{"id":134610,"date":"2026-07-02T09:00:00","date_gmt":"2026-07-02T07:00:00","guid":{"rendered":"https:\/\/ibecbarcelona.eu\/?p=134610"},"modified":"2026-07-01T15:14:19","modified_gmt":"2026-07-01T13:14:19","slug":"nou-estudi-revela-com-el-comportament-de-les-proteines-impulsa-especialitzacio-de-la-barrera-hematoencefalica","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/es\/nou-estudi-revela-com-el-comportament-de-les-proteines-impulsa-especialitzacio-de-la-barrera-hematoencefalica\/","title":{"rendered":"Nou estudi revela com el comportament de les prote\u00efnes impulsa l’especialitzaci\u00f3 de la barrera hematoencef\u00e0lica"},"content":{"rendered":"\n

Una investigaci\u00f3 liderada per l’Institut de Bioenginyeria de Catalunya (IBEC) revela que la barrera hematoencef\u00e0lica es defineix no nom\u00e9s per les prote\u00efnes que expressa, sin\u00f3 per com les utilitza, a trav\u00e9s d’una propietat din\u00e0mica coneguda com a taxa de recanvi endoc\u00edtic (ETOR).<\/strong> Aquest descobriment mostra que les c\u00e8l\u00b7lules endotelials cerebrals tenen un comportament molecular \u00fanic que les distingeix d’altres vasos sanguinis i que pot alterar-se durant la inflamaci\u00f3.<\/strong> Els resultats aporten nous coneixements sobre com funciona i s’altera aquesta barrera en el context de malalties, cosa que podria ajudar a identificar noves estrat\u00e8gies terap\u00e8utiques per restaurar la salut neurovascular.<\/strong><\/p>\n\n\n\n

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Un estudi liderat per investigadors de l’Institut de Bioenginyeria de Catalunya (IBEC)<\/strong>, en col\u00b7laboraci\u00f3 amb la Plataforma de Prote\u00f2mica de l’Institut de Recerca Biom\u00e8dica (IRB Barcelona)<\/strong>, ha descobert un mecanisme clau que ajuda a definir com funciona la barrera hematoencef\u00e0lica, no nom\u00e9s en funci\u00f3 de quines prote\u00efnes hi s\u00f3n presents, sin\u00f3 tamb\u00e9 de com s’utilitzen de manera din\u00e0mica.<\/p>\n\n\n\n

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Ens preguntem si l’especialitzaci\u00f3 de la barrera hematoencef\u00e0lica es deu no nom\u00e9s a les prote\u00efnes que expressa, sin\u00f3 tamb\u00e9 a com les utilitza<\/em>.<\/p>\n\n\n\n

Daniel Gonzalez-Carter<\/p>\n<\/blockquote>\n\n\n\n

La investigaci\u00f3, publicada a iScience<\/em><\/a>, mostra que les c\u00e8l\u00b7lules endotelials cerebrals, que formen la barrera hematoencef\u00e0lica, presenten un \u00abperfil endoc\u00edtic\u00bb \u00fanic que descriu la velocitat a la qual les prote\u00efnes s’internalitzen, reciclen o degraden; \u00e9s a dir, quant temps romanen actives a la superf\u00edcie cel\u00b7lular. Aquesta propietat, coneguda com a taxa de recanvi endoc\u00edtic <\/strong>(del’angl\u00e8s endoc\u00edtic <\/em>turnover rate<\/em>, <\/em>ETOR), emergeix com un factor clau en l’especialitzaci\u00f3 de la barrera i es veu alterada en condicions inflamat\u00f2ries<\/strong>.<\/p>\n\n\n\n

\u00abMitjan\u00e7ant una col\u00b7laboraci\u00f3 que integra biologia cel\u00b7lular, prote\u00f2mica, bioinform\u00e0tica i matem\u00e0tiques, ens preguntem si l’especialitzaci\u00f3 de la barrera hematoencef\u00e0lica es deu no nom\u00e9s a les prote\u00efnes que expressa, sin\u00f3 tamb\u00e9 a com les utilitza<\/em>\u00ab, explica Daniel Gonzalez-Carter<\/strong>, investigador s\u00e8nior del grup de Bi\u00f2nica Molecular<\/a> de l’IBEC i l\u00edder de l’estudi.<\/p>\n\n\n\n

