{"id":27279,"date":"2017-01-31T09:07:19","date_gmt":"2017-01-31T08:07:19","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=27279"},"modified":"2017-01-31T12:07:01","modified_gmt":"2017-01-31T11:07:01","slug":"light-regulated-drugs-as-analgesics","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/es\/light-regulated-drugs-as-analgesics\/","title":{"rendered":"Mol\u00e9culas reguladas con luz para aliviar s\u00edntomas del dolor cr\u00f3nico"},"content":{"rendered":"<p class=\"p1\">su origen, que puede ser tanto fisiol\u00f3gico como emocional, y va acompa\u00f1ado de s\u00edntomas como hipersensibilidad al dolor, ansiedad y comportamiento depresivo. No tiene cura, su tratamiento es dif\u00edcil y los f\u00e1rmacos actuales no consiguen aliviar los s\u00edntomas.<\/p>\n<p class=\"p1\"><span class=\"s1\">En el trabajo\u00a0publicado en la revista <i>ACS Central Science<\/i>, el grupo de Nanosondas y Nanoconmuntadores del IBEC junto con sus colaboradores,\u00a0obtuvieron\u00a0una serie de fenilazopiridinas, mol\u00e9culas que act\u00faan sobre el receptor mGlu5, uno de los dos receptores cerebrales relacionados con las emociones asociadas a dolor cr\u00f3nico, como la ansiedad.<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">Los ensayos, realizados sobre c\u00e9lulas y sobre larvas de peces cebra, demuestran que la administraci\u00f3n localizada de luz y de las fenilazopiridinas fotoconmutables tiene efectos sobre la actividad de los receptores mGlu. Este\u00a0 efecto depende de la iluminaci\u00f3n, lo que demuestra, explican los cient\u00edficos, que se puede regular con luz la actividad biol\u00f3gica de las mol\u00e9culas sobre el receptor mGlu5. Adem\u00e1s, el trabajo tambi\u00e9n\u00a0 demuestra que la acci\u00f3n de la luz y mol\u00e9culas fotoconmutables en tejidos localizados, incluyendo el cerebro en ratones vivos, puede regular su efecto analg\u00e9sico.<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">\u00abLos resultados, todav\u00eda en\u00a0etapa preliminar, demuestran las posibilidades de desarrollo futuro de terapias basadas en la fotofarmacolog\u00eda\u00bb, dice Pau Gorostiza, profesor ICREA\u00a0y responsable de grupo en el IBEC.<\/span><\/p>\n<p>&#8212;<\/p>\n<p><strong>Art\u00edculo referenciado:<\/strong><br \/>\nXavier G\u00f3mez-Santacana, Silvia Pittolo, Xavier Rovira, Marc Lopez, Charleine Zussy, James A. R. Dalton, Ad\u00e8le Faucherre, Chris Jopling, Jean-Philippe Pin, Francisco Ciruela, Cyril Goudet, Jes\u00fas Giraldo, Pau Gorostiza, and Amadeu Llebaria. (2017). <a href=\"http:\/\/pubs.acs.org\/doi\/abs\/10.1021\/acscentsci.6b00353\" target=\"_blank\">Illuminating Phenylazopyridines To Photoswitch Metabotropic Glutamate Receptors: From the Flask to the Animals.<\/a> <em>ACS Central Science<\/em> DOI: 10.1021\/acscentsci.6b00353<\/p>\n<p>&#8212;<br \/>\n<strong>IBEC en los Medios:<\/strong>\u00a0Este fin de semana, Pau Gorostiza fue <a href=\"http:\/\/mvod.lvlt.rtve.es\/resources\/TE_SDLMNAT\/mp3\/9\/2\/1485648553129.mp3\">entrevistado en la Radio Nacional de Espa\u00f1a (RNE)<\/a>\u00a0\u00a0con motivo de este estudio. \u00a0Puedes escucharlo haciendo clic sobre el enlace, su parte comienza en el minuto\u00a033\u201d.<\/p>\n","protected":false},"excerpt":{"rendered":"<h3><img decoding=\"async\" class=\"left size-full wp-image-27328 lazyload\" data-src=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2017\/01\/pauacscentral.jpg\" alt=\"\" width=\"500\" height=\"175\" data-srcset=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2017\/01\/pauacscentral.jpg 500w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2017\/01\/pauacscentral-300x105.jpg 300w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2017\/01\/pauacscentral-230x81.jpg 230w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2017\/01\/pauacscentral-150x53.jpg 150w\" data-sizes=\"(max-width: 500px) 100vw, 500px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 500px; --smush-placeholder-aspect-ratio: 500\/175;\" \/>Un nuevo estudio, en el que est\u00e1n involucrados investigadores del IBEC, IQAC\/CSIC y CNRS en Francia, halla nuevas dianas terap\u00e9uticas para aliviar, mediante mol\u00e9culas reguladas con luz, s\u00edntomas y emociones negativas asociados al dolor cr\u00f3nico, como la ansiedad y el miedo. <\/h3>\n<p>El dolor cr\u00f3nico es aquel que no responde a una causa puntual en el tiempo y se prolonga m\u00e1s all\u00e1 de seis meses o, incluso, a\u00f1os. A veces es dif\u00edcil determinar <\/p>\n","protected":false},"author":4,"featured_media":27332,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[97],"tags":[],"post_formats":[],"class_list":["post-27279","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias-de-investigacion"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Mol\u00e9culas reguladas con luz para aliviar s\u00edntomas del dolor cr\u00f3nico - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/es\/light-regulated-drugs-as-analgesics\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Mol\u00e9culas reguladas con luz para aliviar s\u00edntomas del dolor cr\u00f3nico - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Un nuevo estudio, en el que est\u00e1n involucrados investigadores del IBEC, IQAC\/CSIC y CNRS en Francia, halla nuevas dianas terap\u00e9uticas para aliviar, mediante mol\u00e9culas reguladas con luz, s\u00edntomas y emociones negativas asociados al dolor cr\u00f3nico, como la ansiedad y el miedo.  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