{"id":56973,"date":"2017-12-15T14:17:01","date_gmt":"2017-12-15T13:17:01","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=56973"},"modified":"2017-12-19T13:57:22","modified_gmt":"2017-12-19T12:57:22","slug":"los-nanomotores-enzimaticos-liberan-medicamentos-contra-el-cancer-de-manera-mas-eficiente","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/es\/los-nanomotores-enzimaticos-liberan-medicamentos-contra-el-cancer-de-manera-mas-eficiente\/","title":{"rendered":"Los nanomotores enzim\u00e1ticos liberan medicamentos contra el c\u00e1ncer de manera m\u00e1s eficiente"},"content":{"rendered":"<p>Los investigadores muestran que sus nanomotores (nanobots) propulsados con ureasa son sistemas de administraci\u00f3n eficientes para el f\u00e1rmaco Dox contra el c\u00e1ncer. El an\u00e1lisis confirma que estos nanobots mesoporosos de estructura multicapa y fabricados con s\u00edlice son capaces de autopropulsarse en medios i\u00f3nicos, y se detect\u00f3 un mayor contenido de Dox dentro de las c\u00e9lulas HeLa despu\u00e9s de una, cuatro, seis y 24 horas de incubaci\u00f3n usando las nanopart\u00edculas activas comparando con los nanomotores pasivos cargados con el mismo f\u00e1rmaco.<\/p>\n<p>\u00abEsta alta eficacia contra el c\u00e1ncer es el resultado de una mayor liberaci\u00f3n del f\u00e1rmaco que funciona en sinergia con el amon\u00edaco producido en altas concentraciones por el sustrato de urea\u00bb, dice el profesor de investigaci\u00f3n ICREA Samuel.<\/p>\n<p>La mejora lograda por los nanobots propulsados por enzimas en la administraci\u00f3n de f\u00e1rmacos puede tener potencial para su uso futuro en aplicaciones biom\u00e9dicas, como la liberaci\u00f3n de f\u00e1rmacos al contacto con sustratos espec\u00edficos en ubicaciones espec\u00edficas.<\/p>\n<p>&#8212;<\/p>\n<p><em><strong>Art\u00edculo referenciado:<\/strong> <\/em>Ana C. Hortel\u00e3o, Tania Pati\u00f1o, Ariadna Perez-Jim\u00e9nez, \u00c0ngel Blanco &amp; Samuel S\u00e1nchez (2017). Enzyme-Powered Nanobots Enhance Anticancer Drug Delivery. <em>Advanced Functional Materials<\/em>, epub ahead of print.<\/p>\n","protected":false},"excerpt":{"rendered":"<h3><a href=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2017\/12\/enzymeanticancer.jpg\"><img decoding=\"async\" class=\"align size-full wp-image-56937 lazyload\" data-src=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2017\/12\/enzymeanticancer.jpg\" alt=\"\" width=\"433\" height=\"239\" data-srcset=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2017\/12\/enzymeanticancer.jpg 433w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2017\/12\/enzymeanticancer-300x166.jpg 300w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2017\/12\/enzymeanticancer-230x127.jpg 230w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2017\/12\/enzymeanticancer-150x83.jpg 150w\" data-sizes=\"(max-width: 433px) 100vw, 433px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 433px; --smush-placeholder-aspect-ratio: 433\/239;\" \/><\/a>Investigadores del IBEC han demostrado que sus nanorobots propulsados con enzimas mejoran la administraci\u00f3n de f\u00e1rmacos en comparaci\u00f3n con los nanorobots pasivos.<\/h3>\n<p>El art\u00edculo, publicado en  <em>Advanced Functional Materials<\/em>, es el resultado de dos a\u00f1os de trabajo en el IBEC, en los que <a href=\"https:\/\/ibecbarcelona.eu\/nanodevices\" target=\"_blank\" rel=\"noopener\"> el grupo de Samuel S\u00e1nchez<\/a> ha estado experimentando con la cat\u00e1lisis enzim\u00e1tica para impulsar micro y nanomotores. Al consumir combustibles biocompatibles, estas nanopart\u00edculas se pueden utilizar para aplicaciones biom\u00e9dicas, como la administraci\u00f3n dirigida de f\u00e1rmacos a las c\u00e9lulas cancerosas.<\/p>\n","protected":false},"author":4,"featured_media":56937,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[97],"tags":[],"post_formats":[],"class_list":["post-56973","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias-de-investigacion"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Los nanomotores enzim\u00e1ticos liberan medicamentos contra el c\u00e1ncer de manera m\u00e1s eficiente - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/es\/los-nanomotores-enzimaticos-liberan-medicamentos-contra-el-cancer-de-manera-mas-eficiente\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Los nanomotores enzim\u00e1ticos liberan medicamentos contra el c\u00e1ncer de manera m\u00e1s eficiente - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Investigadores del IBEC han demostrado que sus nanorobots propulsados con enzimas mejoran la administraci\u00f3n de f\u00e1rmacos en comparaci\u00f3n con los nanorobots pasivos.   El art\u00edculo, publicado en Advanced Functional Materials, es el resultado de dos a\u00f1os de trabajo en el IBEC, en los que el grupo de Samuel S\u00e1nchez ha estado experimentando con la cat\u00e1lisis enzim\u00e1tica para impulsar micro y nanomotores. Al consumir combustibles biocompatibles, estas nanopart\u00edculas se pueden utilizar para aplicaciones biom\u00e9dicas, como la administraci\u00f3n dirigida de f\u00e1rmacos a las c\u00e9lulas cancerosas.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ibecbarcelona.eu\/es\/los-nanomotores-enzimaticos-liberan-medicamentos-contra-el-cancer-de-manera-mas-eficiente\/\" \/>\n<meta property=\"og:site_name\" content=\"Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"article:published_time\" content=\"2017-12-15T13:17:01+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2017-12-19T12:57:22+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2017\/12\/enzymeanticancer.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"433\" \/>\n\t<meta property=\"og:image:height\" content=\"239\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"\u00c0ngels L\u00f3pez\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"\u00c0ngels L\u00f3pez\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minuto\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/los-nanomotores-enzimaticos-liberan-medicamentos-contra-el-cancer-de-manera-mas-eficiente\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/los-nanomotores-enzimaticos-liberan-medicamentos-contra-el-cancer-de-manera-mas-eficiente\\\/\"},\"author\":{\"name\":\"\u00c0ngels L\u00f3pez\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/person\\\/c212c6b589546130be67986b9290e2b8\"},\"headline\":\"Los nanomotores enzim\u00e1ticos liberan medicamentos contra el c\u00e1ncer de manera m\u00e1s eficiente\",\"datePublished\":\"2017-12-15T13:17:01+00:00\",\"dateModified\":\"2017-12-19T12:57:22+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/los-nanomotores-enzimaticos-liberan-medicamentos-contra-el-cancer-de-manera-mas-eficiente\\\/\"},\"wordCount\":225,\"publisher\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/los-nanomotores-enzimaticos-liberan-medicamentos-contra-el-cancer-de-manera-mas-eficiente\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2017\\\/12\\\/enzymeanticancer.jpg\",\"articleSection\":[\"Noticias de investigaci\u00f3n\"],\"inLanguage\":\"es\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/los-nanomotores-enzimaticos-liberan-medicamentos-contra-el-cancer-de-manera-mas-eficiente\\\/\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/los-nanomotores-enzimaticos-liberan-medicamentos-contra-el-cancer-de-manera-mas-eficiente\\\/\",\"name\":\"Los nanomotores enzim\u00e1ticos liberan medicamentos contra el c\u00e1ncer de manera m\u00e1s eficiente - 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