\u00abAquestes troballes poden ajudar a identificar noves estrat\u00e8gies terap\u00e8utiques per restaurar la salut neurovascular\u00bb<\/em>, afegeix Giuseppe Battaglia<\/strong>, professor de recerca ICREA a l’IBEC, investigador principal del grup de Bi\u00f2nica Molecular i coautor de l’estudi.<\/p>\n\n\n\n

La barrera hematoencef\u00e0lica \u00e9s una interf\u00edcie altament selectiva que protegeix el cervell alhora que permet el pas de nutrients i senyals essencials. Tradicionalment, la seva funci\u00f3 s’ha explicat a partir de la identitat i l’abund\u00e0ncia de les prote\u00efnes presents a la superf\u00edcie de les c\u00e8l\u00b7lules endotelials.<\/p>\n\n\n\n

No obstant aix\u00f2, encara no \u00e9s clar si la regulaci\u00f3 din\u00e0mica d’aquestes prote\u00efnes, l’anomenat perfil ETOR, contribueix a les propietats \u00faniques de les c\u00e8l\u00b7lules endotelials cerebrals. Aix\u00ed mateix, es desconeix si aquesta regulaci\u00f3 din\u00e0mica canvia en condicions patol\u00f2giques i afecta el funcionament de la barrera.<\/p>\n\n\n\n

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Aquestes troballes poden ajudar a identificar noves estrat\u00e8gies terap\u00e8utiques per restaurar la salut neurovascular<\/em><\/p>\n\n\n\n

Giuseppe Battaglia<\/p>\n<\/blockquote>\n\n\n\n

Utilitzant t\u00e8cniques avan\u00e7ades de prote\u00f2mica, l’equip va analitzar com es comporten al llarg del temps gaireb\u00e9 1.000 prote\u00efnes de membrana en c\u00e8l\u00b7lules endotelials de rata procedents del cervell i d’altres \u00f2rgans. Van descobrir que el temps que aquestes prote\u00efnes romanen a la superf\u00edcie cel\u00b7lular<\/strong> constitueix una capa addicional i independent de regulaci\u00f3.<\/p>\n\n\n\n

Els investigadors van identificar un perfil ETOR espec\u00edfic<\/strong> en les c\u00e8l\u00b7lules endotelials cerebrals que les diferencia clarament de les d’altres \u00f2rgans, fins i tot quan la composici\u00f3 proteica \u00e9s relativament similar.<\/p>\n\n\n\n

En concret, les prote\u00efnes implicades en el transport van mostrar taxes de recanvi elevades, cosa que probablement afavoreix un subministrament eficient de nutrients al cervell. Per contra, les prote\u00efnes d’uni\u00f3 cel\u00b7lular, essencials per mantenir l’estanque\u00eftat de la barrera, van presentar taxes de recanvi baixes, cosa que garanteix la seva estabilitat estructural.<\/p>\n\n\n\n

De forma crucial, aquestes din\u00e0miques no estaven correlacionades amb l’abund\u00e0ncia de prote\u00efnes, <\/strong>la qual cosa demostra que l’ETOR constitueix una caracter\u00edstica reguladora independent de la funci\u00f3 endotelial.<\/p>\n\n\n\n

La inflamaci\u00f3 reconfigura el comportament de la barrera<\/strong><\/strong><\/strong><\/h4>\n\n\n\n

L’estudi tamb\u00e9 mostra que la patologia altera aquestes din\u00e0miques. Quan s’exposen a senyals inflamatoris, les c\u00e8l\u00b7lules endotelials cerebrals mantenen una composici\u00f3 proteica global similar, per\u00f2 el seu comportament canvia: el seu perfil ETOR es modifica significativament.<\/p>\n\n\n\n

\u00abObservem que les c\u00e8l\u00b7lules endotelials cerebrals gestionen les prote\u00efnes d’una forma molt espec\u00edfica que les distingeix dels vasos sanguinis de la resta de l’organisme. L’important \u00e9s que aquest comportament especialitzat s’altera durant la inflamaci\u00f3, fent que es comportin m\u00e9s com a vasos sanguinis perif\u00e8rics t\u00edpics i debilitant potencialment la seva capacitat per protegir el cervell\u00bb<\/em>, explica Gonzalez-Carter.<\/p>\n\n\n\n

