{"id":56755,"date":"2017-12-11T09:33:55","date_gmt":"2017-12-11T08:33:55","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/cells-feel-their-environment-to-explore-it\/"},"modified":"2017-12-11T10:20:30","modified_gmt":"2017-12-11T09:20:30","slug":"cells-feel-their-environment-to-explore-it","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/es\/cells-feel-their-environment-to-explore-it\/","title":{"rendered":"Las c\u00e9lulas tantean su entorno para explorarlo"},"content":{"rendered":"<p>La interacci\u00f3n entre las c\u00e9lulas y sus ligandos (o microentorno celular) es esencial para mantener la funci\u00f3n de cualquier tejido, y de hecho la detecci\u00f3n de cambios en el entorno celular es fundamental en cualquier escenario donde haya una remodelaci\u00f3n de tejido, como puede ser el desarrollo embrionario, la proliferaci\u00f3n tumoral o el proceso con el cual se cierra una herida.<\/p>\n<p>En el trabajo tambi\u00e9n se ha visto c\u00f3mo, \u201cen funci\u00f3n de esta distribuci\u00f3n de fuerzas de la c\u00e9lula se incide en la activaci\u00f3n de la transcripci\u00f3n gen\u00e9tica, fen\u00f3meno que determina qu\u00e9 genes se expresan\u201d, apunta Roger Oria, primer autor del estudio y estudiante de doctorado en el laboratorio del Dr. Roca-Cusachs.<\/p>\n<p>Con este conocimiento m\u00e1s integrado de c\u00f3mo la c\u00e9lula detecta su entorno, los investigadores han comprobado que modificando las condiciones del entorno de la c\u00e9lula (rigidez y distribuci\u00f3n de los ligandos que forman la matriz extracelular) se puede controlar la respuesta de adherencia de la c\u00e9lula e, incluso, definir un rango en el cual la c\u00e9lula se adhiere y fuera del cual no lo hace. Este resultado, apunta Roca-Cusachs, puede ser especialmente relevante en procesos tumorales, dado que est\u00e1 bastante aceptado que una mayor rigidez est\u00e1 relacionada con una mayor activaci\u00f3n de los oncogenes.<\/p>\n<p>Hasta ahora se sab\u00eda que las c\u00e9lulas son capaces de percibir informaci\u00f3n espacial y f\u00edsica en la nanoescala. De hecho, se pensaba que eran capaces de \u201cmedir distancias\u201d y por eso se hab\u00eda hipotetizado con la existencia de alg\u00fan tipo de mol\u00e9cula patr\u00f3n que las ayudara en este proceso. Este trabajo \u201ccontradice\u201d esta hip\u00f3tesis, afirma el investigador IBEC-UB, demostrando que las c\u00e9lulas tantean m\u00e1s que ven su entorno.<\/p>\n<p>Para llevar a cabo el trabajo, los investigadores han desarrollado unos sustratos de geles blandos en los cuales se incorpora un patr\u00f3n de nanoesferas de oro recubiertas de una prote\u00edna y de las cuales pueden controlar su separaci\u00f3n. La c\u00e9lula reconoce estas nanoesferas como un ligando y por lo tanto se puede medir de qu\u00e9 manera las c\u00e9lulas modulan la distribuci\u00f3n de fuerzas y el n\u00famero de ligandos a los cuales se adhieren en funci\u00f3n de la densidad.<\/p>\n<p>En este estudio han colaborado, entre otros, el Instituto de Investigaci\u00f3n en Ingenier\u00eda de Arag\u00f3n de la Universidad de Zaragoza, el Instituto Max Planck y la Universidad Heidelberg en Alemania.<\/p>\n<p>Este trabajo ha sido financiado por la Comisi\u00f3n Europea, el Ministerio de Econom\u00eda y Competitividad de Espa\u00f1a, el Consejo Europeo de Investigaci\u00f3n, la Fundaci\u00f3n Bancaria \u201cla Caixa\u201d, la Fundaci\u00f3n la Marat\u00f3 de Tv3 y la Fundaci\u00f3n Alemana de Ciencias.<\/p>\n<p>&#8212;<br \/>\n<strong><br \/>\nArticle citation:<\/strong><em><br \/>\n<\/em>Oria R, Wiegand T, Escribano J, Elosegui-Artola A, Uriarte JJ, Moreno-Pulido C, Platzman I, Delcanale P, Albertazzi L, Navajas D, Trepat X, Garc\u00eda-Aznar JM, Cavalcanti-Adam EA, Roca-Cusachs P. (2017). <a href=\"https:\/\/www.nature.com\/articles\/nature24662\" target=\"_blank\" rel=\"noopener\">Force loading explains spatial sensing of ligands by cells<\/a>. <em>Nature<\/em>, epub ahead of print<\/p>\n<p><em>The work also involved researchers at the Instituto de Investigaci\u00f3n en Ingenier\u00eda de Arag\u00f3n of the University of Zaragoza and Germany\u2019s Max Planck Institute for Medical Research and Heidelberg University. It was funded by the European Commission, MINECO, the Generalitat de Catalunya, the European Research Council, the \u00abLa Caixa\u00bb Foundation, La Marato de TV3 and the German Science Foundation (DFG).