{"id":60364,"date":"2018-07-10T09:24:52","date_gmt":"2018-07-10T07:24:52","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=60364"},"modified":"2018-07-10T13:45:36","modified_gmt":"2018-07-10T11:45:36","slug":"biomateriales-como-plataformas-de-liberacion-de-senales","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/es\/castano-adv","title":{"rendered":"Biomateriales como plataformas de liberaci\u00f3n de se\u00f1ales"},"content":{"rendered":"
Izquierda: c\u00e9lulas de la piel – fibroblastos d\u00e9rmicos – se diseminan en una matriz de col\u00e1geno 3D. Imagen de Claudia Navarro-Requena<\/h6>\n

\u00abHasta ahora, la aplicaci\u00f3n de estas terapias se ve obstaculizada por los altos costes, la falta de estandarizaci\u00f3n y de escalabilidad de los procesos y los problemas de almacenamiento y regulaci\u00f3n, as\u00ed como por la falta de evidencia real de que funcionen\u00bb, explica Oscar Casta\u00f1o, investigador senior del IBEC y profesor asistente de la UB. \u00abPara abordar esta cuesti\u00f3n, sugerimos concentrarnos en los biomateriales que pueden actuar como plataformas generadoras de est\u00edmulos que promuevan la regeneraci\u00f3n tisular\u00bb.<\/p>\n

Esta estrategia in situ utiliza la propia capacidad de regeneraci\u00f3n del cuerpo movilizando c\u00e9lulas madre end\u00f3genas del hu\u00e9sped o c\u00e9lulas progenitoras espec\u00edficas del tejido en la herida para promover la reparaci\u00f3n y la regeneraci\u00f3n. \u00abEl objetivo ser\u00eda crear microentornos instructivos que combinen soportes de biomateriales con las diferentes se\u00f1ales presentes en la curaci\u00f3n de heridas\u00bb, dice Oscar. \u00abEstos regular\u00edan la entrega espacio-temporal de la se\u00f1alizaci\u00f3n adecuada en funci\u00f3n de los mecanismos biol\u00f3gicos que intervienen\u00bb.<\/p>\n

—<\/p>\n

Oscar Casta\u00f1o, Soledad P\u00e9rez-Amodio, Claudia Navarro-Requena, Miguel Angel Mateos-Timoneda, Elisabeth Engel (2018). Instructive microenvironments in skin wound healing: Biomaterials as signal releasing platforms<\/a>. Advanced Drug Delivery Reviews<\/em>, 129, 95-117<\/p>\n","protected":false},"excerpt":{"rendered":"

\"\"<\/a>El grupo de Biomateriales para terapias regenerativas del IBEC ha publicado una revisi\u00f3n del estado del arte en biomateriales para la curaci\u00f3n de piel que propone un cambio hacia una atenci\u00f3n m\u00e1s personalizada. <\/h3>\n

La cicatrizaci\u00f3n de heridas en la piel funciona reparando y restaurando el tejido a trav\u00e9s de un proceso complejo que involucra diferentes c\u00e9lulas y mol\u00e9culas que regulan la respuesta celular y la remodelaci\u00f3n de la matriz extracelular. El art\u00edculo, que ha sido publicado en Advanced Drug Delivery Reviews<\/em>, comienza resumiendo los \u00faltimos avances en terapias para la curaci\u00f3n, que combinan se\u00f1ales biomoleculares – como factores de crecimiento y citoquinas – con c\u00e9lulas.<\/p>\n","protected":false},"author":4,"featured_media":60317,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[97],"tags":[774],"post_formats":[],"class_list":["post-60364","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias-de-investigacion","tag-elisabeth-engel-es"],"yoast_head":"\nBiomateriales como plataformas de liberaci\u00f3n de se\u00f1ales - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/es\/castano-adv\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Biomateriales como plataformas de liberaci\u00f3n de se\u00f1ales - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"El grupo de Biomateriales para terapias regenerativas del IBEC ha publicado una revisi\u00f3n del estado del arte en biomateriales para la curaci\u00f3n de piel que propone un cambio hacia una atenci\u00f3n m\u00e1s personalizada. La cicatrizaci\u00f3n de heridas en la piel funciona reparando y restaurando el tejido a trav\u00e9s de un proceso complejo que involucra diferentes c\u00e9lulas y mol\u00e9culas que regulan la respuesta celular y la remodelaci\u00f3n de la matriz extracelular. El art\u00edculo, que ha sido publicado en Advanced Drug Delivery Reviews, comienza resumiendo los \u00faltimos avances en terapias para la curaci\u00f3n, que combinan se\u00f1ales biomoleculares - como factores de crecimiento y citoquinas - con c\u00e9lulas.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ibecbarcelona.eu\/es\/castano-adv\/\" \/>\n<meta property=\"og:site_name\" content=\"Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"article:published_time\" content=\"2018-07-10T07:24:52+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2018-07-10T11:45:36+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2018\/07\/skinclaudia.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"450\" \/>\n\t<meta property=\"og:image:height\" content=\"450\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"\u00c0ngels L\u00f3pez\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"\u00c0ngels L\u00f3pez\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minuto\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/castano-adv\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/castano-adv\\\/\"},\"author\":{\"name\":\"\u00c0ngels L\u00f3pez\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/person\\\/c212c6b589546130be67986b9290e2b8\"},\"headline\":\"Biomateriales como plataformas de liberaci\u00f3n de se\u00f1ales\",\"datePublished\":\"2018-07-10T07:24:52+00:00\",\"dateModified\":\"2018-07-10T11:45:36+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/castano-adv\\\/\"},\"wordCount\":237,\"publisher\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/castano-adv\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2018\\\/07\\\/skinclaudia.jpg\",\"keywords\":[\"Elisabeth Engel\"],\"articleSection\":[\"Noticias de investigaci\u00f3n\"],\"inLanguage\":\"es\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/castano-adv\\\/\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/castano-adv\\\/\",\"name\":\"Biomateriales como plataformas de liberaci\u00f3n de se\u00f1ales - 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