{"id":59575,"date":"2018-06-07T11:38:00","date_gmt":"2018-06-07T09:38:00","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=59575"},"modified":"2018-06-08T11:34:02","modified_gmt":"2018-06-08T09:34:02","slug":"las-bacterias-tambien-necesitan-vitaminas","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/es\/las-bacterias-tambien-necesitan-vitaminas\/","title":{"rendered":"Las bacterias tambi\u00e9n necesitan vitaminas"},"content":{"rendered":"
Imagen: Modelo de actividad de la ribonucle\u00f3tido reductasa (RNR) y disponibilidad de la vitamina B12 durante el crecimiento de biopel\u00edculas de P. aeruginosa. Los c\u00edrculos anaranjados representan el gradiente de vitamina B12, el azul indica gradientes de concentraci\u00f3n de ox\u00edgeno y el verde indica actividad de la RNR de clase Ia, II y III. <\/h6>\n

Esta biopel\u00edcula no solo mejora la comunicaci\u00f3n c\u00e9lula a c\u00e9lula de las bacterias, permitiendo que la infecci\u00f3n prospere y crezca, sino que tambi\u00e9n ayuda a las c\u00e9lulas a esquivar al sistema inmune y aumenta las posibilidades de desarrollar nuevas resistencias a los antibi\u00f3ticos.
\nEn las bacterias, como en todos los organismos vivos, la enzima ribonucle\u00f3tido reductasa (RNR) es fundamental para la formaci\u00f3n de los componentes necesarios para la s\u00edntesis y reparaci\u00f3n del ADN. P. aeruginosa <\/em> es una de las pocas bacterias que codifica las tres clases conocidas de RNR: Ia, que depende del ox\u00edgeno, y II y III, que son activas en ausencia de ox\u00edgeno. Estos tres tipos de RNR aumentan la capacidad de las bacterias para crecer en diferentes entornos aer\u00f3bicos y anaer\u00f3bicos generados en las biopel\u00edculas; sin ellos, las biopel\u00edculas completamente maduras no podr\u00edan establecerse por s\u00ed mismas.<\/p>\n

Los investigadores han demostrado que la RNR de clase II requiere de vitamina B12 como cofactor para funcionar correctamente. \u00abSab\u00edamos que P. aeruginosa<\/em> sintetiza la vitamina B12 en diferentes reacciones metab\u00f3licas\u00bb, explica Eduard Torrents, investigador principal del grupo del IBEC Bacterial infections: antimicrobial therapies<\/a>. \u00abAhora hemos demostrado que el aumento de los niveles de vitamina B12 durante los crecimientos aer\u00f3bico, estacionario y en biopel\u00edcula activan la actividad de la RNR de clase II, lo que significa que la presencia de esta vitamina es crucial para la actividad de la clase de RNR esencial para la formaci\u00f3n de biopel\u00edculas incluso en condiciones adversas\u00bb.<\/p>\n

Una mejor comprensi\u00f3n de c\u00f3mo las bacterias crean biopel\u00edculas maduras para propagar su infecci\u00f3n podr\u00eda arrojar luz sobre c\u00f3mo abordar esta etapa del ciclo de vida de la P. aeruginosa <\/em> y desarrollar terapias farmacol\u00f3gicas espec\u00edficas y resistentes, esenciales para el tratamiento de infecciones bacterianas cr\u00f3nicas.<\/p>\n

—<\/p>\n

Anna Crespo, N\u00faria Blanco-Cabra and Eduard Torrents (2018). Aerobic Vitamin B12 Biosynthesis Is Essential for Pseudomonas aeruginosa Class II Ribonucleotide Reductase Activity During Planktonic and Biofilm Growth<\/a>. Front. Microbiol.<\/em> 9:986<\/p>\n","protected":false},"excerpt":{"rendered":"

\"\"<\/a>El grupo del IBEC Bacterial infections: antimicrobial therapies ha revelado el papel esencial que desempe\u00f1a una vitamina en el desarrollo de biopel\u00edculas bacterianas. <\/h3>\n

Este nuevo descubrimiento podr\u00eda ayudar a comprender c\u00f3mo se propagan estas bacterias, lo que ayudar\u00e1 a dise\u00f1ar mejores f\u00e1rmacos antibacterianos espec\u00edficos.<\/p>\n

La especie bacteriana P. aeruginosa<\/em> causa infecciones pulmonares cr\u00f3nicas en pacientes con fibrosis qu\u00edstica o enfermedad pulmonar obstructiva cr\u00f3nica (EPOC) al formar una biopel\u00edcula madura, en la que las c\u00e9lulas se adhieren entre s\u00ed y pueden ocupar muchas superficies distintas, lo que les permite crecer y adaptarse.<\/p>\n","protected":false},"author":4,"featured_media":59537,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[97],"tags":[],"post_formats":[],"class_list":["post-59575","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias-de-investigacion"],"yoast_head":"\nLas bacterias tambi\u00e9n necesitan vitaminas - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/es\/las-bacterias-tambien-necesitan-vitaminas\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Las bacterias tambi\u00e9n necesitan vitaminas - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"El grupo del IBEC Bacterial infections: antimicrobial therapies ha revelado el papel esencial que desempe\u00f1a una vitamina en el desarrollo de biopel\u00edculas bacterianas. Este nuevo descubrimiento podr\u00eda ayudar a comprender c\u00f3mo se propagan estas bacterias, lo que ayudar\u00e1 a dise\u00f1ar mejores f\u00e1rmacos antibacterianos espec\u00edficos. La especie bacteriana P. aeruginosa causa infecciones pulmonares cr\u00f3nicas en pacientes con fibrosis qu\u00edstica o enfermedad pulmonar obstructiva cr\u00f3nica (EPOC) al formar una biopel\u00edcula madura, en la que las c\u00e9lulas se adhieren entre s\u00ed y pueden ocupar muchas superficies distintas, lo que les permite crecer y adaptarse.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ibecbarcelona.eu\/es\/las-bacterias-tambien-necesitan-vitaminas\/\" \/>\n<meta property=\"og:site_name\" content=\"Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"article:published_time\" content=\"2018-06-07T09:38:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2018-06-08T09:34:02+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2018\/06\/biofilm.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"450\" \/>\n\t<meta property=\"og:image:height\" content=\"280\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"\u00c0ngels L\u00f3pez\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"\u00c0ngels L\u00f3pez\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/las-bacterias-tambien-necesitan-vitaminas\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/las-bacterias-tambien-necesitan-vitaminas\\\/\"},\"author\":{\"name\":\"\u00c0ngels L\u00f3pez\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/person\\\/c212c6b589546130be67986b9290e2b8\"},\"headline\":\"Las bacterias tambi\u00e9n necesitan vitaminas\",\"datePublished\":\"2018-06-07T09:38:00+00:00\",\"dateModified\":\"2018-06-08T09:34:02+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/las-bacterias-tambien-necesitan-vitaminas\\\/\"},\"wordCount\":416,\"publisher\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/las-bacterias-tambien-necesitan-vitaminas\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2018\\\/06\\\/biofilm.jpg\",\"articleSection\":[\"Noticias de investigaci\u00f3n\"],\"inLanguage\":\"es\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/las-bacterias-tambien-necesitan-vitaminas\\\/\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/las-bacterias-tambien-necesitan-vitaminas\\\/\",\"name\":\"Las bacterias tambi\u00e9n necesitan vitaminas - 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