{"id":17990,"date":"2015-07-09T12:55:56","date_gmt":"2015-07-09T12:55:56","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=17990"},"modified":"2016-06-11T18:21:28","modified_gmt":"2016-06-11T18:21:28","slug":"cientificos-del-ibec-asocian-los-ataques-epilepticos-durante-las-enfermedades-neurodegenerativas-a-la-perdida-de-funcion-de-la-proteina-prionica-celular","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/es\/cientificos-del-ibec-asocian-los-ataques-epilepticos-durante-las-enfermedades-neurodegenerativas-a-la-perdida-de-funcion-de-la-proteina-prionica-celular\/","title":{"rendered":"Cient\u00edficos del IBEC asocian los ataques epil\u00e9pticos durante las enfermedades neurodegenerativas a la p\u00e9rdida de funci\u00f3n de la prote\u00edna pri\u00f3nica celular"},"content":{"rendered":"

y sus colaboradores han publicado los hallazgos que podr\u00edan conducir a una mejor comprensi\u00f3n de las enfermedades neurodegenerativas r\u00e1pidas que implican ataques epil\u00e9pticos, como la enfermedad de Creutzfeldt-Jacob (ECJ)<\/p>\n

Imagen: Secci\u00f3n del hipocampo de rat\u00f3n knock-out para dos prote\u00ednas prionicas que sobre expresan una forma truncada de prote\u00edna prionica DF35. A la izquierda, una tinci\u00f3n de Nissl de un rat\u00f3n no-tratado mostrando la estructura t\u00edpica de las capas piramidales de CA1-CA3. A la derecha, una tinci\u00f3n FluoroJade B 24h despu\u00e9s de un tratamiento con KA. La tinci\u00f3n marca espec\u00edficamente la degeneraci\u00f3n neuronal, con lo que el patr\u00f3n neurodegenerativo que se ve est\u00e1 relacionado \u00fanicamente al tratamiento KA, demostrando as\u00ed el papel neuroprotector esencial de la prote\u00edna pri\u00f3nica<\/h6>\n

\u201cDesarrollamos un an\u00e1lisis comparativo de la susceptibilidad de convulsi\u00f3n utilizando ratones con seis herencias gen\u00e9ticas diferentes y varios experimentos in vitro\u201d, dice Jos\u00e9 Antonio del R\u00edo, responsable del grupo de Neurobiotecnolog\u00eda Molecular y Celular del IBEC. \u201cAdem\u00e1s, demostramos que los ratones a los que les faltaba PrPC<\/sup> mostraban un incremento de susceptibilidad a los episodios epil\u00e9pticos que llevan a la muerte celular en la regi\u00f3n del hipocampo, apoyando la idea de que la prote\u00edna est\u00e1 implicada en la neuroprotecci\u00f3n contra convulsiones, y que participa activamente en el incremento de la respuesta epil\u00e9ptica observada en ratones, independientemente de su carga gen\u00e9tica, a los que les faltaba\u00bb.<\/p>\n

La prote\u00edna PrPC<\/sup> se encuentra de forma natural en el cerebro sano y, en menor cantidad, cuando el cerebro est\u00e1 afectado por enfermedades como la encefalopat\u00eda espongiforme bovina o la demencia humana r\u00e1pidamente progresiva. Desde hace tiempo se le reconoce un efecto neuroprotector, y los investigadores del IBEC han llegado a la conclusi\u00f3n de que los s\u00edntomas de las convulsiones en las enfermedades neurodegenerativas est\u00e1n asociados a la p\u00e9rdida de su funci\u00f3n.<\/p>\n

El estudio, que tambi\u00e9n ha involucrado a investigadores de la UB, IDIBELL, CIBERNED, CISA-INIA, DZNE (Alemania) y SISSA (Italia), tambi\u00e9n han revelado que hay otros factores paralelos a la supresi\u00f3n de PrPC<\/sup>, como por ejemplo, la carga gen\u00e9tica de algunos de los ratones utilizados para el an\u00e1lisis de PrPC<\/sup>, o la presencia del denominado \u2018Prnp-flanking genes\u2019 en los ratones knockout<\/em> para PrPC<\/sup>, que pueden contribuir a la susceptibilidad de ataques epil\u00e9pticos en ausencia de PrPC<\/sup>.<\/p>\n

\u201cEn la neurodegeneraci\u00f3n encontrada en casos de demencia r\u00e1pidamente progresiva, CJD, Alzheimer o demencia con cuerpos de Lewy, el tiempo de supervivencia desde el diagn\u00f3stico cl\u00ednico hasta la muerte es muy corto, siendo el temblor y las convulsiones epil\u00e9pticas caracter\u00edsticas comunes de algunas de estas demencias,\u201d dice del R\u00edo. \u201cCon estos nuevos hallazgos, estamos un poco m\u00e1s cerca de comprender m\u00e1s sobre las enfermedades neurodegenerativas que involucran convulsiones epil\u00e9pticas, lo que significa estar un paso m\u00e1s cerca de desarrollar nuevas terapias o herramientas de diagn\u00f3stico.\u201d<\/p>\n

—<\/p>\n

Referencia:<\/strong> Patricia Carulla, Franc Llorens, Andreu Matamoros-Angles, Patricia Aguilar-Calvo, Juan Carlos Espinosa, Rosalina Gav\u00edn, Isidre Ferrer, Giuseppe Legname, Juan Maria Torres & Jos\u00e9 A. del R\u00edo (2015). Involvement of PrPC<\/sup> in kainate-induced excitotoxicity in several mouse strains<\/a>.\u00a0Scientific Reports<\/em>, 5, 11971<\/p>\n","protected":false},"excerpt":{"rendered":"

\"\"Investigadores del Instituto de Bioingenier\u00eda de Catalunya (IBEC) han revelado que la prote\u00edna pri\u00f3nica celular (PrPC) -asociada a una gran cantidad de funciones biol\u00f3gicas, como la proliferaci\u00f3n celular, la diferenciaci\u00f3n y la se\u00f1alizaci\u00f3n- juega un papel determinante en la epilepsia.
\n<\/h3>\n

En la \u00faltima edici\u00f3n de Scientific Reports, revista del grupo Nature, el grupo de Neurobiotecnolog\u00eda Molecular y Celular del IBEC<\/p>\n","protected":false},"author":4,"featured_media":17958,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[97],"tags":[143,142],"post_formats":[],"class_list":["post-17990","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias-de-investigacion","tag-epilepsia","tag-neurodegeneracion"],"yoast_head":"\nCient\u00edficos del IBEC asocian los ataques epil\u00e9pticos durante las enfermedades neurodegenerativas a la p\u00e9rdida de funci\u00f3n de la prote\u00edna pri\u00f3nica celular - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/es\/cientificos-del-ibec-asocian-los-ataques-epilepticos-durante-las-enfermedades-neurodegenerativas-a-la-perdida-de-funcion-de-la-proteina-prionica-celular\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cient\u00edficos del IBEC asocian los ataques epil\u00e9pticos durante las enfermedades neurodegenerativas a la p\u00e9rdida de funci\u00f3n de la prote\u00edna pri\u00f3nica celular - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Investigadores del Instituto de Bioingenier\u00eda de Catalunya (IBEC) han revelado que la prote\u00edna pri\u00f3nica celular (PrPC) -asociada a una gran cantidad de funciones biol\u00f3gicas, como la proliferaci\u00f3n celular, la diferenciaci\u00f3n y la se\u00f1alizaci\u00f3n- juega un papel determinante en la epilepsia. 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