{"id":17062,"date":"2015-06-15T11:10:14","date_gmt":"2015-06-15T11:10:14","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=17062"},"modified":"2015-06-15T11:17:27","modified_gmt":"2015-06-15T11:17:27","slug":"las-celulas-utilizan-la-fisica-para-ser-mas-resistentes","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/es\/las-celulas-utilizan-la-fisica-para-ser-mas-resistentes\/","title":{"rendered":"Las c\u00e9lulas utilizan la f\u00edsica para ser m\u00e1s resistentes"},"content":{"rendered":"
C\u00e9lula despu\u00e9s de haber modificado su \u00e1rea y su volumen. En rojo se ven los pliegues que aparecen despu\u00e9s del estiramiento, y en verde los que aparecen tras el choque osm\u00f3tico. En recuadro inferior: zoom y vista vertical de los pliegues.<\/h6>\n

Investigadores del Institut de Bioenginyeria de Catalunya (IBEC), en colaboraci\u00f3n con el Instituto de Mecanobiolog\u00eda de Singapur y la Universidad Polit\u00e9cnica de Barcelona (UPC), han descubierto c\u00f3mo se produce este fen\u00f3meno, demostrando que cada vez que una c\u00e9lula se comprime o estira, forma o elimina peque\u00f1os pliegues en la membrana que evitan que se rasgue.<\/p>\n

Lo fascinante de este sistema es su simplicidad: durante a\u00f1os, multitud de grupos de investigaci\u00f3n en todo el mundo, han buscado complejos procesos bioqu\u00edmicos y moleculares para explicar c\u00f3mo se adapta la membrana. Este estudio, sin embargo, demuestra que aplicando las leyes de la f\u00edsica y la mec\u00e1nica, las c\u00e9lulas pueden adaptarse hasta extremos impensados.<\/p>\n

\u00abDado los continuos cambios de forma celular que ocurren en los procesos cancer\u00edgenos o durante la cicatrizaci\u00f3n de las heridas, las implicaciones que tiene este hallazgo son muy relevantes\u00bb dice Pere Roca-Cusachs, investigador principal del IBEC y profesor lector de la Universidad de Barcelona, que ha liderado el estudio. \u00abEl reto ahora es ver hasta qu\u00e9 punto esta nueva comprensi\u00f3n nos puede permitir interferir en la progresi\u00f3n de tumores, mejorar la regeneraci\u00f3n de tejidos, o solucionar problemas en enfermedades respiratorias y cardiovasculares\u00bb, a\u00f1ade.<\/p>\n

El estudio, que se publica hoy en la revista Nature Communications<\/em>, desvela c\u00f3mo el \u00e1rea de la membrana celular puede aumentar o disminuir para acomodar la forma de la c\u00e9lula de forma pr\u00e1cticamente inmediata, lo cual es esencial en procesos vitales como la respiraci\u00f3n o el latido del coraz\u00f3n.<\/p>\n

\u00abPara realizar este estudio, hemos comprobado la adaptaci\u00f3n de las c\u00e9lulas despu\u00e9s de cambiar su \u00e1rea (estir\u00e1ndolas) y su volumen (introduciendo agua en su interior mediante un choque osm\u00f3tico)\u00bb dice Anita J. Kosmalska, investigadora del IBEC y primera autora del estudio. \u00abEn ambos casos, sin necesidad de tener en cuenta la complejidad biol\u00f3gica de las c\u00e9lulas, las leyes de la mec\u00e1nica y la f\u00edsica por s\u00ed solas son capaces de explicar d\u00f3nde se forman o eliminan pliegues, qu\u00e9 forma tienen, y c\u00f3mo protegen la membrana celular de su ruptura\u00bb, a\u00f1ade.<\/p>\n

—<\/p>\n

Reference article:<\/strong> <\/em>Anita Joanna Kosmalska, Laura Casares, Alberto Elosegui-Artola, Joseph Jose Thottacherry, Roberto Moreno-Vicente, Victor Gonz\u00e1lez-Tarrago, Miguel Angel del Pozo, Satyajit Mayor, Marino Arroyo, Daniel Navajas, Xavier Trepat, Nils C. Gauthier & Pere Roca-Cusachs (2015).\u201cPhysical principles of membrane remodelling during cell mechanoadaptation\u201d. Nature Communications<\/em>, 10.1038\/ncomms8292<\/p>\n","protected":false},"excerpt":{"rendered":"

\"opcioUn estudio del Institut de Bioenginyeria de Catalunya (IBEC) revela c\u00f3mo las c\u00e9lulas evitan romperse durante las continuas deformaciones que sufren en la mayor\u00eda de procesos biol\u00f3gicos<\/h3>\n

Durante procesos biol\u00f3gicos cr\u00edticos como el desarrollo embrionario, la respiraci\u00f3n, el bombeo del coraz\u00f3n, la curaci\u00f3n de heridas o el crecimiento de tumores, millones de c\u00e9lulas se estiran y se deforman para adaptarse a su entorno. La membrana que envuelve la c\u00e9lula, aunque r\u00edgida e inextensible, soporta todas estas deformaciones utilizando un sistema, hasta ahora desconocido, que evita su ruptura.<\/p>\n","protected":false},"author":4,"featured_media":17051,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[97],"tags":[],"post_formats":[],"class_list":["post-17062","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias-de-investigacion"],"yoast_head":"\nLas c\u00e9lulas utilizan la f\u00edsica para ser m\u00e1s resistentes - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/es\/las-celulas-utilizan-la-fisica-para-ser-mas-resistentes\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Las c\u00e9lulas utilizan la f\u00edsica para ser m\u00e1s resistentes - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Un estudio del Institut de Bioenginyeria de Catalunya (IBEC) revela c\u00f3mo las c\u00e9lulas evitan romperse durante las continuas deformaciones que sufren en la mayor\u00eda de procesos biol\u00f3gicos Durante procesos biol\u00f3gicos cr\u00edticos como el desarrollo embrionario, la respiraci\u00f3n, el bombeo del coraz\u00f3n, la curaci\u00f3n de heridas o el crecimiento de tumores, millones de c\u00e9lulas se estiran y se deforman para adaptarse a su entorno. 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