{"id":136519,"date":"2026-10-14T15:55:23","date_gmt":"2026-10-14T13:55:23","guid":{"rendered":"https:\/\/ibecbarcelona.eu\/lab-designed-molecule-reduces-amyloid-beta-the-protein-linked-to-alzheimers-disease-in-mice\/"},"modified":"2026-10-14T16:10:31","modified_gmt":"2026-10-14T14:10:31","slug":"lab-designed-molecule-reduces-amyloid-beta-the-protein-linked-to-alzheimers-disease-in-mice","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/es\/lab-designed-molecule-reduces-amyloid-beta-the-protein-linked-to-alzheimers-disease-in-mice\/","title":{"rendered":"Una mol\u00e9cula dise\u00f1ada en el laboratorio reduce la beta amiloide, la prote\u00edna asociada al alzh\u00e9imer, en ratones"},"content":{"rendered":"\n

A study led by the Institute for Bioengineering of Catalonia (IBEC) identifies a molecule, P33, that partially modulates the enzyme that initiates amyloid beta formation. The results, obtained in cell cultures and in mice, open up a new avenue of chemical research into the disease. <\/strong><\/p>\n\n

\"\"
De izquierda a derecha: Dayaneth J\u00e1come, Jos\u00e9 A. Del R\u00edo and Rosalina Gav\u00edn.<\/figcaption><\/figure>\n

Un equipo de investigaci\u00f3n liderado por el grupo de Neurobiotecnolog\u00eda Molecular y Celular<\/a> del Instituto de Bioingenier\u00eda de Catalu\u00f1a (IBEC)<\/strong>, en colaboraci\u00f3n con el laboratorio de M\u00edriam Royo del Instituto de Qu\u00edmica Avanzada de Catalu\u00f1a (IQAC-CSIC)<\/strong>, la Universitat de Barcelona (UB) y el Instituto de Investigaci\u00f3n Biom\u00e9dica de Barcelona (IRB Barcelona)<\/strong>, ha identificado un p\u00e9ptido sint\u00e9tico que reduce la producci\u00f3n de beta amiloide (A\u03b2). Esta prote\u00edna se acumula en el cerebro en la enfermedad de Alzheimer. El trabajo, publicado en la revista Bioorganic Chemistry<\/em><\/a>, se ha realizado en neuronas en cultivo (in vitro<\/em>) y en un modelo de rat\u00f3n de la enfermedad (in vivo<\/em>). <\/p>\n\n

En la producci\u00f3n de A\u03b2 interviene una enzima, BACE1. Las enzimas son prote\u00ednas que facilitan reacciones qu\u00edmicas en las c\u00e9lulas; en este caso, BACE1 act\u00faa como unas \u00abtijeras\u00bb que cortan otra prote\u00edna y dan lugar a la beta amiloide. Los f\u00e1rmacos dise\u00f1ados para bloquearla por completo no han superado los ensayos cl\u00ednicos, en parte por los efectos secundarios de bloquear tambi\u00e9n otras funciones necesarias de la enzima. El equipo ha probado otra estrategia: ha dise\u00f1ado unos p\u00e9ptidos, peque\u00f1as cadenas como las que forman las prote\u00ednas, y los ha modificado qu\u00edmicamente para que el organismo no los destruya r\u00e1pidamente y para que puedan entrar en las c\u00e9lulas, donde se produce la beta amiloide. <\/p>\n\n

\u201cAnalizamos una biblioteca de 50 de estas mol\u00e9culas en neuronas en cultivo. P33 destac\u00f3 porque reduc\u00eda claramente la beta amiloide sin da\u00f1ar las c\u00e9lulas y, adem\u00e1s, frenaba de forma selectiva la actividad de BACE1 <\/em>,\u201d explica Dayaneth J\u00e1come<\/strong>, primera autora del estudio e investigadora del IBEC.<\/p>\n\n

\n

Nuestros resultados muestran que no es necesario bloquear por completo BACE1 para reducir la producci\u00f3n de beta amiloide, al menos en modelos de laboratorio. Estos p\u00e9ptidos nos ofrecen una plataforma qu\u00edmica vers\u00e1til para seguir investigando esta v\u00eda <\/em>.<\/p>\n\n\n\n

