{"id":21637,"date":"2016-02-11T10:55:27","date_gmt":"2016-02-11T09:55:27","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=21637"},"modified":"2016-06-20T15:25:10","modified_gmt":"2016-06-20T13:25:10","slug":"jugando-con-lego-molecular-para-construir-la-proxima-generacion-de-vectores-administradores-de-farmacos","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/es\/jugando-con-lego-molecular-para-construir-la-proxima-generacion-de-vectores-administradores-de-farmacos\/","title":{"rendered":"Jugando con Lego molecular para construir la pr\u00f3xima generaci\u00f3n de vectores administradores de f\u00e1rmacos"},"content":{"rendered":"

\u00abNos centramos en pol\u00edmeros supramoleculares, una familia emergente de estructuras nanom\u00e9tricas con muchos usos potenciales en la qu\u00edmica de materiales y medicamentos, a fin de prepararlos\u00bb, dice Lorenzo. \u00abPor lo general, las nanopart\u00edculas que se est\u00e1n desarrollando para la administraci\u00f3n de f\u00e1rmacos son esf\u00e9ricas, pero nuestras part\u00edculas son en forma de fibra.\u00bb<\/p>\n

Uno de estos pol\u00edmeros, el BTA, es un bloque de construcci\u00f3n vers\u00e1til capaz de auto-ensamblarse en agregados unidimensionales en agua. Esta t\u00e9cnica puede explotar el enfoque modular \u00fanico de la qu\u00edmica supramolecular, los investigadores pudieron montar pol\u00edmeros BTA neutros y con carga positiva y as\u00ed controlar las propiedades globales del pol\u00edmero mediante una simple mezcla de mon\u00f3meros – mol\u00e9culas que se unen qu\u00edmicamente a otras.<\/p>\n

\u00abEsta modularidad \u00fanica significa b\u00e1sicamente que disponemos de una biblioteca de bloques de construcci\u00f3n – un poco como un cubo grande lleno de ladrillos de Lego de diferentes colores – y podemos combinarlos simplemente mezclando los que nos gustan en un mismo vial\u00bb, explica Lorenzo. \u00abEsto es posible debido a que los ladrillos se auto-ensamblan, significa que espont\u00e1neamente se unen para formar la fibra. Por ejemplo, si se echa en el vial un 50% de ladrillos \u00abrojos\u00bb y el otro 50% de ladrillos \u00abverdes\u00bb, encontraremos estos ladrillos formando parte de la fibra sin ning\u00fan esfuerzo, ya que el material se construye a si mismo. Los diferentes ladrillos pueden tener diferentes propiedades qu\u00edmicas (por ejemplo) o funcionalidades de carga diferentes (por ejemplo, f\u00e1rmacos o agentes de orientaci\u00f3n). De esta manera, podemos tratar una gran cantidad de combinaciones de ladrillos, y comprobar cu\u00e1l funciona mejor para la entrega del f\u00e1rmaco\u00bb.<\/p>\n

Las propiedades especiales de los pol\u00edmeros supramoleculares tambi\u00e9n implican que los pol\u00edmeros pueden llevar m\u00e1s de un tipo de f\u00e1rmaco. \u00abLos pol\u00edmeros BTA contienen dos compartimientos que pueden ser usados para el suministro intracelular,\u00bb a\u00f1ade Lorenzo. \u00abCompuestos hidr\u00f3fobos peque\u00f1os pueden ser encapsulados en el n\u00facleo lip\u00f3filo, mientras que siRNA puede ser condensado en el exterior a trav\u00e9s de interacciones electrost\u00e1ticas.\u00bb<\/p>\n

Los cient\u00edficos demostraron que tanto el siRNA y la mol\u00e9cula hidr\u00f3foba fueron entregados con \u00e9xito a las c\u00e9lulas vivas. Con la adecuaci\u00f3n de la plataforma BATA supramolecular para la entrega intracelular se confirma, el estudio representa un paso importante en la b\u00fasqueda para desarrollar, portadores de f\u00e1rmacos, eficaces adaptadas no t\u00f3xicos, y allana el camino para futuras investigaciones.<\/p>\n

—<\/p>\n

Maarten H. Bakker, Cameron C. Lee, E.W. Meijer, Patricia Y.W. Dankers and Lorenzo Albertazzi (2016). \u201cMulticomponent Supramolecular Polymers as a Modular Platform for Intracellular Delivery\u201d<\/a>. ACS Nano<\/em>, 10<\/span> (2), pp 1845\u20131852<\/p>\n","protected":false},"excerpt":{"rendered":"

\"albertazzi<\/a>El potencial terap\u00e9utico de muchos f\u00e1rmacos se ve entorpecido porque los ri\u00f1ones lo eliminan demasiado r\u00e1pidamente, tienen propiedades indeseables, no son selectivos o no entran correctamente en el interior celular.<\/h3>\n

Ahora, el nuevo investigador principal j\u00fanior del IBEC, Lorenzo Albertazzi, y sus ex compa\u00f1eros de la Universidad de Tecnolog\u00eda de Eindhoven, que trabajan junto con Novartis, un socio en la industria, han dado un salto en el \u00e1mbito de los vectores administradores de f\u00e1rmacos mediante el desarrollo de un nuevo tipo de veh\u00edculo con algunas mejoras innovadoras.<\/p>\n","protected":false},"author":4,"featured_media":21584,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[97],"tags":[],"post_formats":[],"class_list":["post-21637","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias-de-investigacion"],"yoast_head":"\nJugando con Lego molecular para construir la pr\u00f3xima generaci\u00f3n de vectores administradores de f\u00e1rmacos - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, 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que trabajan junto con Novartis, un socio en la industria, han dado un salto en el \u00e1mbito de los vectores administradores de f\u00e1rmacos mediante el desarrollo de un nuevo tipo de veh\u00edculo con algunas mejoras innovadoras.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ibecbarcelona.eu\/es\/jugando-con-lego-molecular-para-construir-la-proxima-generacion-de-vectores-administradores-de-farmacos\/\" \/>\n<meta property=\"og:site_name\" content=\"Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"article:published_time\" content=\"2016-02-11T09:55:27+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2016-06-20T13:25:10+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2016\/02\/albertazzi-ACS-nano.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"500\" \/>\n\t<meta property=\"og:image:height\" content=\"230\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta 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