{"id":56710,"date":"2017-12-04T10:01:49","date_gmt":"2017-12-04T09:01:49","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/deciphering-cell-language\/"},"modified":"2020-06-09T10:34:07","modified_gmt":"2020-06-09T08:34:07","slug":"deciphering-cell-language","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/es\/deciphering-cell-language\/","title":{"rendered":"Descifrando el lenguaje de las c\u00e9lulas"},"content":{"rendered":"<h6 class=\"caption\" style=\"float: left; width: 30%; padding: 0px 30px 10px 0px;\">Reconstrucci\u00f3n tridimensional de c\u00e9lulas expresando el receptor EphB2 en la membrana de c\u00e9lulas que han sido estimuladas con el ligando efrina. Se observa como las c\u00e9lulas se contraen dejando un rastro de proyecciones en la base del sustrato.<\/h6>\n<p>\u201cQuer\u00edamos entender este sistema de comunicaci\u00f3n, que es muy sofisticado, al m\u00e1ximo detalle posible. Aunque ya conoc\u00edamos los agentes implicados, hasta ahora no ten\u00edamos las herramientas para descifrar el lenguaje, es decir, su mecanismo de funcionamiento\u201d, comenta Samuel Ojosnegros, primer autor del estudio. Para estudiar los mensajes que se env\u00edan las c\u00e9lulas, en un esfuerzo conjunto entre institutos de Barcelona y de California, los autores han desarrollado una nueva t\u00e9cnica de microscopia que permite observar las se\u00f1ales de comunicaci\u00f3n en c\u00e9lulas vivas. Esta t\u00e9cnica es capaz de resolver a nivel subp\u00edxel la agregaci\u00f3n de prote\u00ednas, que se representa con una escala de colores, y permite registrar secuencias a tiempo real de c\u00f3mo una c\u00e9lula responde a un determinado est\u00edmulo a gran resoluci\u00f3n.<\/p>\n<p>Este sistema de comunicaci\u00f3n lo utilizan las c\u00e9lulas como una especie de GPS interno para llegar a su destino en los \u00f3rganos durante el desarrollo embrionario, la regeneraci\u00f3n de c\u00e9lulas madre y durante las met\u00e1stasis de tumores invasivos.<\/p>\n<p>Una de las limitaciones actuales de la medicina regenerativa es la dificultad de asegurar que las c\u00e9lulas madre trasplantadas a un paciente lleguen y se implanten en el destino deseado. \u201cUna vez descrito este mecanismo, hemos dado el primer paso de cara a ser capaces de manipularlo para redirigir las c\u00e9lulas madre de forma mucho m\u00e1s eficiente, ya que se trata del sistema que ellas utilizan de manera natural\u201d, apunta el investigador del CMR[B].<\/p>\n<p><strong>Condensaci\u00f3n versus polimerizaci\u00f3n<\/strong><\/p>\n<p>La comunicaci\u00f3n entre c\u00e9lulas es un proceso muy preciso basado en la existencia de prote\u00ednas receptoras de membrana que son capaces de captar se\u00f1ales externas del entorno y traducirlas a nivel interno. En el estudio, el equipo del CMR[B] se ha centrado en los receptores de membrana Eph y su ligando efrina.<\/p>\n<p>\u201cGracias a nuestras t\u00e9cnicas de microscopia, hemos observado que el receptor Eph, en presencia de efrina, empieza a agregarse formando grandes estructuras. Esta agregaci\u00f3n no es homog\u00e9nea, sino que sigue dos patrones diferenciados, que hemos denominado polimerizaci\u00f3n (uni\u00f3n de mon\u00f3meros) y condensaci\u00f3n (uni\u00f3n de olig\u00f3meros). El balance entre estos dos procesos regula el rango din\u00e1mico de respuesta, ya que si bien la polimerizaci\u00f3n implica la activaci\u00f3n de los mon\u00f3meros, en la condensaci\u00f3n el agregado es absorbido por la c\u00e9lula cortando la se\u00f1al\u201d, explica el Dr. Ojosnegros.<\/p>\n<p>&#8212;<\/p>\n<p><em><strong>Art\u00edculo de referencia 1: <\/strong><\/em>Ojosnegros, S., Cutrale, F., Rodr\u00edgues, D., Otterstrom, JJ., Chiu, CL., Hortig\u00fcela, V., Tarantino, C., Seriola, A., Mieruszynski, S., Martinez, E., Lakadamyali, M., Raya, A., Fraser, Se. (2017) <a href=\"http:\/\/www.pnas.org\/content\/early\/2017\/11\/29\/1713564114.short\" target=\"_blank\" rel=\"noopener noreferrer\">Eph-ephrin signaling modulated by polymerization and condensation of receptors.<\/a> PNAS, epub ahead of print<\/p>\n<p><em><strong>Art\u00edculo de referencia 2: <\/strong><\/em>Ver\u00f3nica Hortig\u00fcela, Enara Larra\u00f1aga, Francesco Cutrale, Anna Seriola, Mar\u00eda Garc\u00eda-D\u00edaz, Anna Lagunas, Jordi Andilla, Pablo Loza-Alvarez, Josep Samitier, Samuel Ojosnegros, Elena Mart\u00ednez (2017) <a href=\"http:\/\/www.pnas.org\/content\/early\/2017\/11\/29\/1713564114.short\" target=\"_blank\" rel=\"noopener noreferrer\">Nanopatterns of surface-bound ephrinB1 produce multivalent ligand-receptor interactions that tune EphB2 receptor clustering.