<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<h3><a href=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2017\/12\/nature_procaweb.jpg\"><img decoding=\"async\" data-src=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2017\/12\/nature_procaweb.jpg\" alt=\"\" width=\"400\" height=\"411\" class=\"left size-full wp-image-56751 lazyload\" data-srcset=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2017\/12\/nature_procaweb.jpg 400w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2017\/12\/nature_procaweb-292x300.jpg 292w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2017\/12\/nature_procaweb-127x130.jpg 127w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2017\/12\/nature_procaweb-146x150.jpg 146w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2017\/12\/nature_procaweb-45x45.jpg 45w\" data-sizes=\"(max-width: 400px) 100vw, 400px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 400px; --smush-placeholder-aspect-ratio: 400\/411;\" \/><\/a>El proceso mediante el cual las c\u00e9lulas son capaces de percibir su entorno est\u00e1 regulado por la detecci\u00f3n de fuerzas. Esta es la principal conclusi\u00f3n de un estudio publicado en la revista <em>Nature<\/em> liderado por el equipo de Pere Roca-Cusachs, investigador principal del IBEC y profesor de la UB, y que est\u00e1 impulsado por la Fundaci\u00f3n Bancaria \u201cla Caixa\u201d. <\/h3>\n<p>\u201cEn nuestra investigaci\u00f3n hemos determinado c\u00f3mo las c\u00e9lulas detectan la posici\u00f3n de las mol\u00e9culas (o ligandos) de su entorno, con precisi\u00f3n nanom\u00e9trica\u201d, explica Roca-Cusachs. \u201cAl adherirse a sus ligandos, las c\u00e9lulas aplican una fuerza que pueden detectar. Como esta fuerza depende de la distribuci\u00f3n espacial de los ligandos, esto permite a las c\u00e9lulas tantean su entorno. De alguna manera, ser\u00eda equivalente a reconocer la cara de alguien a oscuras resigui\u00e9ndola con una mano, m\u00e1s que viendo la persona\u201d. <\/p>\n","protected":false},"author":4,"featured_media":56751,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[97],"tags":[],"post_formats":[],"class_list":["post-56755","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias-de-investigacion"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Las c\u00e9lulas tantean su entorno para explorarlo - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/es\/cells-feel-their-environment-to-explore-it\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Las c\u00e9lulas tantean su entorno para explorarlo - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"El proceso mediante el cual las c\u00e9lulas son capaces de percibir su entorno est\u00e1 regulado por la detecci\u00f3n de fuerzas. Esta es la principal conclusi\u00f3n de un estudio publicado en la revista Nature liderado por el equipo de Pere Roca-Cusachs, investigador principal del IBEC y profesor de la UB, y que est\u00e1 impulsado por la Fundaci\u00f3n Bancaria \u201cla Caixa\u201d.   \u201cEn nuestra investigaci\u00f3n hemos determinado c\u00f3mo las c\u00e9lulas detectan la posici\u00f3n de las mol\u00e9culas (o ligandos) de su entorno, con precisi\u00f3n nanom\u00e9trica\u201d, explica Roca-Cusachs. \u201cAl adherirse a sus ligandos, las c\u00e9lulas aplican una fuerza que pueden detectar. Como esta fuerza depende de la distribuci\u00f3n espacial de los ligandos, esto permite a las c\u00e9lulas tantean su entorno. De alguna manera, ser\u00eda equivalente a reconocer la cara de alguien a oscuras resigui\u00e9ndola con una mano, m\u00e1s que viendo la persona\u201d.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ibecbarcelona.eu\/es\/cells-feel-their-environment-to-explore-it\/\" \/>\n<meta property=\"og:site_name\" content=\"Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"article:published_time\" content=\"2017-12-11T08:33:55+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2017-12-11T09:20:30+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2017\/12\/nature_procaweb.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"400\" \/>\n\t<meta property=\"og:image:height\" content=\"411\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"\u00c0ngels L\u00f3pez\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"\u00c0ngels L\u00f3pez\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/cells-feel-their-environment-to-explore-it\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/cells-feel-their-environment-to-explore-it\\\/\"},\"author\":{\"name\":\"\u00c0ngels L\u00f3pez\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/person\\\/c212c6b589546130be67986b9290e2b8\"},\"headline\":\"Las c\u00e9lulas tantean su entorno para explorarlo\",\"datePublished\":\"2017-12-11T08:33:55+00:00\",\"dateModified\":\"2017-12-11T09:20:30+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/cells-feel-their-environment-to-explore-it\\\/\"},\"wordCount\":591,\"publisher\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/cells-feel-their-environment-to-explore-it\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2017\\\/12\\\/nature_procaweb.jpg\",\"articleSection\":[\"Noticias de investigaci\u00f3n\"],\"inLanguage\":\"es\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/cells-feel-their-environment-to-explore-it\\\/\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/cells-feel-their-environment-to-explore-it\\\/\",\"name\":\"Las c\u00e9lulas tantean su entorno para explorarlo - 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