de nuestras c\u00e9lulas: las llamadas \u201cborradoras\u201d de modificaciones qu\u00edmicas en prote\u00ednas. Estas enzimas regulan procesos esenciales de la vida celular y algunas ya sirven de diana terap\u00e9utica de f\u00e1rmacos utilizados contra el c\u00e1ncer. Sin embargo, todav\u00eda existen muchas otras de las que apenas se conoce informaci\u00f3n, en parte porque resultan muy dif\u00edciles de analizar con las t\u00e9cnicas convencionales.<\/p>\n\n\n\n

El proyecto CHEMTUBIO, que liderar\u00e1Carlos Moreno Yruela en el Instituto de Bioingenier\u00eda de Catalu\u00f1a (IBEC), busca superar esta limitaci\u00f3n mediante una estrategia innovadora que permite observar la actividad de estas enzimas directamente sobre prote\u00ednas completas, y no solo en fragmentos artificiales como se hace habitualmente. Esta aproximaci\u00f3n no solo facilitar\u00e1 el desarrollo de nuevos medicamentos, sino que tambi\u00e9n permitir\u00e1 cartografiar la acci\u00f3n de las enzimas dentro de las c\u00e9lulas vivas.<\/p>\n\n\n\n

En particular, el proyecto se centra en las enzimas que act\u00faan sobre la prote\u00edna tubulina, que forma los microt\u00fabulos, un componente clave del esqueleto celular. Estas enzimas act\u00faan generando patrones qu\u00edmicos y se sabe que inhibir su acci\u00f3n podr\u00eda resultar \u00fatil para tratar enfermedades card\u00edacas y neuronales. Sin embargo, los mecanismos de acci\u00f3n de estas enzimas son todav\u00eda desconocidos debido a la falta de m\u00e9todos adecuados para estudiarlos. En este contexto, el proyecto CHEMTUBIO pretende crear sondas y sensores qu\u00edmicos para descifrar estos procesos y abrir nuevas v\u00edas terap\u00e9uticas.<\/p>\n\n\n\n

Adem\u00e1s, Moreno y su equipo desarrollar\u00e1n t\u00e9cnicas pioneras para estudiar modificaciones que ocurren en el interior de los microt\u00fabulos. Comprender estos mecanismos podr\u00eda impulsar avances en el tratamiento de enfermedades neuromusculares y en la lucha contra el c\u00e1ncer.<\/p>\n\n\n\n

La \u201cStarting Grant\u201d del ERC (Consejo Europeo de Investigaci\u00f3n) es una prestigiosa subvenci\u00f3n destinada a investigadores j\u00f3venes y talentosos en las primeras etapas de sus carreras cient\u00edficas independientes. Est\u00e1 dise\u00f1ada para financiar proyectos de investigaci\u00f3n innovadores y ambiciosos que aborden preguntas cient\u00edficas de vanguardia. Los beneficiarios reciben fondos significativos para establecer sus propios grupos de investigaci\u00f3n y llevar a cabo investigaciones de alto nivel durante un per\u00edodo de hasta cinco a\u00f1os. Esta subvenci\u00f3n se otorga en funci\u00f3n de la excelencia cient\u00edfica y la originalidad del proyecto propuesto y es altamente competitiva en el \u00e1mbito europeo. <\/p>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

Carlos Moreno Yruela, who is currently a researcher at the Swiss Federal Institute of Technology in Lausanne, Switzerland, was selected in the ERC Starting Grants call to develop the CHEMTUBIO project at the Institute for Bioengineering of Catalonia (IBEC). The project will study the chemistry of enzymes that erase microtubule modifications. These enzymes are essential for the functioning of our cells and have shown great promise as potential therapeutic targets for treating cancer, heart disease and neurological disorders.<\/p>\n","protected":false},"author":37,"featured_media":128280,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[94],"tags":[2062,1413],"post_formats":[],"class_list":["post-128283","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias-institucionales","tag-erc-es","tag-erc-grant-es"],"yoast_head":"\nCHEMTUBIO, un nuevo proyecto ERC en el IBEC para estudiar enzimas con potencial terap\u00e9utico - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/es\/chemtubio-un-nuevo-proyecto-erc-en-el-ibec-para-estudiar-enzimas-con-potencial-terapeutico\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"CHEMTUBIO, un nuevo proyecto ERC en el IBEC para estudiar enzimas con potencial terap\u00e9utico - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Carlos Moreno Yruela, who is currently a researcher at the Swiss Federal Institute of Technology in Lausanne, Switzerland, was selected in the ERC Starting Grants call to develop the CHEMTUBIO project at the Institute for Bioengineering of Catalonia (IBEC). 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