<\/a> NANO Letters, epub ahead of print<\/p>\n","protected":false},"excerpt":{"rendered":"<h3><a href=\"https:\/\/ibecbarcelona.eu\/imaris-snapshot\/\"><img decoding=\"async\" class=\"left size-full wp-image-56703 lazyload\" data-src=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2017\/12\/elenawebdec17.jpg\" alt=\"\" width=\"450\" height=\"261\" data-srcset=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2017\/12\/elenawebdec17.jpg 450w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2017\/12\/elenawebdec17-300x174.jpg 300w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2017\/12\/elenawebdec17-224x130.jpg 224w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2017\/12\/elenawebdec17-150x87.jpg 150w\" data-sizes=\"(max-width: 450px) 100vw, 450px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 450px; --smush-placeholder-aspect-ratio: 450\/261;\" \/><\/a>Conocer el mecanismo de comunicaci\u00f3n intercelular que regula el posicionamiento de c\u00e9lulas abre camino hacia el desarrollo de terapias dirigidas en medicina regenerativa<\/h3>\n<p>Conocer el lenguaje de las c\u00e9lulas para poder redirigirlas hacia donde sea necesario. Esta es una de las posibilidades abiertas por los investigadores del Centro de Medicina Regenerativa de Barcelona (CMR[B]), liderados por el Dr. Samuel Ojosnegros,  que han conseguido describir en su \u00faltimo estudio el mecanismo de comunicaci\u00f3n intercelular implicado en el posicionamiento de las c\u00e9lulas. <\/p>\n<p>El trabajo, publicado por la prestigiosa revista Proceedings of  the National Academy of Sciences (PNAS), cuenta con la colaboraci\u00f3n de los grupos de Elena Mart\u00ednez (IBEC) y Melike Lakadamyali (ICFO), entre otros.  La fruct\u00edfera colaboraci\u00f3n tambi\u00e9n ha dado lugar a la publicaci\u00f3n del trabajo de Ver\u00f3nica Hortig\u00fcela, ex estudiante de doctorado en el grupo de Elena, que ha dise\u00f1ado un patr\u00f3n nanom\u00e9trico de prote\u00ednas que permite controlar este mecanismo de comunicaci\u00f3n.<\/p>\n","protected":false},"author":4,"featured_media":56703,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[97],"tags":[825,1072],"post_formats":[],"class_list":["post-56710","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias-de-investigacion","tag-elena-martinez-es","tag-samuel-ojosnegros-es"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Descifrando el lenguaje de las c\u00e9lulas - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/es\/deciphering-cell-language\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Descifrando el lenguaje de las c\u00e9lulas - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Conocer el mecanismo de comunicaci\u00f3n intercelular que regula el posicionamiento de c\u00e9lulas abre camino hacia el desarrollo de terapias dirigidas en medicina regenerativa Conocer el lenguaje de las c\u00e9lulas para poder redirigirlas hacia donde sea necesario. Esta es una de las posibilidades abiertas por los investigadores del Centro de Medicina Regenerativa de Barcelona (CMR[B]), liderados por el Dr. Samuel Ojosnegros, que han conseguido describir en su \u00faltimo estudio el mecanismo de comunicaci\u00f3n intercelular implicado en el posicionamiento de las c\u00e9lulas.   El trabajo, publicado por la prestigiosa revista Proceedings of the National Academy of Sciences (PNAS), cuenta con la colaboraci\u00f3n de los grupos de Elena Mart\u00ednez (IBEC) y Melike Lakadamyali (ICFO), entre otros. La fruct\u00edfera colaboraci\u00f3n tambi\u00e9n ha dado lugar a la publicaci\u00f3n del trabajo de Ver\u00f3nica Hortig\u00fcela, ex estudiante de doctorado en el grupo de Elena, que ha dise\u00f1ado un patr\u00f3n nanom\u00e9trico de prote\u00ednas que permite controlar este mecanismo de comunicaci\u00f3n.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ibecbarcelona.eu\/es\/deciphering-cell-language\/\" \/>\n<meta property=\"og:site_name\" content=\"Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"article:published_time\" content=\"2017-12-04T09:01:49+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-06-09T08:34:07+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2017\/12\/elenawebdec17.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"450\" \/>\n\t<meta property=\"og:image:height\" content=\"261\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"\u00c0ngels L\u00f3pez\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"\u00c0ngels L\u00f3pez\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/deciphering-cell-language\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/deciphering-cell-language\\\/\"},\"author\":{\"name\":\"\u00c0ngels L\u00f3pez\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/person\\\/c212c6b589546130be67986b9290e2b8\"},\"headline\":\"Descifrando el lenguaje de las c\u00e9lulas\",\"datePublished\":\"2017-12-04T09:01:49+00:00\",\"dateModified\":\"2020-06-09T08:34:07+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/deciphering-cell-language\\\/\"},\"wordCount\":574,\"publisher\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/deciphering-cell-language\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2017\\\/12\\\/elenawebdec17.jpg\",\"keywords\":[\"Elena Martinez\",\"samuel ojosnegros\"],\"articleSection\":[\"Noticias de investigaci\u00f3n\"],\"inLanguage\":\"es\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/deciphering-cell-language\\\/\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/deciphering-cell-language\\\/\",\"name\":\"Descifrando el lenguaje de las c\u00e9lulas - 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