{"id":29968,"date":"2017-06-20T09:42:50","date_gmt":"2017-06-20T07:42:50","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/es\/?p=29968"},"modified":"2017-06-26T13:04:02","modified_gmt":"2017-06-26T11:04:02","slug":"el-ibec-a-la-vanguardia-de-la-investigacion-en-mecanobiologia","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/es\/el-ibec-a-la-vanguardia-de-la-investigacion-en-mecanobiologia\/","title":{"rendered":"El IBEC a la vanguardia de la investigaci\u00f3n en mecanobiolog\u00eda"},"content":{"rendered":"
La imagen muestra dos t\u00e9cnicas de biolog\u00eda celular para cuantificar las fuerzas celulares en escalas diferentes: Arriba, mapas de tracci\u00f3n y estr\u00e9s de microscop\u00eda de tracci\u00f3n durante la migraci\u00f3n colectiva de una monocapa de c\u00e9lulas epiteliales. En la parte inferior, la fuerza que ejerce una \u00fanica fibra de actina del citoesqueleto celular se examina mediante la ablaci\u00f3n l\u00e1ser. <\/h6>\n

Durante las \u00faltimas dos d\u00e9cadas, los avances en nuestra comprensi\u00f3n de estos mecanismos han permitido a los investigadores averiguar m\u00e1s sobre las fuerzas generadas por las c\u00e9lulas en diferentes escalas, que van desde las fuerzas moleculares – c\u00f3mo se pliega el dominio de una prote\u00edna \u2013 a patrones de fuerza supra-celulares de largo alcance tales como los que rigen la cicatrizaci\u00f3n de heridas o la migraci\u00f3n colectiva de las c\u00e9lulas .<\/p>\n

Las nuevas herramientas y t\u00e9cnicas – que incluyen tipos especializados de microscop\u00eda o ablaci\u00f3n l\u00e1ser – han permitido a los cient\u00edficos descubrir el papel de las fuerzas en la c\u00e9lula y han redefinido aspectos fundamentales de la biolog\u00eda celular y la mecanobiolog\u00eda en particular. Hace solo unos a\u00f1os ve\u00edamos las fuerzas celulares como meros interruptores de la mecanotransducci\u00f3n, proceso a trav\u00e9s del cual las c\u00e9lulas detectan y responden a los est\u00edmulos mec\u00e1nicos convirti\u00e9ndolos en se\u00f1ales bioqu\u00edmicas. En cambio ahora sabemos que estas fuerzas pueden difundir y transferir informaci\u00f3n, no s\u00f3lo dentro de c\u00e9lulas individuales, sino tambi\u00e9n a trav\u00e9s de tejidos enteros. Esta nueva concepci\u00f3n de las fuerzas celulares es un gran paso hacia una comprensi\u00f3n completa de la funci\u00f3n celular en el organismo.<\/p>\n

Nature Cell Biology<\/em> public\u00f3 en febrero otro trabajo del profesor ICREA Xavier Trepat, tambi\u00e9n profesor asociado de la Universidad de Barcelona, con un art\u00edculo sobre las fuerzas f\u00edsicas en la invasi\u00f3n metast\u00e1tica del c\u00e1ncer<\/a>.<\/p>\n

—<\/p>\n

Pere Roca-Cusachs, Vito Conte and Xavier Trepat (2017). Quantifying forces in cell biology<\/a>. Nature Cell Biology<\/em>, 19, 7<\/p>\n","protected":false},"excerpt":{"rendered":"

\"\"Hoy tres investigadores principales del IBEC – Pere Roca-Cusachs, Vito Conte y Xavier Trepat – consolidan el liderazgo del instituto en mecanobiolog\u00eda publicando un art\u00edculo de revisi\u00f3n en Nature Cell Biology<\/em>.<\/h3>\n

El art\u00edculo, \u201cQuantifying forces in cell biology\u201d<\/em>, hace un resumen de una amplia gama de sensores y m\u00e9todos de detecci\u00f3n capaces de cuantificar las fuerzas generadas por las c\u00e9lulas.<\/p>\n","protected":false},"author":4,"featured_media":29919,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[97],"tags":[],"post_formats":[],"class_list":["post-29968","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias-de-investigacion"],"yoast_head":"\nEl IBEC a la vanguardia de la investigaci\u00f3n en mecanobiolog\u00eda - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/es\/el-ibec-a-la-vanguardia-de-la-investigacion-en-mecanobiologia\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"El IBEC a la vanguardia de la investigaci\u00f3n en mecanobiolog\u00eda - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Hoy tres investigadores principales del IBEC - Pere Roca-Cusachs, Vito Conte y Xavier Trepat - consolidan el liderazgo del instituto en mecanobiolog\u00eda publicando un art\u00edculo de revisi\u00f3n en Nature Cell Biology. 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