{"id":38283,"date":"2017-10-13T11:30:17","date_gmt":"2017-10-13T09:30:17","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=38283"},"modified":"2017-10-24T10:14:42","modified_gmt":"2017-10-24T08:14:42","slug":"micronadadores-usan-bacterias-sanas-para-atacara-las-biopeliculas-daninas","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/es\/micronadadores-usan-bacterias-sanas-para-atacara-las-biopeliculas-daninas\/","title":{"rendered":"Micronadadores usan bacterias ‘sanas’ para atacara las biopel\u00edculas da\u00f1inas"},"content":{"rendered":"
Arriba a la izquierda: c\u00e9lulas MSR-1 capturadas dentro de un microtubo; arriba a la derecha: bioh\u00edbrido atrapado en una biopel\u00edcula de E. coli.<\/h6>\n

Las colonias que proliferan en las biopel\u00edculas generalmente son resistentes a los antibi\u00f3ticos y requieren de m\u00e9todos espec\u00edficos de eliminaci\u00f3n. Uno de estos m\u00e9todos utiliza nanopart\u00edculas como portadores para la administraci\u00f3n de antibi\u00f3ticos, que circulan de forma aleatoria en l\u00edquido hasta que entran en contacto con las \u00e1reas infectadas. Sin embargo, estos no son muy efectivos, ya que necesitan poder acercarse mucho a la biopel\u00edcula.<\/p>\n

En el art\u00edculo publicado en ACS Nano<\/em>, el grupo y sus colaboradores del Max Planck Institute for Intelligent Systems<\/em> de Stuttgart demuestran que las bacterias no pat\u00f3genas Magnetosopirrillum gryphiswalense<\/em> (MSR-1) pueden integrarse con los microtubos cargados de f\u00e1rmaco para construir sistemas bioh\u00edbridos controlables o ‘micronadadores’ capaces de administrar antibi\u00f3ticos para combatir una biopel\u00edcula infecciosa.<\/p>\n

\u00abAplicando la capacidad de orientaci\u00f3n magn\u00e9tica externa y el potencial de las c\u00e9lulas MSR-1 como nadadores, nuestros bioh\u00edbridos pueden ser dirigidos e introducidos en biopel\u00edculas maduras de E. coli<\/em>\u00ab, explica el Profesor ICREA e investigador principal del IBEC, Samuel S\u00e1nchez. \u00abLa liberaci\u00f3n del antibi\u00f3tico, ciprofloxacina, es desencadenada por el microambiente \u00e1cido de la biopel\u00edcula\u00bb.<\/p>\n

Al revisar las biopel\u00edculas que trataron con sus bioh\u00edbridos despu\u00e9s de 24 horas y de 48 horas respectivamente, los investigadores vieron que las biopel\u00edculas no volv\u00edan a formarse. \u00abNuestros bioh\u00edbridos penetran profundamente en las capas e impiden la progresi\u00f3n de la biopel\u00edcula\u00bb, afirma Samuel.<\/p>\n

La capacidad de las bacterias no pat\u00f3genas para dirigirse y desmantelar biopel\u00edculas da\u00f1inas abre las puertas a su uso para sistemas bioh\u00edbridos en aplicaciones anti-biopel\u00edcula en el futuro.<\/p>\n

—<\/p>\n

Art\u00edculo referenciado:<\/strong> <\/em>Morgan M. Stanton, Byung-Wook Park, Diana Vilela, Klaas Bente, Damien Faivre, Metin Sitti, and Samuel S\u00e1nchez (2017). Magnetotactic Bacteria Powered Biohybrids Target E. coli Biofilms.<\/a> ACS Nano<\/em>, 10.1021\/acsnano.7b04128<\/p>\n","protected":false},"excerpt":{"rendered":"

\"\" El \u00faltimo art\u00edculo del grupo Smart nano-bio-devices<\/em> del IBEC aborda el problema de las biopel\u00edculas, las \u00abciudades de microbios\u00bb que facilitan la comunicaci\u00f3n de c\u00e9lula a c\u00e9lula entre las bacterias, permitiendo que la infecci\u00f3n prospere y aumentando las posibilidades de evadir el sistema inmune. En el cuerpo, estas biopel\u00edculas se pueden encontrar en una amplia variedad de infecciones microbianas, como en los pulmones de los pacientes con fibrosis qu\u00edstica o en la enfermedad pulmonar obstructiva cr\u00f3nica (EPOC). <\/h3>\n","protected":false},"author":4,"featured_media":38284,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[97],"tags":[],"post_formats":[],"class_list":["post-38283","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias-de-investigacion"],"yoast_head":"\nMicronadadores usan bacterias 'sanas' para atacara las biopel\u00edculas da\u00f1inas - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/es\/micronadadores-usan-bacterias-sanas-para-atacara-las-biopeliculas-daninas\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Micronadadores usan bacterias 'sanas' para atacara las biopel\u00edculas da\u00f1inas - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"El \u00faltimo art\u00edculo del grupo Smart nano-bio-devices del IBEC aborda el problema de las biopel\u00edculas, las "ciudades de microbios" que facilitan la comunicaci\u00f3n de c\u00e9lula a c\u00e9lula entre las bacterias, permitiendo que la infecci\u00f3n prospere y aumentando las posibilidades de evadir el sistema inmune. En el cuerpo, estas biopel\u00edculas se pueden encontrar en una amplia variedad de infecciones microbianas, como en los pulmones de los pacientes con fibrosis qu\u00edstica o en la enfermedad pulmonar obstructiva cr\u00f3nica (EPOC).\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ibecbarcelona.eu\/es\/micronadadores-usan-bacterias-sanas-para-atacara-las-biopeliculas-daninas\/\" \/>\n<meta property=\"og:site_name\" content=\"Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"article:published_time\" content=\"2017-10-13T09:30:17+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2017-10-24T08:14:42+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2017\/10\/fish.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"450\" \/>\n\t<meta property=\"og:image:height\" content=\"406\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"\u00c0ngels L\u00f3pez\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"\u00c0ngels L\u00f3pez\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/micronadadores-usan-bacterias-sanas-para-atacara-las-biopeliculas-daninas\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/micronadadores-usan-bacterias-sanas-para-atacara-las-biopeliculas-daninas\\\/\"},\"author\":{\"name\":\"\u00c0ngels L\u00f3pez\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/person\\\/c212c6b589546130be67986b9290e2b8\"},\"headline\":\"Micronadadores usan bacterias ‘sanas’ para atacara las biopel\u00edculas da\u00f1inas\",\"datePublished\":\"2017-10-13T09:30:17+00:00\",\"dateModified\":\"2017-10-24T08:14:42+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/micronadadores-usan-bacterias-sanas-para-atacara-las-biopeliculas-daninas\\\/\"},\"wordCount\":352,\"publisher\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/micronadadores-usan-bacterias-sanas-para-atacara-las-biopeliculas-daninas\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2017\\\/10\\\/fish.jpg\",\"articleSection\":[\"Noticias de investigaci\u00f3n\"],\"inLanguage\":\"es\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/micronadadores-usan-bacterias-sanas-para-atacara-las-biopeliculas-daninas\\\/\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/micronadadores-usan-bacterias-sanas-para-atacara-las-biopeliculas-daninas\\\/\",\"name\":\"Micronadadores usan bacterias 'sanas' para atacara las biopel\u00edculas da\u00f1inas - 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