{"id":20275,"date":"2015-12-11T10:44:35","date_gmt":"2015-12-11T10:44:35","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=20275"},"modified":"2015-12-16T09:02:07","modified_gmt":"2015-12-16T09:02:07","slug":"aprovechamiento-de-e-coli-micromotores-para-la-liberacion-de-farmacos","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/es\/aprovechamiento-de-e-coli-micromotores-para-la-liberacion-de-farmacos\/","title":{"rendered":"Aprovechamiento de E. coli micromotores para la liberaci\u00f3n de f\u00e1rmacos"},"content":{"rendered":"<h6 class=\"caption\" style=\"padding: 0px 10px 10px 30px;\">Imagen: im\u00e1genes de SEM de E.coli unidas a part\u00edculas Janus<\/h6>\n<p>Bacterias como <em>E. coli <\/em>\u2013 que es m\u00e1s conocida como la bacteria que causa la intoxicaci\u00f3n alimentaria, aunque un tipo de esta bacteria que no es pat\u00f3geno se produce de forma natural en el intestino, al igual que un sinn\u00famero de otros tipos de bacterias que forman parte de la flora intestinal de nuestro cuerpo \u2013 pueden ser aprovechadas para alimentar estos micromotores en el interior del organismo convirtiendo la energ\u00eda qu\u00edmica envolvente en trabajo mec\u00e1nico. Adem\u00e1s se pueden considerar combustibles bioresponsables, ya que mientras hasta ahora los micromotores depend\u00edan de combustibles y materiales t\u00f3xicos para el organismo cosa que no los hac\u00eda compatibles par aplicaciones biom\u00e9dicas.<\/p>\n<p>Para conseguir los micromotores propulsados por bacterias, los investigadores han integrado la <em>E. coli <\/em>en las part\u00edculas de metal encapsulado y poliestireno Janus \u2013 un tipo especial de part\u00edculas cuya superficie tiene dos o m\u00e1s propiedades f\u00edsicas diferentes. <em>E. coli <\/em>\u00a0prefiere el platino sobre todos los tipos de metal probados, y se adhiere solo al lado del metal, permitiendo que la superficie de poliestireno de la part\u00edcula se pueda utilizar para unir el f\u00e1rmaco. \u201cNuestro bio-h\u00edbrido ha sido capaz de transportar una carga de hasta 2 \u00b5m de di\u00e1metro, y demostrar la habilidad de transportar DOX, un f\u00e1rmaco anticancer\u00edgeno,\u201d dice Samuel.<\/p>\n<p>El bio-h\u00edbrido tiene la doble capacidad \u2013 guiar la adhesi\u00f3n celular y localizar la uni\u00f3n del f\u00e1rmaco \u2013 as\u00ed como es capad de nadar en un micro-ambiente delimitado que de otro modo ser\u00eda inaccesible. Los retos de futuro para los micromotores alimentados con bacterias es ser operados en sistemas <em>in vivo <\/em>\u00a0con un ambiente tridimensional m\u00e1s complejo, pero para tener \u00e9xito es esencial un mayor conocimiento de la interacci\u00f3n bacteria-superficie.<\/p>\n<p>&#8212;<\/p>\n<p>Art\u00edculos: Morgan M. Stanton, Juliane Simmchen, Xing Ma, Albert Miguel-L\u00f3pez, Samuel S\u00e1nchez* (2015). <a href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/admi.201500505\/abstract\">Bio-hybrid Janus Motors Driven by Escherichia coli.<\/a> <em>Adv Mat Interfaces<\/em>, epub head of print<\/p>\n","protected":false},"excerpt":{"rendered":"<h3><img decoding=\"async\" data-src=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2015\/12\/Samuel-Sanchez-Adv-Mat-2015.jpg\" alt=\"Samuel Sanchez Adv Mat 2015\" width=\"400\" height=\"329\" class=\"left size-full wp-image-20254 lazyload\" data-srcset=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2015\/12\/Samuel-Sanchez-Adv-Mat-2015.jpg 400w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2015\/12\/Samuel-Sanchez-Adv-Mat-2015-300x247.jpg 300w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2015\/12\/Samuel-Sanchez-Adv-Mat-2015-158x130.jpg 158w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2015\/12\/Samuel-Sanchez-Adv-Mat-2015-150x123.jpg 150w\" data-sizes=\"(max-width: 400px) 100vw, 400px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 400px; --smush-placeholder-aspect-ratio: 400\/329;\" \/>Un investigador del IBEC y sus colaboradores han dado el \u00faltimo paso para conseguir micromotores seguros para transportar y liberar f\u00e1rmacos mediante el desarrollo de una versi\u00f3n que se alimenta de bacterias.