{"id":20346,"date":"2015-12-17T10:29:38","date_gmt":"2015-12-17T10:29:38","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=20346"},"modified":"2015-12-21T08:31:57","modified_gmt":"2015-12-21T08:31:57","slug":"propiedades-de-las-microondas-electromagneticas-de-celulas-bacterianas-individuales-medidas-por-primera-vez","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/es\/propiedades-de-las-microondas-electromagneticas-de-celulas-bacterianas-individuales-medidas-por-primera-vez\/","title":{"rendered":"Propiedades electromagn\u00e9ticas de c\u00e9lulas bacterianas individuales a frecuencias de microondas medidas por primera vez"},"content":{"rendered":"<h6 class=\"caption\" style=\"padding: 0px 10px 10px 30px;\"><em>Imagen: c\u00f3mo la microscop\u00eda de barrido de microondas mide la permitividad el\u00e9ctrica de un objeto biol\u00f3gico a escala nanom\u00e9trica<\/em><\/h6>\n<p>Habiendo medido las bajas frecuencias (kHz) de la polarizabilidad el\u00e9ctrica del ADN y de c\u00e9lulas bacterianas individuales en 2014 y de los principales componentes de la membrana celular, este a\u00f1o el grupo de Caracterizaci\u00f3n Bioel\u00e9ctrica a la Nanoescala ha conseguido este novedoso avance mediante el uso de una t\u00e9cnica conocida como microscop\u00eda de barrido de microondas. Con esta t\u00e9cnica una \u00fanica c\u00e9lula o microorganismo, en este caso una c\u00e9lula bacteriana, puede fotografiarse utilizando microondas, similares a las que se usan en la telefon\u00eda m\u00f3vil para comunicarnos o en los microondas, y as\u00ed cuantificar a la nanoescala las propiedades electromagn\u00e9ticas con gran precisi\u00f3n y reproducibilidad.<\/p>\n<p>\u201cNuevos avances en t\u00e9cnicas de imagen m\u00e9dica no-invasivas para el diagn\u00f3stico de c\u00e1ncer, t\u00e9cnicas de ablaci\u00f3n terap\u00e9uticas para el tratamiento del c\u00e1ncer y novedosas t\u00e9cnicas de electrocirug\u00eda est\u00e1n en proceso de desarrollo bas\u00e1ndose en el uso se las microondas y en el conocimiento de las propiedades electromagn\u00e9ticas de alta frecuencia &#8211; la permitividad compleja &#8211; de los tejidos biol\u00f3gicos,\u00bb explica Gabriel Gomila, quien lider\u00f3 la investigaci\u00f3n. \u00abAhora, hemos demostrado la posibilidad de medir estas propiedades f\u00edsicas clave tambi\u00e9n a nivel unicelular, lo que nos proporciona un mayor conocimiento sobre la interacci\u00f3n de las microondas con los entes biol\u00f3gicos y allana el camino hacia nuevas aplicaciones m\u00e9dicas de las microondas.\u00bb<\/p>\n<p>Los investigadores han cuantificado la permitividad el\u00e9ctrica de una c\u00e9lula individual de <em>Escherichia coli<\/em>, demostrando as\u00ed que su t\u00e9cnica puede detectar la presencia de estructuras a escalas muy peque\u00f1as incluso en el interior de los microorganismos, proporcionando as\u00ed un sinf\u00edn de aplicaciones en el escaneo sin etiquetas de c\u00e9lulas bacterianas individuales en alta resoluci\u00f3n espacial, y en general, en c\u00e9lulas eucariotas.<\/p>\n<p>\u201cRevelar la permitividad compleja de una \u00fanica c\u00e9lula puede proporcionar informaci\u00f3n \u00fanica sobre su estructura interna y la composici\u00f3n bioqu\u00edmica, y sobre su estado y fase,\u201d dice Gabriel. \u201cEsto tambi\u00e9n puede usarse para dise\u00f1ar e implementar t\u00e9cnicas el\u00e9ctricas sin etiquetas para el recuento, la medida, la separaci\u00f3n y la identificaci\u00f3n de c\u00e9lulas, por lo tanto puede abrir a\u00fan m\u00e1s v\u00edas hacia nuevas y mejoradas aplicaciones biol\u00f3gicas y m\u00e9dicas.\u201d<\/p>\n<p>&#8212;<\/p>\n<p>Maria Chiara Biagi, Ren\u00e9 F\u00e1bregas, Georg Gramse, Marc Van Der Hofstadt, Antonio Ju\u00e1rez, Ferry Kienberger, Laura Fumagalli and Gabriel Gomila (2015). <a href=\"http:\/\/pubs.acs.org\/doi\/abs\/10.1021\/acsnano.5b04279\">\u201cNanoscale electric permittivity of single bacterial cells at GHz frequencies by scanning microwave microscopy\u201d<\/a>. <em>ACS Nano<\/em>, epub ahead of print<\/p>\n","protected":false},"excerpt":{"rendered":"<h3><img decoding=\"async\" data-src=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2015\/12\/acsgomila.jpg\" alt=\"acsgomila\" width=\"398\" height=\"250\" class=\"left size-full wp-image-20288 lazyload\" data-srcset=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2015\/12\/acsgomila.jpg 398w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2015\/12\/acsgomila-300x188.jpg 300w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2015\/12\/acsgomila-207x130.jpg 207w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2015\/12\/acsgomila-150x94.jpg 150w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2015\/12\/acsgomila-318x201.jpg 318w\" data-sizes=\"(max-width: 398px) 100vw, 398px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 398px; --smush-placeholder-aspect-ratio: 398\/250;\" \/>Investigadores del IBEC y sus colaboradores de la Johannes Kepler University de Linz, la Universidad de Manchester y la compa\u00f1\u00eda Keysight Technologies han conseguido un objetivo dif\u00edcil de alcanzar: medir las propiedades electromagn\u00e9ticas de materiales biol\u00f3gicos al nivel de c\u00e9lulas bacterianas individuales y a frecuencias muy altas (gigahercios). <\/h3>\n","protected":false},"author":4,"featured_media":20289,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[97],"tags":[],"post_formats":[],"class_list":["post-20346","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias-de-investigacion"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Propiedades electromagn\u00e9ticas de c\u00e9lulas bacterianas individuales a frecuencias de microondas medidas por primera vez - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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