{"id":56679,"date":"2017-11-30T17:04:47","date_gmt":"2017-11-30T16:04:47","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=56679"},"modified":"2017-12-01T11:42:05","modified_gmt":"2017-12-01T10:42:05","slug":"investigadores-del-ibec-disenan-un-contacto-electrico-con-una-sola-proteina","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/es\/investigadores-del-ibec-disenan-un-contacto-electrico-con-una-sola-proteina\/","title":{"rendered":"Investigadores del IBEC dise\u00f1an un contacto el\u00e9ctrico con una sola prote\u00edna"},"content":{"rendered":"<h6 class=\"caption\" style=\"float: left; padding: 0px 30px 10px 0px;\">Transferencia de electrones en la proteina azurina sin la mutaci\u00f3n (izquierda, transporte en dos pasos) y despu\u00e9s de la mutaci\u00f3n puntual (derecha, transporte por efecto t\u00fanel).<\/h6>\n<p>La bioelectr\u00f3nica avanza hacia el dise\u00f1o de plataformas electr\u00f3nicas en la nanoescala, que permitan conectar biomol\u00e9culas complejas a dispositivos electr\u00f3nicos para la transducci\u00f3n de se\u00f1ales. El acercamiento a estas tecnolog\u00edas debe ser de \u201cabajo-a-arriba\u201d: necesitamos entender la firma el\u00e9ctrica de las biomol\u00e9culas m\u00e1s simples para crear despu\u00e9s circuitos m\u00e1s complejos o entender estructuras macromoleculares.  <\/p>\n<p>Con este objetivo, el <a href=\"https:\/\/ibecbarcelona.eu\/nanoprobes\" target=\"_blank\" rel=\"noopener\">grupo del investigador principal del IBEC y profesor de investigaci\u00f3n ICREA Pau Gorostiza<\/a> ha desarrollado un contacto el\u00e9ctrico de una sola prote\u00edna capaz de transportar carga el\u00e9ctrica de forma eficiente. Los resultados revelan que una sola mutaci\u00f3n puntual en la Azurina, la biomol\u00e9cula empleada en el estudio, promueve un eficiente efecto t\u00fanel a los electrones que la atraviesan. \u201cLa Azurina tiene un \u00e1tomo de cobre; normalmente, el transporte electr\u00f3nico mediado por este metal sucede en dos pasos para cada electr\u00f3n; con una sola mutaci\u00f3n, nosotros hemos conseguido que el transporte electr\u00f3nico siga un efecto t\u00fanel directo\u201d, explica Marta Pozuelo, recientemente doctorada en el grupo de Pau y que ha desarrollado el estudio. <\/p>\n<p>Los resultados demuestran que las v\u00edas de conducci\u00f3n el\u00e9ctrica de la Azurina se pueden ajustar con mucha precisi\u00f3n por medio de mutaciones puntuales en la parte externa de la prote\u00edna, sin afectar a su estructura y funci\u00f3n global. \u201cHemos demostrado un mecanismo estructural mediante el cual la prote\u00edna podr\u00eda controlar el transporte de carga en muchos escenarios de inter\u00e9s biol\u00f3gico\u201d, sugiere Pau. <\/p>\n<p>Este contacto nanom\u00e9trico supone adem\u00e1s una plataforma \u00fanica para estudiar los cambios en la transferencia de electrones relacionados con la estructura de diversas biomol\u00e9culas similares a la azurina.<\/p>\n<p>&#8212;<\/p>\n<p><strong>Art\u00edculo referenciado:<\/strong> Ruiz MP, Aragon\u00e8s AC, Camarero N, Vilhena JG, Ortega M, Zotti LA, P\u00e9rez R, Cuevas JC, Gorostiza P, D\u00edez-P\u00e9rez I. (2017). <a href=\"http:\/\/pubs.acs.org\/doi\/abs\/10.1021\/jacs.7b06130\" target=\"_blank\" rel=\"noopener\">Bioengineering a Single-Protein Junction<\/a>. <em>J Am Chem Soc.<\/em> 139(43):15337-15346<\/p>\n","protected":false},"excerpt":{"rendered":"<h3><a href=\"https:\/\/ibecbarcelona.eu\/azurinjacs\/\"><img decoding=\"async\" class=\"left size-full wp-image-56660 lazyload\" data-src=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2017\/11\/azurinJACS.jpg\" alt=\"\" width=\"400\" height=\"209\" data-srcset=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2017\/11\/azurinJACS.jpg 400w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2017\/11\/azurinJACS-300x157.jpg 300w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2017\/11\/azurinJACS-230x120.jpg 