Aix\u00ed mateix, els investigadors van comprovar que els canvis en l’abund\u00e0ncia de prote\u00efnes reflecteixen principalment respostes immunit\u00e0ries<\/strong>. En canvi, els canvis en l’ETOR revelen processos relacionats amb la remodelaci\u00f3 vascular<\/strong>. Aix\u00f2 suggereix que centrar-se \u00fanicament en els nivells de prote\u00efnes pot fer que es passin per alt mecanismes clau de la malaltia.<\/p>\n\n\n\n

Implicacions per a la salut cerebral i el desenvolupament de ter\u00e0pies<\/strong><\/strong><\/strong><\/h4>\n\n\n\n

Aquestes troballes obren noves vies per comprendre com es regula la barrera hematoencef\u00e0lica tant en condicions normals com patol\u00f2giques. At\u00e8s que aquesta barrera exerceix un paper central en trastorns neurol\u00f2gics \u2014com la malaltia d’Alzheimer, les conseq\u00fc\u00e8ncies de l’ictus o la neuroinflamaci\u00f3, entre d’altres\u2014, identificar els mecanismes que controlen la seva integritat resulta fonamental.<\/p>\n\n\n\n

En posar en relleu l’ETOR com una dimensi\u00f3 reguladora clau, l’estudi tamb\u00e9 podria contribuir a desenvolupar estrat\u00e8gies per restaurar la funci\u00f3 de la barrera, millorar l’administraci\u00f3 de f\u00e0rmacs al cervell i identificar noves dianes terap\u00e8utiques que ajudin a protegir o restablir la salut cerebral.<\/p>\n\n\n\n

\n\n\n\n

Article de refer\u00e8ncia:<\/strong><\/strong><\/strong><\/p>\n\n\n\n

\n\n\n\n

<\/a><\/p>\n\n\n\n

\"\"<\/figure>\n","protected":false},"excerpt":{"rendered":"

Una investigaci\u00f3 liderada per l’Institut de Bioenginyeria de Catalunya (IBEC) revela que la barrera hematoencef\u00e0lica es defineix no nom\u00e9s per les prote\u00efnes que expressa, sin\u00f3 per com les utilitza, a trav\u00e9s d’una propietat din\u00e0mica coneguda com a taxa de recanvi endoc\u00edtic (ETOR). Aquest descobriment mostra que les c\u00e8l\u00b7lules endotelials cerebrals tenen un comportament molecular \u00fanic que les distingeix d’altres vasos sanguinis i que pot alterar-se durant la inflamaci\u00f3. Els resultats aporten nous coneixements sobre com funciona i s’altera aquesta barrera en el context de malalties, cosa que podria ajudar a identificar noves estrat\u00e8gies terap\u00e8utiques per restaurar la salut neurovascular.<\/p>\n","protected":false},"author":37,"featured_media":134606,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[97],"tags":[1106,2002],"post_formats":[],"class_list":["post-134610","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias-de-investigacion","tag-giuseppe-battaglia-es","tag-molecular-bionics-es"],"yoast_head":"\nNou estudi revela com el comportament de les prote\u00efnes impulsa l'especialitzaci\u00f3 de la barrera hematoencef\u00e0lica - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/new-study-reveals-how-protein-behaviour-drives-blood-brain-barrier-specialization\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Nou estudi revela com el comportament de les prote\u00efnes impulsa l'especialitzaci\u00f3 de la barrera hematoencef\u00e0lica - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Una investigaci\u00f3 liderada per l'Institut de Bioenginyeria de Catalunya (IBEC) revela que la barrera hematoencef\u00e0lica es defineix no nom\u00e9s per les prote\u00efnes que expressa, sin\u00f3 per com les utilitza, a trav\u00e9s d'una propietat din\u00e0mica coneguda com a taxa de recanvi endoc\u00edtic (ETOR). Aquest descobriment mostra que les c\u00e8l\u00b7lules endotelials cerebrals tenen un comportament molecular \u00fanic que les distingeix d'altres vasos sanguinis i que pot alterar-se durant la inflamaci\u00f3. 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Alba Tom\u00e1s-Sitjes, Gianluca Arauz-Garofalo, Marina Gay, S\u00f2nia Jari\u00f3, Marta Vilaseca, Valentina Schastlivaia, Maaike Kessen, Nicola Manicardi, Giuseppe Battaglia, Daniel Gonzalez-Carter. Endocytic turnover of endothelial cell-membrane proteins as a driver of rat blood-brain barrier specialization and dysfunction<\/strong>. iScience <\/em>(2026). DOI: https:\/\/doi.org\/10.1016\/j.isci.2026.116231<\/a><\/p>\n\n\n\n