{"id":62316,"date":"2018-10-31T17:00:48","date_gmt":"2018-10-31T16:00:48","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=62316"},"modified":"2018-11-02T09:38:49","modified_gmt":"2018-11-02T08:38:49","slug":"investigadores-descubren-celulas-superdeformables","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/es\/investigadores-descubren-celulas-superdeformables\/","title":{"rendered":"Investigadores descubren c\u00e9lulas superdeformables"},"content":{"rendered":"

El equipo, dirigido por Marino Arroyo y Xavier Trepat, desarroll\u00f3 una t\u00e9cnica para someter tejidos epiteliales (capas celulares delgadas que cubren las superficies internas y externas del cuerpo) a deformaciones muy grandes, hasta de cuatro veces su tama\u00f1o original. Estos tejidos son fundamentales para la vida, ya que protegen el cuerpo de la radiaci\u00f3n, los contaminantes y de los pat\u00f3genos. Tambi\u00e9n son los responsables del intercambio de gases en los pulmones, la absorci\u00f3n de nutrientes en el intestino y la excreci\u00f3n de orina en los ri\u00f1ones.<\/p>\n

\"\"<\/a>
C\u00e9lulas superdeformadas rodeadas por otras m\u00ednimamente deformadas. El n\u00facleo celular se muestra en azul, los filamentos de actina en rojo y los filamentos de queratina en verde.<\/figcaption><\/figure>\n

\u201cLa mayor\u00eda de los materiales no toleran bien un gran estiramiento. A medida que se van deformando, intentan volver a su estado relajado inicial – como una goma el\u00e1stica -, pudiendo llegar a romperse cuando la tensi\u00f3n sea muy elevada\u00bb, dice Marino Arroyo, catedr\u00e1tico de la Universitat Polit\u00e8cnica de Catalunya e investigador asociado del IBEC. El equipo descubri\u00f3 que los tejidos epiteliales tienen un comportamiento mec\u00e1nico diferente e inusual. Para su sorpresa, los epitelios no se rompieron durante la deformaci\u00f3n, y recuperaron su tama\u00f1o inicial de manera totalmente reversible al cesar la tensi\u00f3n. Pero lo menos previsible fue ver c\u00f3mo algunas c\u00e9lulas del tejido apenas se deformaban, mientras que otras lo hac\u00edan de forma extrema, aumentando su \u00e1rea m\u00e1s de diez veces.<\/p>\n

Los autores han identificado los mecanismos moleculares que explican este comportamiento f\u00edsico, al que denominan \u00absuperelasticidad activa\u00bb en analog\u00eda con el comportamiento de algunas aleaciones met\u00e1licas de alta tecnolog\u00eda utilizadas en aplicaciones m\u00e9dicas. A medida que el tejido se estira, las c\u00e9lulas que lo componen tienen la habilidad de mantenerse en un estado relajado o bien cambiar hacia un estado s\u00faperdeformado sin que esto les cause ninguna \u201cmolestia\u201d. Como consecuencia, estos tejidos pueden soportar una deformaci\u00f3n creciente gracias a que sus c\u00e9lulas van cambiando progresivamente a su estado s\u00faperdeformado sin aumentar la tensi\u00f3n, lo que de otra forma comprometer\u00eda la integridad o la cohesi\u00f3n del tejido.<\/p>\n

\u00abTodos estamos familiarizados con superh\u00e9roes como Ms. Marvel o Los Incre\u00edbles, que son capaces de deformar sus cuerpos m\u00e1s all\u00e1 de los l\u00edmites humanos. Es divertido pensar que nuestras c\u00e9lulas tambi\u00e9n son s\u00faper deformables. \u00a1Estamos hechos de c\u00e9lulas superhero\u00ednas!\u201d, dice Xavier Trepat, investigador ICREA en el IBEC y profesor asociado en la UB. \u00abEntender este sorprendente comportamiento mec\u00e1nico de los tejidos epiteliales podr\u00eda ayudarnos a desarrollar mejores \u00f3rganos artificiales o nuevas tecnolog\u00edas bi\u00f3nicas como los \u00f3rganos-en-un-chip\u00bb, a\u00f1ade Ernest Latorre, del grupo Integrative Cell and Tissue Dynamics del IBEC y primer autor del estudio.<\/p>\n

—<\/p>\n

Este estudio ha recibido financiaci\u00f3n del Ministerio de Econom\u00eda y Competitividad (FEDER), de la Generalitat de Catalu\u00f1a y del programa CERCA, del\u00a0European\u00a0Research\u00a0Council\u00a0(CoG-616480,\u00a0CoG-681434,\u00a0CoG-617233\u00a0y\u00a0StG-640525), de la\u00a0Comisi\u00f3n\u00a0Europea (proyecto H2020-FETPROACT-01-2016-731957), del\u00a0Instituto\u00a0de\u00a0Salud\u00a0Carlos III, del\u00a0Deutsche\u00a0ForschungGemeinschaft\u00a0y de la Fundaci\u00f3n Obra Social \u201cla Caixa\u201d.<\/address>\n

—<\/p>\n

Article referenciat:<\/strong> <\/em>Ernest Latorre, Sohan Kale, Laura Casares, Manuel Gomez-Gonzalez, Marina Uroz, L\u00e9o Valon, Roshna V. Nair, Elena Garreta, Nuria Montserrat, Ar\u00e1nzazu del Campo, Benoit Ladoux, Marino Arroyo & Xavier Trepat (2018). Active superelasticity in three-dimensional epithelia of controlled shape.<\/a> Nature<\/em>, pub ahead of print<\/p>\n","protected":false},"excerpt":{"rendered":"

\"\"<\/a>Una de las habilidades m\u00e1s envidiables de los superh\u00e9roes es su capacidad para deformar sus cuerpos m\u00e1s all\u00e1 de los l\u00edmites imaginables. <\/h3>\n

En un estudio publicado hoy en la revista Nature<\/em>, cient\u00edficos del IBEC y la UPC han descubierto el mecanismo que explica c\u00f3mo nuestras c\u00e9lulas pueden hacer precisamente eso: deformarse de forma extrema sin romperse.<\/p>\n

La investigaci\u00f3n del IBEC, impulsada por la Fundaci\u00f3n Bancaria \u201cla Caixa\u201d, y la UPC presentan una nueva propiedad f\u00edsica de las c\u00e9lulas, a la que denominan superelasticidad activa, que explica su capacidad inusual para soportar deformaciones extremas.<\/p>\n","protected":false},"author":4,"featured_media":62303,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[97],"tags":[],"post_formats":[],"class_list":["post-62316","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias-de-investigacion"],"yoast_head":"\nInvestigadores descubren c\u00e9lulas superdeformables - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/es\/investigadores-descubren-celulas-superdeformables\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Investigadores descubren c\u00e9lulas superdeformables - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Una de las habilidades m\u00e1s envidiables de los superh\u00e9roes es su capacidad para deformar sus cuerpos m\u00e1s all\u00e1 de los l\u00edmites imaginables. 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