230w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2017\/11\/azurinJACS-150x78.jpg 150w\" data-sizes=\"(max-width: 400px) 100vw, 400px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 400px; --smush-placeholder-aspect-ratio: 400\/209;\" \/><\/a>El grupo del IBEC Nanoprobes and Nanoswitches ha dise\u00f1ado un contacto el\u00e9ctrico nanom\u00e9trico basado en una \u00fanica prote\u00edna. <\/h3>\n<p>A trav\u00e9s de una sutil mutaci\u00f3n en la prote\u00edna Azurina, responsable de diversos procesos metab\u00f3licos REDOX en la bacteria <em>Pseudomona Aeruginosa<\/em>, han conseguido controlar el transporte de electrones en la biomol\u00e9cula.   <\/p>\n","protected":false},"author":4,"featured_media":56660,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[97],"tags":[],"post_formats":[],"class_list":["post-56679","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias-de-investigacion"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Investigadores del IBEC dise\u00f1an un contacto el\u00e9ctrico con una sola prote\u00edna - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/es\/investigadores-del-ibec-disenan-un-contacto-electrico-con-una-sola-proteina\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Investigadores del IBEC dise\u00f1an un contacto el\u00e9ctrico con una sola prote\u00edna - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"El grupo del IBEC Nanoprobes and Nanoswitches ha dise\u00f1ado un contacto el\u00e9ctrico nanom\u00e9trico basado en una \u00fanica prote\u00edna.   A trav\u00e9s de una sutil mutaci\u00f3n en la prote\u00edna Azurina, responsable de diversos procesos metab\u00f3licos REDOX en la bacteria Pseudomona Aeruginosa, han conseguido controlar el transporte de electrones en la biomol\u00e9cula.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ibecbarcelona.eu\/es\/investigadores-del-ibec-disenan-un-contacto-electrico-con-una-sola-proteina\/\" \/>\n<meta property=\"og:site_name\" content=\"Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"article:published_time\" content=\"2017-11-30T16:04:47+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2017-12-01T10:42:05+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2017\/11\/azurinJACS.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"400\" \/>\n\t<meta property=\"og:image:height\" content=\"209\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"\u00c0ngels L\u00f3pez\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"\u00c0ngels L\u00f3pez\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/investigadores-del-ibec-disenan-un-contacto-electrico-con-una-sola-proteina\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/investigadores-del-ibec-disenan-un-contacto-electrico-con-una-sola-proteina\\\/\"},\"author\":{\"name\":\"\u00c0ngels L\u00f3pez\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/person\\\/c212c6b589546130be67986b9290e2b8\"},\"headline\":\"Investigadores del IBEC dise\u00f1an un contacto el\u00e9ctrico con una sola prote\u00edna\",\"datePublished\":\"2017-11-30T16:04:47+00:00\",\"dateModified\":\"2017-12-01T10:42:05+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/investigadores-del-ibec-disenan-un-contacto-electrico-con-una-sola-proteina\\\/\"},\"wordCount\":379,\"publisher\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/investigadores-del-ibec-disenan-un-contacto-electrico-con-una-sola-proteina\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2017\\\/11\\\/azurinJACS.jpg\",\"articleSection\":[\"Noticias de investigaci\u00f3n\"],\"inLanguage\":\"es\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/investigadores-del-ibec-disenan-un-contacto-electrico-con-una-sola-proteina\\\/\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/investigadores-del-ibec-disenan-un-contacto-electrico-con-una-sola-proteina\\\/\",\"name\":\"Investigadores del IBEC dise\u00f1an un contacto el\u00e9ctrico con una sola prote\u00edna - 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