{"id":63570,"date":"2018-12-19T11:26:44","date_gmt":"2018-12-19T10:26:44","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=63570"},"modified":"2020-05-29T20:25:00","modified_gmt":"2020-05-29T18:25:00","slug":"ibec-project-to-defy-blood-brain-barrier-awarded-in-highly-competitive-call","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/es\/ibec-project-to-defy-blood-brain-barrier-awarded-in-highly-competitive-call\/","title":{"rendered":"IBEC project to defy blood-brain barrier awarded in highly competitive call"},"content":{"rendered":"<p>\u201cAccessing the brain is key to study its function and pathology and for diagnostic and therapeutic purposes, but the blood-brain barrier stands in the way,\u201d says ICREA research professor Silvia Muro. \u201cWhen developing drug vehicles \u2013 or cargoes \u2013 most efforts have been devoted to the chemical and engineering aspects. By focusing on their biological regulation instead, we will complement previous knowledge and might be able to optimize these systems so that they can cross the barrier more efficiently.\u201d<\/p>\n<p>One example is the fact that the blood-brain barrier\u2019s cells traffic the very same cargoes arriving from the bloodstream in two directions: into their interior and across their body \u2013 something that has been largely overlooked and whose biological regulation is largely unknown. This could be key to improving drug delivery systems so that they can pass by instead of being absorbed into the blood-brain barrier.<\/p>\n<p>The <a href=\"http:\/\/www.ciencia.gob.es\/stfls\/eSede\/Ficheros\/2018\/Resolucion_Definitiva_Explora_2017.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">\u2018Explora Ciencia\u2019 and \u2018Explora Tecnolog\u00eda\u2019 calls<\/a> have awarded a total of \u20ac5million to projects being carried out in universities and research centers. The grants particularly promote projects which reevaluate established paradigms and seek new concepts or solutions, as well as developing groundbreaking applications in different scientific disciplines.<\/p>\n","protected":false},"excerpt":{"rendered":"<h3><img decoding=\"async\" class=\"left size-full wp-image-55930 lazyload\" data-src=\"http:\/\/www.ibecbarcelona.eu\/wp-content\/uploads\/2017\/11\/silviamuro1.jpg\" alt=\"\" width=\"500\" height=\"369\" data-srcset=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2017\/11\/silviamuro1.jpg 500w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2017\/11\/silviamuro1-300x221.jpg 300w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2017\/11\/silviamuro1-176x130.jpg 176w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2017\/11\/silviamuro1-150x111.jpg 150w\" data-sizes=\"(max-width: 500px) 100vw, 500px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 500px; --smush-placeholder-aspect-ratio: 500\/369;\" \/><\/a>IBEC group leader Silvia Muro has been granted funding in MINECO\u2019s \u2018Explora Ciencia\u2019 and \u2018Explora Tecnolog\u00eda\u2019 2017 call.<\/h3>\n<p>It\u2019s the first competitive grant for Silvia and her group since she joined IBEC at the end of 2017, and one of only 97 research projects to be financed out of the 1594 applications submitted \u2013 a success rate of only 6%.<\/p>\n<p>The project, \u2018Controlling the differential transport of therapeutic cargoes into versus across the BBB (BBB2GATE)\u2019 will aim to develop drug vehicles that can cross the blood-brain barrier using the natural routes that the body\u2019s substances use to circumvent this obstruction.<\/p>\n","protected":false},"author":4,"featured_media":55930,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[24],"tags":[479],"post_formats":[],"class_list":["post-63570","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-institutional-news","tag-silvia-muro"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>IBEC project to defy blood-brain barrier awarded in highly competitive call - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/es\/ibec-project-to-defy-blood-brain-barrier-awarded-in-highly-competitive-call\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"IBEC project to defy blood-brain barrier awarded in highly competitive call - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"IBEC group leader Silvia Muro has been granted funding in MINECO\u2019s \u2018Explora Ciencia\u2019 and \u2018Explora Tecnolog\u00eda\u2019 2017 call.  It\u2019s the first competitive grant for Silvia and her group since she joined IBEC at the end of 2017, and one of only 97 research projects to be financed out of the 1594 applications submitted \u2013 a success rate of only 6%.  The project, \u2018Controlling the differential transport of therapeutic cargoes into versus across the BBB (BBB2GATE)\u2019 will aim to develop drug vehicles that can cross the blood-brain barrier using the natural routes that the body\u2019s substances use to circumvent this obstruction.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ibecbarcelona.eu\/es\/ibec-project-to-defy-blood-brain-barrier-awarded-in-highly-competitive-call\/\" \/>\n<meta property=\"og:site_name\" content=\"Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"article:published_time\" content=\"2018-12-19T10:26:44+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-05-29T18:25:00+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2017\/11\/silviamuro1.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"500\" \/>\n\t<meta property=\"og:image:height\" content=\"369\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"\u00c0ngels L\u00f3pez\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"\u00c0ngels L\u00f3pez\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minuto\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/ibec-project-to-defy-blood-brain-barrier-awarded-in-highly-competitive-call\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/ibec-project-to-defy-blood-brain-barrier-awarded-in-highly-competitive-call\\\/\"},\"author\":{\"name\":\"\u00c0ngels L\u00f3pez\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/person\\\/c212c6b589546130be67986b9290e2b8\"},\"headline\":\"IBEC project to defy blood-brain barrier awarded in highly competitive call\",\"datePublished\":\"2018-12-19T10:26:44+00:00\",\"dateModified\":\"2020-05-29T18:25:00+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/ibec-project-to-defy-blood-brain-barrier-awarded-in-highly-competitive-call\\\/\"},\"wordCount\":203,\"publisher\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/ibec-project-to-defy-blood-brain-barrier-awarded-in-highly-competitive-call\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2017\\\/11\\\/silviamuro1.jpg\",\"keywords\":[\"Silvia Muro\"],\"articleSection\":[\"Institutional news\"],\"inLanguage\":\"es\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/ibec-project-to-defy-blood-brain-barrier-awarded-in-highly-competitive-call\\\/\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/ibec-project-to-defy-blood-brain-barrier-awarded-in-highly-competitive-call\\\/\",\"name\":\"IBEC project to defy blood-brain barrier awarded in highly competitive call - 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