{"id":58128,"date":"2018-03-20T17:09:55","date_gmt":"2018-03-20T16:09:55","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=58128"},"modified":"2018-03-22T09:55:42","modified_gmt":"2018-03-22T08:55:42","slug":"enzimas-sinteticas-para-la-administracion-controlada-de-farmacos-en-las-celulas","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/es\/enzimas-sinteticas-para-la-administracion-controlada-de-farmacos-en-las-celulas\/","title":{"rendered":"Enzimas sint\u00e9ticas para la administraci\u00f3n controlada de f\u00e1rmacos en las c\u00e9lulas"},"content":{"rendered":"<h6 class=\"caption\" style=\"float: left; width: 30%; padding: 0px 30px 10px 0px;\">Image: Las SCPN activan la fluorescencia localmente (en verde) activando una mol\u00e9cula pro-fluor\u00f3foro.<\/h6>\n<p>Las SCPN son objetos del tama\u00f1o de nan\u00f3metros inspiradas en el funcionamiento de las enzimas; cargan un catalizador que se activa cuando la estructura se pliega. Aunque no se trata de la primera enzima artificial que se propone en el campo, este estudio es el primero en demostrar su viabilidad en entornos complejos como la c\u00e9lula. \u00abEl blindaje que ofrecen las SCPN a los catalizadores sint\u00e9ticos es una forma no t\u00f3xica y biocompatible de contenerlos que funciona en armon\u00eda con lo que ya est\u00e1 sucediendo en la c\u00e9lula\u00bb, dice Silvia Pujals, investigadora postdoctoral en el grupo de Lorenzo Albertazzi en el IBEC. \u00abEn otras palabras, las SCPN no interfieren con el comportamiento normal de las c\u00e9lulas\u00bb.<\/p>\n<p>Las SCPN en estudio se pueden administrar intracelular o extracelularmente dependiendo de la aplicaci\u00f3n prevista. Para aplicaciones de terapia fotodin\u00e1mica (PDT) se necesita una administraci\u00f3n intracelular, mientras que los catalizadores organomet\u00e1licos funcionan bien extracelularmente. Esta \u00faltima aplicaci\u00f3n de las SCPN puede suponer un avance en la administraci\u00f3n controlada de medicamentos. Por ejemplo, las enzimas sint\u00e9ticas podr\u00edan activar f\u00e1rmacos antitumorales administrados a trav\u00e9s de la corriente sangu\u00ednea justo en el \u00e1rea del tumor. \u00abHasta ahora, hemos obtenido resultados prometedores activando localmente un fluor\u00f3foro con los SCPN como catalizadores en las \u00e1reas expuestas a las mismas\u00bb, dice Lorenzo. \u00abCreemos que estas nanopart\u00edculas similares a enzimas podr\u00edan usarse para su actividad pro-f\u00e1rmaco en diferentes aplicaciones biom\u00e9dicas \u00ab.<\/p>\n<p>&#8212;<\/p>\n<p><em><strong>Art\u00edculo referenciado:<\/strong> <\/em>Yiliu Liu, Silvia Pujals, Patrick J.M. Stals, Thomas Pauloehrl, Stanislav I. Presolski, E. W. Meijer, Lorenzo Albertazzi, and Anja R.A. Palmans (2018). <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29457449\" target=\"_blank\" rel=\"noopener\">Catalytically Active Single-Chain Polymeric Nanoparticles: Exploring Their Functions in Complex Biological Media<\/a>. <em>J. Am. Chem. Soc.<\/em>, 140(9):3423-3433<\/p>\n","protected":false},"excerpt":{"rendered":"<h3><img decoding=\"async\" class=\"left size-full wp-image-58099 lazyload\" data-src=\"http:\/\/www.ibecbarcelona.eu\/wp-content\/uploads\/2018\/03\/nanoparticle_2.png\" alt=\"\" width=\"600\" height=\"300\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 600px; --smush-placeholder-aspect-ratio: 600\/300;\" \/>El grupo <em>Nanoscopy for Nanomedicine<\/em> propone las nanopart\u00edculas polim\u00e9ricas de cadena \u00fanica (SCPN, del ingl\u00e9s <em>Single-Chain Polymeric Nanoparticles<\/em>) que imitan las enzimas como posibles activadores de f\u00e1rmacos en entornos biol\u00f3gicos, como la c\u00e9lula viva.<\/h3>\n<p>Las nanopart\u00edculas de inspiraci\u00f3n biol\u00f3gica podr\u00edan usarse para controlar espacialmente la administraci\u00f3n de f\u00e1rmacos en el tratamiento de enfermedades como el c\u00e1ncer.