{"id":27829,"date":"2017-02-28T09:34:04","date_gmt":"2017-02-28T08:34:04","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/es\/a-new-therapeutic-target-that-could-slow-the-progression-of-parkinsons-disease\/"},"modified":"2017-03-02T14:46:49","modified_gmt":"2017-03-02T13:46:49","slug":"a-new-therapeutic-target-that-could-slow-the-progression-of-parkinsons-disease","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/es\/a-new-therapeutic-target-that-could-slow-the-progression-of-parkinsons-disease\/","title":{"rendered":"Encuentran una nueva diana terap\u00e9utica que podr\u00eda frenar el avance del Parkinson"},"content":{"rendered":"
a) Dispositivo microflu\u00eddico empleado en el estudio. Se pueden observar neuronas corticales primarias despu\u00e9s de 15 d\u00edas de cultivo in vitro. b) Immunolocalizaci\u00f3n de la versi\u00f3n maligna de la \u03b1-sinucle\u00edna (verde) en el dispositivo microflu\u00eddico despu\u00e9s de la inoculaci\u00f3n con la \u03b1-sinucle\u00edna recombinante. c) Fotomicrograf\u00eda mostrando ejemplos de neuronas corticales adultas con un contenido significativo de sinucle\u00edna degenerada 45 d\u00edas despu\u00e9s de la inyecci\u00f3n de la \u03b1-sinucle\u00edna en el estriado.<\/h6>\n

En su estudio, publicado esta semana, los investigadores revelan que, adem\u00e1s de llevar a cabo esas funciones, la PrPc<\/sup> tambi\u00e9n se une a una forma pat\u00f3gena de la \u03b1-sinucle\u00edna y fomenta su propagaci\u00f3n entre neuronas. Esta prote\u00edna, cuando est\u00e1 fosforilada – o lo que es lo mismo, en su su forma maligna -, causa la degeneraci\u00f3n y muerte neuronal en enfermedades como el Parkinson. El resultado de los investigadores apunta a la PrPc<\/sup> como una posible diana terap\u00e9utica para frenar el avance en este tipo de patolog\u00edas<\/p>\n

Este avance cient\u00edfico, fruto de la colaboraci\u00f3n entre tres grupos del IBEC , as\u00ed como de investigadores del Tokyo Metropolitan Institute of Medical Science, el Hospital de Bellvitge y el Instituto de Investigaci\u00f3n de la Vall d\u2019Hebron en Barcelona, y el Instituto de Investigaci\u00f3n en Ingenier\u00eda de Arag\u00f3n en la Universidad de Zaragoza, podr\u00eda ser relevante en otras patolog\u00edas neurodegenerativas, incluyendo algunos tipos de demencia, el Alzheimer o la atrofia multisist\u00e9mica.<\/p>\n

El Parkinson es una enfermedad neurodegenerativa que afecta al movimiento. Se origina cuando un tipo particular de neuronas se degeneran y mueren, afectando a las funciones motoras y cognitivas del sistema nervioso central. Los responsables de esta degeneraci\u00f3n son los cuerpos de Lewy, unos agregados an\u00f3malos que se forman en el interior de las neuronas a base de una versi\u00f3n maligna de la \u03b1-sinucle\u00edna, una prote\u00edna que abunda en el citoplasma de las neuronas. Cuando la \u03b1-sinucle\u00edna no se puede degradar correctamente, su forma cambia, la prote\u00edna se fosforila y empieza a aglomerarse, creando estos cuerpos de Lewy densos e insolubles.<\/p>\n

Estos agregados proliferan en el interior de la neurona y despiertan su respuesta autoinmune, que termina causando el suicidio de la propia c\u00e9lula. El proceso es r\u00e1pido y devastador, dado que la forma pat\u00f3gena de la \u03b1-sinucle\u00edna es capaz de propagarse a trav\u00e9s de las conexiones entre neuronas, cruzando diferentes regiones del cerebro y formando nuevos cuerpos de Lewy a su paso, lo cual causa un da\u00f1o irreversible en un n\u00famero creciente de c\u00e9lulas a lo largo del tiempo.<\/p>\n

