{"id":22963,"date":"2016-05-19T13:12:39","date_gmt":"2016-05-19T13:12:39","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=22963"},"modified":"2016-05-23T07:57:37","modified_gmt":"2016-05-23T07:57:37","slug":"investigadores-generan-injertos-de-corazon-funcionales-a-partir-de-celulas-madre-pluripotentes-humanas","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/es\/investigadores-generan-injertos-de-corazon-funcionales-a-partir-de-celulas-madre-pluripotentes-humanas\/","title":{"rendered":"Investigadores generan injertos de coraz\u00f3n funcionales a partir de c\u00e9lulas madre pluripotentes humanas"},"content":{"rendered":"
Imagen: Diferenciaci\u00f3n card\u00edaca de c\u00e9lulas madre pluripotentes humanas derivadas a cardiomiocitos en la matriz extracelular de un ventr\u00edculo descelurarizado<\/h6>\n

Las c\u00e9lulas dentro de la matriz descelularizada de coraz\u00f3n humano mostraron un mayor grado de diferenciaci\u00f3n card\u00edaca fisiol\u00f3gica y molecular en comparaci\u00f3n con las c\u00e9lulas cultivadas en placas de cultivo de tejido, que ha sido el m\u00e9todo utilizado hasta ahora. En solo 24 d\u00edas los injertos card\u00edacos humanos ya presentaban las respuestas electrofisiol\u00f3gicas necesarias para desarrollar una funci\u00f3n card\u00edaca correcta, es decir, bombeaban de un modo similar al del coraz\u00f3n. <\/p>\n

\"Imagen:<\/a>
Cardiomyocyte-like cells derived from human pluripotent stem cells<\/figcaption><\/figure>\n

Este tipo de des- y recelularizaci\u00f3n de \u00f3rganos representa una estrategia prometedora para el desarrollo de \u00f3rganos biofuncionales que se pueden ser utilizados para la detecci\u00f3n de drogas y el desarrollo de la medicina personalizada.<\/p>\n

\u00abLa descelularizaci\u00f3n de todo un coraz\u00f3n implica cientos de secciones acelulares listas para utilizarse como andamios\u00bb, dice Nuria Montserrat desde el IBEC, una de los tres autores principales del art\u00edculo cient\u00edfico. \u00abAnticipamos que nuestro procedimiento r\u00e1pido puede ser aplicado de inmediato en los laboratorios para la ingenier\u00eda card\u00edaca y el modelado de enfermedades aplicado a los seres humanos.\u00bb<\/p>\n

El estudio en el que han participado investigadores de IBEC y del Hospital General Universitario Gregorio Mara\u00f1\u00f3n de Espa\u00f1a, as\u00ed como la Universidad de Minesota, el Texas Heart Institute y el Salk Institute for Biological Studies en los EE.UU., fue financiado en parte por una subvenci\u00f3n European Research Council. <\/p>\n

—<\/p>\n

Art\u00edculo de referencia:<\/em> <\/strong>Elena Garreta, Lorena de O\u00f1ate, M. Eugenia Fern\u00e1ndez-Santos, Roger Oria, Carolina Tarantino, Andreu M. Climent, Andr\u00e9s Marco, Mireia Samitier, Elena Mart\u00ednez, Maria Valls-Margarit, Rafael Matesanz, Doris A. Taylor, Francisco Fern\u00e1ndez-Avil\u00e9s, Juan Carlos Izpisua Belmonte & Nuria Montserrat (2016). Myocardial commitment from human pluripotent stem cells: Rapid production of human heart grafts.<\/a> Biomaterials<\/em>, 98, 64-78<\/p>\n

—<\/p>\n

IBEC in the media:<\/strong><\/em>
\nLa Vanguardia, \u00abCrean injertos de coraz\u00f3n a partir de c\u00e9lulas madre en menos de un mes\u00bb<\/a>
\nLa Raz\u00f3n, \u00abCrean injertos de coraz\u00f3n con c\u00e9lulas madre\u00bb<\/a>
\nDiario M\u00e9dico, \u00abCrean injertos de coraz\u00f3n a partir de c\u00e9lulas madre\u00bb
\n<\/a>Agencia SINC, \u00abInjertos de coraz\u00f3n funcionales a partir de c\u00e9lulas madre pluripotentes humanas\u00bb<\/a>
\nHuelva Informaci\u00f3n, \u00abInjertos de coraz\u00f3n funcionales a partir de c\u00e9lulas madre\u00bb<\/a>
\nEl D\u00eda de C\u00f3rdoba,\u00a0\u00abInjertos de coraz\u00f3n funcionales a partir de c\u00e9lulas madre\u00bb<\/a>
\nM\u00e1laga Hoy,\u00a0\u00abInjertos de coraz\u00f3n funcionales a partir de c\u00e9lulas madre\u00bb<\/a>
\nDiario de C\u00e1diz,\u00a0\u00abInjertos de coraz\u00f3n funcionales a partir de c\u00e9lulas madre\u00bb<\/a>
\nDiaro de Sevilla,\u00a0\u00abInjertos de coraz\u00f3n funcionales a partir de c\u00e9lulas madre\u00bb<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

\"Foto2\"Investigadores del Instituto de Bioingenier\u00eda de Catalu\u00f1a (IBEC), en colaboraci\u00f3n con el Hospital General Universitario Gregorio Mara\u00f1\u00f3n y dos grupos de los EE.UU. han creado, por primera vez, injertos de coraz\u00f3n a partir de c\u00e9lulas madre pluripotentes humanas en un per\u00edodo inferior a un mes.<\/h3>\n

El estudio, publicado recientemente en la revista Biomaterials, describe c\u00f3mo los investigadores han descelularizado corazones humanos calificados como \u00abno aptos para el trasplante\u00bb por la Organizaci\u00f3n Nacional de Trasplantes, dejando la matriz extracelular intacta y libre de c\u00e9lulas, y a continuaci\u00f3n, la han repoblado con c\u00e9lulas card\u00edacas obtenidas a partir de t\u00e9cnicas de edici\u00f3n del genoma en c\u00e9lulas madres pluripotentes humanas (hPSCs) (c\u00e9lulas no diferenciadas, a partir de las cuales se pueden desarrollar otros tipos celulares). Las c\u00e9lulas madre pluripotentes son cruciales para este proceso, ya que el cuerpo no es capaz de generar nuevas c\u00e9lulas card\u00edacas tras un ataque al coraz\u00f3n u otro tipo de da\u00f1o card\u00edaco.<\/p>\n","protected":false},"author":4,"featured_media":22879,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[97],"tags":[],"post_formats":[],"class_list":["post-22963","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias-de-investigacion"],"yoast_head":"\nInvestigadores generan injertos de coraz\u00f3n funcionales a partir de c\u00e9lulas madre pluripotentes humanas - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/es\/investigadores-generan-injertos-de-corazon-funcionales-a-partir-de-celulas-madre-pluripotentes-humanas\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Investigadores generan injertos de coraz\u00f3n funcionales a partir de c\u00e9lulas madre pluripotentes humanas - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Investigadores del Instituto de Bioingenier\u00eda de Catalu\u00f1a (IBEC), en colaboraci\u00f3n con el Hospital General Universitario Gregorio Mara\u00f1\u00f3n y dos grupos de los EE.UU. han creado, por primera vez, injertos de coraz\u00f3n a partir de c\u00e9lulas madre pluripotentes humanas en un per\u00edodo inferior a un mes. 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