{"id":5957,"date":"2011-07-19T08:04:09","date_gmt":"2011-07-19T08:04:09","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/new\/identificada-una-interaccion-esencial-para-la-epilepsia\/"},"modified":"2015-01-07T13:05:15","modified_gmt":"2015-01-07T13:05:15","slug":"identificada-una-interaccion-esencial-para-la-epilepsia","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/es\/identificada-una-interaccion-esencial-para-la-epilepsia\/","title":{"rendered":"Identificada una interacci\u00f3n esencial para la epilepsia"},"content":{"rendered":"

En el estudio, los investigadores arrojan nueva luz en la importancia de una prote\u00edna neuronal conocida como PrPc, que realiza una serie de funciones fisiol\u00f3gicas en muchos procesos neuronales. Al mutar o plegarse mal, la forma patog\u00e9nica de la prote\u00edna, PrPsc, provoca condiciones progresivas que afectan al cerebro y al sistema nervioso, como la enfermedad de Creutzfeldt-Jakob y la EEB, mientras que en la epilepsia parece que la prote\u00edna sana juega un papel preventivo.<\/p>\n

Estudios previos realizados por el grupo, que colabor\u00f3 con m\u00e9dicos y especialistas en se\u00f1alizaci\u00f3n celular en Barcelona para este \u00faltimo art\u00edculo, hab\u00edan mostrado que la PrPc modula la acci\u00f3n de uno de los llamados receptores de kainato, GluR6, que juega un papel decisivo en la regulaci\u00f3n de la actividad de las redes sin\u00e1pticas. \u201cEl PrPc en las neuronas bloquea el receptor GluR6 e impide su enlace con dos mol\u00e9culas adicionales, PSD95 y MLK3, en la sinapsis neuronal,\u201d explica Patricia Carulla del grupo de Neurobiotecnolog\u00eda Molecular y Celular del IBEC. \u201cLa ausencia de PrPc, sin embargo, permite la formaci\u00f3n de este sistema receptor de tres mol\u00e9culas que a su vez lleva a la activaci\u00f3n de la v\u00eda JNK3, que resulta en un aumento de la epilepsia y la mortandad celular en el hipocampo.\u201d<\/p>\n

Los investigadores determinaron el objetivo final de la activaci\u00f3n de la GluR6 dentro de las c\u00e9lulas trabajando junto a especialistas en se\u00f1alizaci\u00f3n celular para generar imitaciones in vivo de la PrPc y la JNK3. \u201cEn ausencia tanto de la prote\u00edna PrPc como de la v\u00eda JNK3, desaparece la susceptibilidad\u00a0 a la epilepsia experimental: la GluR6 sigue adelante y se enlaza con las otras dos mol\u00e9culas, pero la fase de la JNK3 no se da a continuaci\u00f3n,\u201d dice el responsable del grupo, Jos\u00e9 Antonio del R\u00edo. \u201cEsto muestra que la modulaci\u00f3n que la PrPc ejerce sobre la actividad de la GluR6 juega un papel clave en la activaci\u00f3n de la v\u00eda que lleva a la enfermedad.\u201d<\/p>\n

Ahora, el grupo especula que un efecto protector de la PrPc parecido pueda darse en otros da\u00f1os cerebrales que comparten un sistema de activaci\u00f3n similar \u2013 en los que la se\u00f1alizaci\u00f3n se transmite a trav\u00e9s de la GluR6-PSD-95-MLK3 hasta la v\u00eda JNK3 \u2013 aunque har\u00e1n falta m\u00e1s estudios para confirmar esto. \u201cSe ha hallado un incremento en los niveles de PrPc en afectados por accidentes cerebrovasculares,\u201d dice Jos\u00e9 Antonio. \u201cDeterminar sus papeles funcionales en las sinapsis, adem\u00e1s de sus interacciones espec\u00edficas en condiciones normales y patol\u00f3gicas podr\u00eda ayudarnos a comprender otras enfermedades neurodegenerativas o los efectos de la isquemia (reducci\u00f3n del flujo sangu\u00edneo) en el cerebro.\u201d <\/p>\n

\u00a0<\/p>\n

Fuente: <\/strong>Carulla P, Bribi\u00e1n A, Rangel A, Gav\u00edn R, Ferrer I, Caelles C, Del R\u00edo JA, Llorens F. (2011). Neuroprotective role of PrPC against Kainate-induced epileptic seizures and cell death depends on the modulation of JNK3 activation by GluR6\/7-PSD-95 binding<\/a>. Mol Biol Cell<\/em>, in press<\/p>\n

\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"

Cient\u00edficos del Instituto de Bioingenier\u00eda de Catalunya (IBEC) describen un gran paso hacia la comprensi\u00f3n de la epilepsia en un art\u00edculo publicado en Molecular Biology of the Cell<\/em>.<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[97],"tags":[],"post_formats":[],"class_list":["post-5957","post","type-post","status-publish","format-standard","hentry","category-noticias-de-investigacion"],"yoast_head":"\nIdentificada una interacci\u00f3n esencial para la epilepsia - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/es\/identificada-una-interaccion-esencial-para-la-epilepsia\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Identificada una interacci\u00f3n esencial para la epilepsia - 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