{"id":57000,"date":"2017-12-20T12:34:50","date_gmt":"2017-12-20T11:34:50","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/a-molecular-mechanism-could-explain-how-bacteria-resist-antibiotics\/"},"modified":"2017-12-20T13:35:46","modified_gmt":"2017-12-20T12:35:46","slug":"a-molecular-mechanism-could-explain-how-bacteria-resist-antibiotics","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/es\/a-molecular-mechanism-could-explain-how-bacteria-resist-antibiotics\/","title":{"rendered":"Un mecanismo molecular podr\u00eda explicar c\u00f3mo las bacterias resisten a los antibi\u00f3ticos"},"content":{"rendered":"<p>El grupo de <a href=\"https:\/\/ibecbarcelona.eu\/bactinf\">Infecciones bacterianas: terapias antirmicrobianas<\/a>, liderado por el Dr. Eduard Torrents, se ha especializado en el estudio de la cepa bacteriana <em>Pseudomonas aeruginosa<\/em>, una cepa que puede causar infecciones pulmonares cr\u00f3nicas graves en pacientes con fibrosis qu\u00edstica (FC) a los que da\u00f1a gravemente la funci\u00f3n pulmonar, aumentando el riesgo de insuficiencia respiratoria e incluso causando la muerte.<\/p>\n<p>La ribonucle\u00f3tido reductasa (RNR) es una enzima esencial para la divisi\u00f3n celular que suministra los mon\u00f3meros necesarios para la s\u00edntesis y reparaci\u00f3n del ADN, y es la principal responsable de mantener el ciclo celular bacteriano equilibrado en diferentes condiciones. El hecho de que la\u00a0<em>P. aeruginosa<\/em> sea uno de los pocos microorganismos que codifica tres clases diferentes de ribonucle\u00f3tido reductasa (RNR) en su genoma es lo que le permite crecer y adaptarse a diversas condiciones ambientales, pudiendo prosperar y causar infecci\u00f3n en m\u00faltiples escenarios.<\/p>\n<p>Uno de los sistemas reguladores globales de la <em>P. aeruginosa<\/em>, AlgZR, es el responsable de convertir las bacterias en el fenotipo asociado a la enfermedad cr\u00f3nica, conocido como mucoide. Estudiando la regulaci\u00f3n de la RNR en bacterias bajo condiciones estresantes, como el estr\u00e9s oxidativo -una perturbaci\u00f3n en el equilibrio entre la producci\u00f3n de radicales libres y defensas antioxidantes- los investigadores, incluyendo miembros del grupo de Gabriel Gomila <a href=\"https:\/\/ibecbarcelona.eu\/nanobioelec\">Nanoscale bioelectrical characterization<\/a>, descubrieron que AlgZR tambi\u00e9n controla la red de la RNR y dirige c\u00f3mo se modula la s\u00edntesis de ADN, permitiendo a las bacterias reaccionar ante estas condiciones. Esta respuesta tambi\u00e9n podr\u00eda explicar c\u00f3mo las bacterias reaccionan o se adaptan a otras situaciones estresantes, como al hecho de ser atacadas por antibi\u00f3ticos.<\/p>\n<p>\u201cEste v\u00ednculo entre el estr\u00e9s, el sistema AlgZR y la regulaci\u00f3n de la RNR proporciona, por primera vez, una explicaci\u00f3n molecular de c\u00f3mo las bacterias pueden continuar dividi\u00e9ndose bajo el tratamiento con antibi\u00f3ticos\u201d, comenta el Dr. Torrents. \u201cEn la mayor\u00eda de las especies bacterianas, existen sistemas de dos componentes similares a AlgZR, por lo que se llevar\u00e1n a cabo m\u00e1s experimentos para evaluar si estos resultados son extensibles a otras especies bacterianas\u201d.<\/p>\n<p>A finales de 2016, la l\u00ednea de investigaci\u00f3n sobre fibrosis qu\u00edstica del grupo de Eduard Torrents recibi\u00f3 financiaci\u00f3n de la Fundaci\u00f3n \u00abLa Caixa\u00bb, un impulso que se extender\u00e1 durante 3 a\u00f1os.<\/p>\n<p>&#8212;<\/p>\n<p><em><strong>Art\u00edculo referenciado: <\/strong><\/em>Anna Crespo, Lucas Pedraz, Marc Van Der Hofstadt, Gabriel Gomila &amp; Eduard Torrents (2017). <a href=\"https:\/\/www.nature.com\/articles\/s41598-017-17917-7\" target=\"_blank\" rel=\"noopener\">Regulation of ribonucleotide synthesis by the Pseudomonas aeruginosa two-component system AlgR in response to oxidative stress<\/a>. <em>Scientific Reports<\/em> 7, Article number: 17892<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<h3><a href=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2017\/12\/ETorrents_2web.jpg\"><img decoding=\"async\" class=\"left size-full wp-image-56995 lazyload\" data-src=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2017\/12\/ETorrents_2web.jpg\" alt=\"\" width=\"450\" height=\"253\" data-srcset=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2017\/12\/ETorrents_2web.jpg 450w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2017\/12\/ETorrents_2web-300x169.jpg 300w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2017\/12\/ETorrents_2web-230x130.jpg 230w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2017\/12\/ETorrents_2web-150x84.jpg 150w\" data-sizes=\"(max-width: 450px) 100vw, 450px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 450px; --smush-placeholder-aspect-ratio: 450\/253;\" \/><\/a>Este descubrimiento, llevado a cabo por investigadores del IBEC, podr\u00eda ayudar a desarrollar nuevos antibi\u00f3ticos contra las bacterias superresistentes.<\/h3>\n<h3>El estudio publicado en la revista <em>Scientific Reports<\/em> est\u00e1 liderado por un equipo de investigadores del IBEC e impulsado por la Fundaci\u00f3n Bancaria \u201cla Caixa\u201d.<\/h3>\n<p>Investigadores del IBEC han demostrado por primera vez c\u00f3mo las bacterias producen ADN en condiciones adversas, como cuando est\u00e1n sometidas a tratamientos farmacol\u00f3gicos.<\/p>\n","protected":false},"author":4,"featured_media":56995,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[97],"tags":[],"post_formats":[],"class_list":["post-57000","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias-de-investigacion"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Un mecanismo molecular podr\u00eda explicar c\u00f3mo las bacterias resisten a los antibi\u00f3ticos - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/es\/a-molecular-mechanism-could-explain-how-bacteria-resist-antibiotics\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Un mecanismo molecular podr\u00eda explicar c\u00f3mo las bacterias resisten a los antibi\u00f3ticos - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Este descubrimiento, llevado a cabo por investigadores del IBEC, podr\u00eda ayudar a desarrollar nuevos antibi\u00f3ticos contra las bacterias superresistentes.  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