Los investigadores del IBEC y sus colaboradores han observado que la sobreexpresi\u00f3n de la PrPc<\/sup> en la membrana neuronal incrementa la uni\u00f3n y expansi\u00f3n de la \u03b1-sinucle\u00edna pat\u00f3gena entre neuronas y, m\u00e1s tarde, la formaci\u00f3n de los cuerpos de Lewy. \u201cHemos visto claramente como la \u03b1-sinucle\u00edna es capaz de viajar de una regi\u00f3n cerebral a otras, dejando a su paso un n\u00famero muy alto de neuronas muertas y otras moribundas\u201d dice Laura Urrea, primera autora del estudio.<\/p>\n

\u201cLa PrPc<\/sup> es una pieza clave para la propagaci\u00f3n de los cuerpos de Lewy\u201d, a\u00f1ade Jos\u00e9 Antonio Del R\u00edo, coordinador del estudio e investigador principal del\u00a0grupo Neurobiolog\u00eda Molecular y Celular<\/a> del IBEC\u00a0y profesor en la\u00a0Universidad de Barcelona\u00a0(UB) . \u201cSi pudi\u00e9ramos evitar que estas acumulaciones maliciosas se formaran y propagaran, podr\u00edamos detener la progresi\u00f3n de la muerte neuronal en enfermedades como el Parkinson\u201d.<\/p>\n

Adem\u00e1s de sus experimentos in vivo <\/em>e in vitro<\/em>, el equipo de Del R\u00edo ha desarrollado un dispositivo microflu\u00eddico capaz de distinguir la interacci\u00f3n espec\u00edfica entre la PrPc<\/sup> y la \u03b1-sinucle\u00edna que facilita su transporte entre neuronas. \u201cA d\u00eda de hoy, hemos identificado un dominio en la PrPc<\/sup> que podr\u00eda ser la diana terap\u00e9utica clave para contener en transporte de la \u03b1-sinucle\u00edna entre neuronas y as\u00ed frenar el avance de la enfermedad\u201d, a\u00f1ade el investigador.<\/p>\n

Este estudio, en el que tambi\u00e9n han participado los grupos de\u00a0Nanobioingenier\u00eda<\/a> y Infecciones Bacterianas: terapias antimicrobianas<\/a>\u00a0del IBEC -liderados respectivamente por Josep Samitier y Eduard Torrents, ambos profesores en la Universidad de Barcelona (UB)-,\u00a0ha sido posible gracias a la financiaci\u00f3n de La Marat\u00f3 de TV3<\/a>, el MINECO<\/a> y el Centro de Investigaci\u00f3n Biom\u00e9dica en Red sobre Enfermedades Neurodegenerativas (CIBERNED<\/a>), entre otros.<\/p>\n

—<\/p>\n

Article:<\/strong> <\/em>Urrea L, Segura-Feliu M, Masuda-Suzukake M, Hervera A, Pedraz L, Aznar JM, Vila M, Samitier J, Torrents E, Ferrer I, Gav\u00edn R, Hagesawa M, Del R\u00edo JA. (2017). Involvement of Cellular Prion Protein in \u03b1-Synuclein Transport in Neurons.<\/a> Mol Neurobiol.<\/em>, epub ahead of print<\/p>\n","protected":false},"excerpt":{"rendered":"

\"\"Investigadores del IBEC han identificado un posible mecanismo para frenar la progresi\u00f3n neurodegenerativa de la enfermedad de Parkinson.
\n <\/h3>\n

La clave del estudio se encuentra en la prote\u00edna pri\u00f3nica celular (PrPc<\/sup>), una mol\u00e9cula especializada que se encuentra en la membrana de las neuronas y que participa en muchas de sus funciones, como el control del ciclo celular y la neurotransmisi\u00f3n.<\/p>\n","protected":false},"author":4,"featured_media":27819,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[97],"tags":[],"post_formats":[],"class_list":["post-27829","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias-de-investigacion"],"yoast_head":"\nEncuentran una nueva diana terap\u00e9utica que podr\u00eda frenar el avance del Parkinson - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/es\/a-new-therapeutic-target-that-could-slow-the-progression-of-parkinsons-disease\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Encuentran una nueva diana terap\u00e9utica que podr\u00eda frenar el avance del Parkinson - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Investigadores del IBEC han identificado un posible mecanismo para frenar la progresi\u00f3n neurodegenerativa de la enfermedad de Parkinson. 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