<\/p>\n<p>A trav\u00e9s de su estudio, publicado en <em>JACS<\/em>, los investigadores han optimizado las estrategias de liberaci\u00f3n de SCPN din\u00e1micas para que conserven su actividad catal\u00edtica en el entorno celular. Esto allana el camino hacia el dise\u00f1o racional de nanosistemas que pueden realizar una cat\u00e1lisis efectiva <em> in vivo <\/em>.<\/p>\n","protected":false},"author":4,"featured_media":58130,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[97],"tags":[],"post_formats":[],"class_list":["post-58128","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias-de-investigacion"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Enzimas sint\u00e9ticas para la administraci\u00f3n controlada de f\u00e1rmacos en las c\u00e9lulas - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/es\/enzimas-sinteticas-para-la-administracion-controlada-de-farmacos-en-las-celulas\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Enzimas sint\u00e9ticas para la administraci\u00f3n controlada de f\u00e1rmacos en las c\u00e9lulas - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"El grupo Nanoscopy for Nanomedicine propone las nanopart\u00edculas polim\u00e9ricas de cadena \u00fanica (SCPN, del ingl\u00e9s Single-Chain Polymeric Nanoparticles) que imitan las enzimas como posibles activadores de f\u00e1rmacos en entornos biol\u00f3gicos, como la c\u00e9lula viva.  Las nanopart\u00edculas de inspiraci\u00f3n biol\u00f3gica podr\u00edan usarse para controlar espacialmente la administraci\u00f3n de f\u00e1rmacos en el tratamiento de enfermedades como el c\u00e1ncer.  A trav\u00e9s de su estudio, publicado en JACS, los investigadores han optimizado las estrategias de liberaci\u00f3n de SCPN din\u00e1micas para que conserven su actividad catal\u00edtica en el entorno celular. Esto allana el camino hacia el dise\u00f1o racional de nanosistemas que pueden realizar una cat\u00e1lisis efectiva in vivo .\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ibecbarcelona.eu\/es\/enzimas-sinteticas-para-la-administracion-controlada-de-farmacos-en-las-celulas\/\" \/>\n<meta property=\"og:site_name\" content=\"Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"article:published_time\" content=\"2018-03-20T16:09:55+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2018-03-22T08:55:42+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2018\/03\/nanoparticle_2.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1002\" \/>\n\t<meta property=\"og:image:height\" content=\"498\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"\u00c0ngels L\u00f3pez\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"\u00c0ngels L\u00f3pez\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/enzimas-sinteticas-para-la-administracion-controlada-de-farmacos-en-las-celulas\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/enzimas-sinteticas-para-la-administracion-controlada-de-farmacos-en-las-celulas\\\/\"},\"author\":{\"name\":\"\u00c0ngels L\u00f3pez\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/person\\\/c212c6b589546130be67986b9290e2b8\"},\"headline\":\"Enzimas sint\u00e9ticas para la administraci\u00f3n controlada de f\u00e1rmacos en las c\u00e9lulas\",\"datePublished\":\"2018-03-20T16:09:55+00:00\",\"dateModified\":\"2018-03-22T08:55:42+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/enzimas-sinteticas-para-la-administracion-controlada-de-farmacos-en-las-celulas\\\/\"},\"wordCount\":327,\"publisher\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/enzimas-sinteticas-para-la-administracion-controlada-de-farmacos-en-las-celulas\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2018\\\/03\\\/nanoparticle_2.png\",\"articleSection\":[\"Noticias de investigaci\u00f3n\"],\"inLanguage\":\"es\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/enzimas-sinteticas-para-la-administracion-controlada-de-farmacos-en-las-celulas\\\/\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/enzimas-sinteticas-para-la-administracion-controlada-de-farmacos-en-las-celulas\\\/\",\"name\":\"Enzimas sint\u00e9ticas para la administraci\u00f3n controlada de f\u00e1rmacos en las c\u00e9lulas - 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