{"id":20440,"date":"2015-12-22T12:28:15","date_gmt":"2015-12-22T12:28:15","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=20440"},"modified":"2016-06-11T18:30:55","modified_gmt":"2016-06-11T18:30:55","slug":"tecnologias-de-disminucion-para-profundizar-en-los-secretos-del-organismo","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/es\/tecnologias-de-disminucion-para-profundizar-en-los-secretos-del-organismo\/","title":{"rendered":"Tecnolog\u00edas de disminuci\u00f3n para profundizar en los secretos del organismo"},"content":{"rendered":"

En el proyecto, liderado por el Consejo Superior de Investigaciones Cient\u00edficas (CSIC), ha participado Juan Pablo Agusil, quien durante el estudio desarrollaba su labor cient\u00edfica en el Instituto de Bioingenier\u00eda de Catalu\u00f1a (IBEC) y en la actualidad pertenece al Instituto de Microelectr\u00f3nica de Barcelona, del CSIC. En el trabajo tambi\u00e9n ha colaborado el Centro de Investigaciones Biol\u00f3gicas de Madrid, del CSIC, y el Instituto de Nanociencia y Nanotecnolog\u00eda, de la Universidad de Barcelona.<\/p>\n

\u201cLas dos metodolog\u00edas previas, Planar array chips<\/em> y Suspension arrays of particles<\/em>, se han usado durante mucho tiempo para estudiar las interacciones biomoleculares y llevar a cabo an\u00e1lisis moleculares complejos\u201d, explica Juan Pablo. \u201cPero aunque la tecnolog\u00eda Planar array chips<\/em> era buena para la multiplexaci\u00f3n molecular -probar una serie de componentes independientes en una \u00fanica plataforma para la r\u00e1pida identificaci\u00f3n individual de m\u00faltiples elementos- el dispositivo era demasiado grande para vol\u00famenes excepcionalmente peque\u00f1os; y al rev\u00e9s, aunque que la tecnolog\u00eda Suspension arrays of particles<\/em> permit\u00eda el an\u00e1lisis de vol\u00famenes peque\u00f1os, no permit\u00eda la detecci\u00f3n m\u00faltiple en un \u00fanico dispositivo.<\/p>\n

Para solucionar esto, los investigadores han combinado los aspectos ventajosos de ambas t\u00e9cnicas para desarrollar la nueva tecnolog\u00eda Suspended Planar-Array chips<\/em>, que s\u00ed que es capaz de combinar la multiplexaci\u00f3n molecular con los vol\u00famenes excepcionalmente peque\u00f1os. B\u00e1sicamente, han miniaturizado una matriz plana t\u00edpica a una escala de 1010<\/sup>. \u201cUtilizando solo uno de estos dispositivos nosotros podemos entrar en la c\u00e9lula y realizar detecciones m\u00faltiples de par\u00e1metros biol\u00f3gicos\u201d, dice Juan Pablo Agusil. \u201cEsta es la primera vez que la multiplexaci\u00f3n se ha hecho en el interior de una c\u00e9lula viva\u201d.<\/p>\n

Utilizando sus chips, los investigadores ya han demostrado que el movimiento de iones de hidr\u00f3geno a trav\u00e9s de las membranas celulares de c\u00e9lulas HeLa, abriendo as\u00ed el camino para estudios futuros de m\u00faltiples fen\u00f3menos moleculares que suceden en el interior celular de forma simult\u00e1nea. \u201cLa naturaleza interdisciplinar, la versatilidad y el potencial de nuestra t\u00e9cnica puede ser de gran inter\u00e9s para los cient\u00edficos que trabajan en muchas disciplinas diferentes como los biomateriales, la ingenier\u00eda, la tecnolog\u00eda de chips, la impresi\u00f3n o\u00a0 el autoensamblaje de nanocapas, la biolog\u00eda celular y la nanotecnolog\u00eda\u201d, dice Juan Pablo.<\/p>\n

—<\/p>\n

N\u00faria Torras, Juan Pablo Agusil, Patricia V\u00e1zquez, Marta Duch, Alberto M. Hern\u00e1ndez-Pinto, Josep Samitier, Enrique J. de la Rosa, Jaume Esteve, Teresa Su\u00e1rez, Llu\u00efsa P\u00e9rez-Garc\u00eda and Jos\u00e9 A. Plaza (2015). Suspended Planar-Array Chips for Molecular Multiplexing at the Microscale<\/a>. Advanced Materials<\/em>, 17;28(7):1449-54<\/p>\n

—<\/p>\n

IBEC en los Medios:<\/strong> http:\/\/www.larazon.es\/sociedad\/ciencia\/desarrollan-chips-miniaturizados-capaces-de-detectar-enfermedades-desde-el-interior-de-la-celula-viva-DD11479802#.Ttt14cfhFOMbXpr<\/a> http:\/\/www.elpuntavui.cat\/societat\/article\/15-ciencia\/924253-xips-miniaturitzats-per-detectar-malalties.html<\/a> 2015 12 17 JPAgusil DiarioMedico<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

\"AdvancedUn equipo de investigadores con participaci\u00f3n del IBEC ha desarrollado una nueva t\u00e9cnica que miniaturiza la manera en la que se estudian las interacciones biomoleculares, permitiendo por primera vez hacer an\u00e1lisis en el interior de las c\u00e9lulas vivas.<\/h3>\n

El estudio, publicado hoy en la revista Advanced Materials<\/em>, describe una nueva tecnolog\u00eda llamada Suspended Planar-Array chips, cuyo extraordinario grado de miniaturizaci\u00f3n permite su uso a la microescala. La nueva t\u00e9cnica utiliza un \u00fanico chip para identificar, cuantificar y determinar los cambios bioqu\u00edmicos y fisiol\u00f3gicos en vol\u00famenes peque\u00f1os, una reducci\u00f3n tan grande que incluso permite el an\u00e1lisis en el interior de las c\u00e9lulas vivas. <\/p>\n","protected":false},"author":4,"featured_media":20388,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[97],"tags":[],"post_formats":[],"class_list":["post-20440","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias-de-investigacion"],"yoast_head":"\nTecnolog\u00edas de disminuci\u00f3n para profundizar en los secretos del organismo - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/es\/tecnologias-de-disminucion-para-profundizar-en-los-secretos-del-organismo\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Tecnolog\u00edas de disminuci\u00f3n para profundizar en los secretos del organismo - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Un equipo de investigadores con participaci\u00f3n del IBEC ha desarrollado una nueva t\u00e9cnica que miniaturiza la manera en la que se estudian las interacciones biomoleculares, permitiendo por primera vez hacer an\u00e1lisis en el interior de las c\u00e9lulas vivas. El estudio, publicado hoy en la revista Advanced Materials, describe una nueva tecnolog\u00eda llamada Suspended Planar-Array chips, cuyo extraordinario grado de miniaturizaci\u00f3n permite su uso a la microescala. 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