<\/h3>\n<p>Samuel Sanchez, quien recientemente ha publicado un trabajo similar sobre micro transportadores de f\u00e1rmacos que utilizan enzimas que consumen combustibles biol\u00f3gicos, como el az\u00facar, ha trabajado con parte de su equipo en el Max Planck Institute for Intelligent Systems en este \u00faltimo descubrimiento, que elabora una opci\u00f3n a\u00fan m\u00e1s prometedora alimentada por <em>Escherichia coli<\/em>.<\/p>\n","protected":false},"author":4,"featured_media":20255,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[97],"tags":[],"post_formats":[],"class_list":["post-20275","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias-de-investigacion"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Aprovechamiento de E. coli micromotores para la liberaci\u00f3n de f\u00e1rmacos - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/es\/aprovechamiento-de-e-coli-micromotores-para-la-liberacion-de-farmacos\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Aprovechamiento de E. coli micromotores para la liberaci\u00f3n de f\u00e1rmacos - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Un investigador del IBEC y sus colaboradores han dado el \u00faltimo paso para conseguir micromotores seguros para transportar y liberar f\u00e1rmacos mediante el desarrollo de una versi\u00f3n que se alimenta de bacterias.  Samuel Sanchez, quien recientemente ha publicado un trabajo similar sobre micro transportadores de f\u00e1rmacos que utilizan enzimas que consumen combustibles biol\u00f3gicos, como el az\u00facar, ha trabajado con parte de su equipo en el Max Planck Institute for Intelligent Systems en este \u00faltimo descubrimiento, que elabora una opci\u00f3n a\u00fan m\u00e1s prometedora alimentada por Escherichia coli.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ibecbarcelona.eu\/es\/aprovechamiento-de-e-coli-micromotores-para-la-liberacion-de-farmacos\/\" \/>\n<meta property=\"og:site_name\" content=\"Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"article:published_time\" content=\"2015-12-11T10:44:35+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2015-12-16T09:02:07+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2015\/12\/Samuel-Sanchez-Adv-Mat-2015.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"400\" \/>\n\t<meta property=\"og:image:height\" content=\"329\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"\u00c0ngels L\u00f3pez\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"\u00c0ngels L\u00f3pez\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/aprovechamiento-de-e-coli-micromotores-para-la-liberacion-de-farmacos\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/aprovechamiento-de-e-coli-micromotores-para-la-liberacion-de-farmacos\\\/\"},\"author\":{\"name\":\"\u00c0ngels L\u00f3pez\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/person\\\/c212c6b589546130be67986b9290e2b8\"},\"headline\":\"Aprovechamiento de E. coli micromotores para la liberaci\u00f3n de f\u00e1rmacos\",\"datePublished\":\"2015-12-11T10:44:35+00:00\",\"dateModified\":\"2015-12-16T09:02:07+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/aprovechamiento-de-e-coli-micromotores-para-la-liberacion-de-farmacos\\\/\"},\"wordCount\":356,\"publisher\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/aprovechamiento-de-e-coli-micromotores-para-la-liberacion-de-farmacos\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2015\\\/12\\\/Samuel-Sanchez-Adv-Mat-2015.jpg\",\"articleSection\":[\"Noticias de investigaci\u00f3n\"],\"inLanguage\":\"es\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/aprovechamiento-de-e-coli-micromotores-para-la-liberacion-de-farmacos\\\/\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/aprovechamiento-de-e-coli-micromotores-para-la-liberacion-de-farmacos\\\/\",\"name\":\"Aprovechamiento de E. coli micromotores para la liberaci\u00f3n de f\u00e1rmacos - 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