{"id":128478,"date":"2025-09-25T14:41:47","date_gmt":"2025-09-25T12:41:47","guid":{"rendered":"https:\/\/ibecbarcelona.eu\/high-fat-diets-alter-genes-differently-in-males-and-females\/"},"modified":"2025-09-25T15:38:56","modified_gmt":"2025-09-25T13:38:56","slug":"high-fat-diets-alter-genes-differently-in-males-and-females","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/es\/las-dietas-ricas-en-grasa-alteran-de-forma-distinta-los-genes-en-machos-y-hembras","title":{"rendered":"Las dietas ricas en grasa alteran de forma distinta los genes en machos y hembras"},"content":{"rendered":"\n<p><strong><strong>Un estudio liderado por el \u00e1rea de Diabetes y Enfermedades Metab\u00f3licas Asociadas del CIBER (CIBERDEM) en colaboraci\u00f3n con el instituto de Bioingenier\u00eda de Catalu\u00f1a (IBEC) ha demostrado que las dietas ricas en grasas modifican, de forma distinta en funci\u00f3n del sexo, la expresi\u00f3n de genes en tejidos clave para el control metab\u00f3lico. Estos resultados aportan una nueva perspectiva sobre c\u00f3mo la obesidad impacta de forma distinta en funci\u00f3n del sexo.<\/strong><\/strong><\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" data-src=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/09\/joan-marc-1024x683.jpg\" alt=\"\" class=\"wp-image-128472 lazyload\" data-srcset=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/09\/joan-marc-1024x683.jpg 1024w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/09\/joan-marc-300x200.jpg 300w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/09\/joan-marc-768x512.jpg 768w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/09\/joan-marc-1536x1024.jpg 1536w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/09\/joan-marc-2048x1365.jpg 2048w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/09\/joan-marc-1200x800.jpg 1200w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2025\/09\/joan-marc-600x400.jpg 600w\" data-sizes=\"(max-width: 1024px) 100vw, 1024px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 1024px; --smush-placeholder-aspect-ratio: 1024\/683;\" \/><figcaption class=\"wp-element-caption\">Equipo del CIBERDEM.<\/figcaption><\/figure>\n\n\n\n<p>Varios grupos del \u00e1rea de Diabetes y Enfermedades Metab\u00f3licas Asociadas del CIBER (CIBERDEM) han demostrado, en modelos murinos, que las dietas ricas en grasas modifican, de manera profunda y de forma distinta en funci\u00f3n del sexo, la expresi\u00f3n de genes en tejidos clave para el control metab\u00f3lico, siendo los genes que normalmente marcan diferencias entre sexos los m\u00e1s sensibles a los efectos de la obesidad.<\/p>\n\n\n\n<p>El trabajo, publicado recientemente en la revista American Journal of Physiology \u2013 Cell Physiology, ha contado con la participaci\u00f3n de personal investigador del Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) y del Instituto de Bioingenier\u00eda de Catalu\u00f1a (IBEC).<\/p>\n\n\n\n<p>Observaron que, en ratones sometidos a dietas ricas en grasas, los machos presentaron un deterioro metab\u00f3lico m\u00e1s severo, a pesar de que ambos sexos desarrollaron una cantidad similar de grasa corporal. Al analizar los cambios en la expresi\u00f3n g\u00e9nica del h\u00edgado y el tejido adiposo, comprobaron que la obesidad alteraba de forma muy distinta la expresi\u00f3n de los genes seg\u00fan el sexo<em>. \u201cEl hallazgo m\u00e1s sorprendente fue descubrir que los <a>genes que marcan diferencias entre sexos en condiciones normales, llamados genes \u2018sexualmente dim\u00f3rficos\u2019, son precisamente los m\u00e1s sensibles a las dietas obesog\u00e9nicas<\/a>\u201d<\/em> indica Joan-Marc Servitja, investigador CIBERDEM y col\u00edder del estudio. Como consecuencia, se produce una p\u00e9rdida de las diferencias naturales en la expresi\u00f3n g\u00e9nica entre sexos, lo que indica que la obesidad puede borrar patrones espec\u00edficos de cada sexo fundamentales para el equilibrio metab\u00f3lico.<\/p>\n\n\n\n<p>Estos resultados aportan <em>\u201cuna nueva perspectiva sobre c\u00f3mo la obesidad impacta de forma distinta en funci\u00f3n del sexo y ponen de relieve que las diferencias de expresi\u00f3n g\u00e9nica entre sexos desempe\u00f1an un papel clave en la salud metab\u00f3lica\u201d,<\/em> concluye Vicent Ribas investigador CIBERDEM y col\u00edder del estudio. El estudio subraya la importancia de analizar ambos sexos en la investigaci\u00f3n sobre enfermedades metab\u00f3licas, ya que este enfoque puede ser decisivo para dise\u00f1ar estrategias de prevenci\u00f3n y tratamiento m\u00e1s eficaces.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p><strong><strong><strong><strong>Art\u00edculo de referencia:<\/strong><\/strong><\/strong><\/strong><\/p>\n\n\n\n<p>Vicent Ribas, Samantha Mor\u00f3n-Ros, Helena Mari, Albert Gracia-Batllori, Laura Brugnara, Alba Herrero-Gomez, Elena Eyre, Marc Claret, Irene Marco-Rius, Anna Novials, Joan-Marc Servitja. <strong>Diet-Induced Obesity Disrupts Sexually Dimorphic Gene Expression in Mice<\/strong>. <em>Am J Physiol Cell Physiol<\/em>. (2025). DOI: <a href=\"https:\/\/journals.physiology.org\/doi\/full\/10.1152\/ajpcell.00098.2025\">10.1152\/ajpcell.00098.2025<\/a>.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Un estudio liderado por el \u00e1rea de Diabetes y Enfermedades Metab\u00f3licas Asociadas del CIBER (CIBERDEM) en colaboraci\u00f3n con el instituto de Bioingenier\u00eda de Catalu\u00f1a (IBEC) ha demostrado que las dietas ricas en grasas modifican, de forma distinta en funci\u00f3n del sexo, la expresi\u00f3n de genes en tejidos clave para el control metab\u00f3lico. Estos resultados aportan una nueva perspectiva sobre c\u00f3mo la obesidad impacta de forma distinta en funci\u00f3n del sexo.<\/p>\n","protected":false},"author":37,"featured_media":128474,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[97],"tags":[1121,1737],"post_formats":[],"class_list":["post-128478","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias-de-investigacion","tag-irene-marco-rius-es","tag-molecular-imaging-for-precision-medicine-es"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Las dietas ricas en grasa alteran de forma distinta los genes en machos y hembras - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/es\/las-dietas-ricas-en-grasa-alteran-de-forma-distinta-los-genes-en-machos-y-hembras\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Las dietas ricas en grasa alteran de forma distinta los genes en machos y hembras - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Un estudio liderado por el \u00e1rea de Diabetes y Enfermedades Metab\u00f3licas Asociadas del CIBER (CIBERDEM) en colaboraci\u00f3n con el instituto de Bioingenier\u00eda de Catalu\u00f1a (IBEC) ha demostrado que las dietas ricas en grasas modifican, de forma distinta en funci\u00f3n del sexo, la expresi\u00f3n de genes en tejidos clave para el control metab\u00f3lico. 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