Jos\u00e9 A. Del R\u00edo<\/p>\n<\/blockquote>\n\n

En neuronas de rat\u00f3n en cultivo, P33 redujo la liberaci\u00f3n de A\u03b2 a menos de la mitad sin da\u00f1ar las c\u00e9lulas. Tambi\u00e9n disminuy\u00f3 m\u00e1s de un 50 % la actividad asociada a BACE1, sin afectar significativamente a una enzima muy similar, BACE2. En ratones modificados gen\u00e9ticamente para desarrollar placas de amiloide, la administraci\u00f3n de P33 durante ocho semanas redujo un 35,6 % los niveles de A\u03b2 cerebral y la superficie ocupada por placas en la corteza y el hipocampo. No se detectaron da\u00f1os en otros \u00f3rganos ni cambios en los marcadores de inflamaci\u00f3n analizados. <\/p>\n\n

\u201cNuestros resultados muestran que no es necesario bloquear por completo BACE1 para reducir la producci\u00f3n de beta amiloide, al menos en modelos de laboratorio. Estos p\u00e9ptidos nos ofrecen una plataforma qu\u00edmica vers\u00e1til para seguir investigando esta v\u00eda <\/em>,\u201d explica Jos\u00e9 A. Del R\u00edo<\/strong>, investigador principal del IBEC, catedr\u00e1tico de la Facultad de Biolog\u00eda de la Universidad de Barcelona (UB), miembro del Instituto de Neurociencias (UBneuro) de la Universidad de Barcelona y de CIBERNED y col\u00edder del estudio.<\/p>\n\n

\u201cEstos primeros resultados en ratones abren varias l\u00edneas de trabajo. Ahora queremos ampliar los estudios con un mayor n\u00famero de animales, medir cu\u00e1nto P33 llega al cerebro y confirmar con precisi\u00f3n c\u00f3mo act\u00faa sobre BACE1 <\/em>,\u201d se\u00f1ala Rosalina Gav\u00edn<\/strong>, col\u00edder del estudio, investigadora s\u00e9nior del IBEC, profesora agregada de la UB y miembro de UBneuro y CIBERNED. El equipo tambi\u00e9n quiere comprobar si la tendencia a una mejor memoria que mostraron los ratones tratados se confirma en estudios m\u00e1s amplios. <\/p>\n\n

\n\n

Art\u00edculo referenciado<\/strong><\/p>\n\n

Dayaneth J\u00e1come, Marina P\u00e9rez-Palau, In\u00e9s Mart\u00ednez-Soria, Laia Lid\u00f3n, Cristina Vergara, Daniel Carbajo, Ximena Pulido, Macarena S\u00e1nchez-Navarro, Ernest Giralt, Fernando Albericio, Miriam Royo, Rosalina Gav\u00edn, Jos\u00e9 Antonio Del R\u00edo. cis<\/em>-\u03b3-Amino-L-proline peptides as chemical probes of amyloidogenic processing in neurons and APP\/PS1 mice.<\/strong> Bioorganic Chemistry<\/em> (2026). DOI: https:\/\/doi.org\/10.1016\/j.bioorg.2026.110386<\/a> <\/p>\n\n

\n\n
\"\"<\/figure>","protected":false},"excerpt":{"rendered":"

Un estudio liderado por el Instituto de Bioingenier\u00eda de Catalu\u00f1a (IBEC) identifica una mol\u00e9cula, P33, que modula parcialmente la enzima que inicia la formaci\u00f3n de beta amiloide. Los resultados, obtenidos en cultivos celulares y en ratones, abren una nueva v\u00eda de investigaci\u00f3n qu\u00edmica sobre la enfermedad. <\/p>\n","protected":false},"author":37,"featured_media":136516,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[97],"tags":[1628,1133,1583],"post_formats":[],"class_list":["post-136519","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias-de-investigacion","tag-alzheimer-es-2","tag-jose-antonio-del-rio-es","tag-molecular-and-cellular-neurobiotechnology-group-es"],"yoast_head":"\nUna mol\u00e9cula dise\u00f1ada en el laboratorio reduce la beta amiloide, la prote\u00edna asociada al alzh\u00e9imer, en ratones - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/es\/lab-designed-molecule-reduces-amyloid-beta-the-protein-linked-to-alzheimers-disease-in-mice\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Una mol\u00e9cula dise\u00f1ada en el laboratorio reduce la beta amiloide, la prote\u00edna asociada al alzh\u00e9imer, en ratones - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Un estudio liderado por el Instituto de Bioingenier\u00eda de Catalu\u00f1a (IBEC) identifica una mol\u00e9cula, P33, que modula parcialmente la enzima que inicia la formaci\u00f3n de beta amiloide. 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