{"id":19161,"date":"2015-10-12T11:00:29","date_gmt":"2015-10-12T11:00:29","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=19161"},"modified":"2016-06-08T09:40:45","modified_gmt":"2016-06-08T09:40:45","slug":"possible-new-treatment-for-bladder-cancer-using-a-mycobacterium","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/es\/possible-new-treatment-for-bladder-cancer-using-a-mycobacterium\/","title":{"rendered":"Possible new treatment for bladder cancer using a mycobacterium"},"content":{"rendered":"<p>A study of the characteristics of a wide group of mycobacteria begun seven years ago by the Mycobacteria Research Group, led by Dr. Esther Juli\u00e1n of the Department of Genetics and Microbiology, Universitat Aut\u00f2noma de Barcelona (UAB), has discovered that one of these, <em>Mycobacterium brumae (M.\u00a0 brumae)<\/em>, is able to reduce the growth of tumour cells in the bladder and activate an immune response.<\/p>\n<p>Pre-clinical studies using mouse models of bladder cancer have demonstrated the efficacy of the mycobacterium <em>M. brumae<\/em> in the treatment of this disease. Mice with bladder tumours that are treated with <em>M. brumae<\/em> in the same way as patients survive longer than untreated mice and, what&#8217;s more, in larger numbers than those treated with the usual mycobacterium, BCG. The studies conducted at the UAB have shown that <em>M. brumae<\/em> is not pathogenic, presenting no risk of causing infections, which means it would have fewer adverse side effects on patients than BCG.<\/p>\n<p>Furthermore, the fact that <em>M. brumae<\/em> is a rapid-growth, non-pathogenic mycobacterium makes it easier and quicker to produce on a large scale than BCG, which is significant given that in the last few years BCG production problems have led to supply issues for certain bladder cancer patients. \u201cOur results suggest that\u00a0<em>Mycobacterium brumae<\/em> is an ideal candidate to replace the current BCG treatment for superficial bladder cancer,\u00bb concludes Dr. Juli\u00e1n.<\/p>\n<p>The study, published in the journal <em>European Urology Focus,<\/em> was conducted in collaboration with Rosa M. Rabanal of the Murine and Comparative Pathology Unit, Department of Animal Medicine and Surgery, UAB, and with the <a href=\"https:\/\/ibecbarcelona.eu\/bactinf\">Bacterial Infections: Antimicrobial Therapies group<\/a> led by Eduard Torrents at the Institute for Bioengineering of Catalonia (IBEC).<\/p>\n<p><em><strong>Original article:<\/strong><\/em><br \/>\nNoguera-Ortega E, Secanella-Fandos S, Era\u00f1a H, Gasi\u00f3n J, Rabanal RM, Luquin M, Torrents E, and Juli\u00e1n E. (2015). <a href=\"http:\/\/www.europeanurology.com\/article\/S2405-4569%2815%2900021-8\/abstract\/nonpathogenic-mycobacterium-brumae-inhibits-bladder-cancer-growth-in-vitro-ex-vivo-and-in-vivo\">The non-pathogenic Mycobacterium brumae inhibits bladder cancer growth in vitro, ex vivo, and in vivo. <\/a>European Urology FOCUS. DOI: 10.1016\/j.euf.2015.03.003.<\/p>\n","protected":false},"excerpt":{"rendered":"<h3><img decoding=\"async\" data-src=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2015\/10\/Micobacteriumbrumae.jpg\" alt=\"\" width=\"400\" height=\"373\" class=\"left size-full wp-image-19121 lazyload\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 400px; --smush-placeholder-aspect-ratio: 400\/373;\" \/>Collaborators at the UAB and IBEC have found a mycobacterium that is more effective in treating superficial bladder cancer and does not cause infections, unlike those used up to now. <\/h3>\n<p>Mycobacteria are the only bacteria used in cancer treatment. The administration of the bacterium <em>Mycobacterium bovis<\/em> (BCG) is the current treatment for superficial bladder cancer, and is inserted directly into the bladder through a catheter. BCG prevents new tumours from appearing, but despite its efficacy it has many adverse side effects, the most serious being BCG infections that need to be treated with antituberculous drugs. <\/p>\n","protected":false},"author":4,"featured_media":19157,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[97],"tags":[],"post_formats":[],"class_list":["post-19161","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias-de-investigacion"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Possible new treatment for bladder cancer using a mycobacterium - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/es\/possible-new-treatment-for-bladder-cancer-using-a-mycobacterium\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Possible new treatment for bladder cancer using a mycobacterium - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Collaborators at the UAB and IBEC have found a mycobacterium that is more effective in treating superficial bladder cancer and does not cause infections, unlike those used up to now.   Mycobacteria are the only bacteria used in cancer treatment. The administration of the bacterium Mycobacterium bovis (BCG) is the current treatment for superficial bladder cancer, and is inserted directly into the bladder through a catheter. BCG prevents new tumours from appearing, but despite its efficacy it has many adverse side effects, the most serious being BCG infections that need to be treated with antituberculous drugs.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ibecbarcelona.eu\/es\/possible-new-treatment-for-bladder-cancer-using-a-mycobacterium\/\" \/>\n<meta property=\"og:site_name\" content=\"Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"article:published_time\" content=\"2015-10-12T11:00:29+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2016-06-08T09:40:45+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2015\/10\/Micobacteriumbrumae.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"768\" \/>\n\t<meta property=\"og:image:height\" content=\"1000\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"\u00c0ngels L\u00f3pez\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"\u00c0ngels L\u00f3pez\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/possible-new-treatment-for-bladder-cancer-using-a-mycobacterium\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/possible-new-treatment-for-bladder-cancer-using-a-mycobacterium\\\/\"},\"author\":{\"name\":\"\u00c0ngels L\u00f3pez\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/person\\\/c212c6b589546130be67986b9290e2b8\"},\"headline\":\"Possible new treatment for bladder cancer using a mycobacterium\",\"datePublished\":\"2015-10-12T11:00:29+00:00\",\"dateModified\":\"2016-06-08T09:40:45+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/possible-new-treatment-for-bladder-cancer-using-a-mycobacterium\\\/\"},\"wordCount\":331,\"publisher\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/possible-new-treatment-for-bladder-cancer-using-a-mycobacterium\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2015\\\/10\\\/Micobacteriumbrumae.jpg\",\"articleSection\":[\"Noticias de investigaci\u00f3n\"],\"inLanguage\":\"es\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/possible-new-treatment-for-bladder-cancer-using-a-mycobacterium\\\/\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/possible-new-treatment-for-bladder-cancer-using-a-mycobacterium\\\/\",\"name\":\"Possible new treatment for bladder cancer using a mycobacterium - 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