{"id":63684,"date":"2018-11-16T09:50:26","date_gmt":"2018-11-16T08:50:26","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=63684"},"modified":"2020-06-15T13:45:24","modified_gmt":"2020-06-15T11:45:24","slug":"investigadores-del-ibec-revelan-una-estrategia-para-reducir-los-efectos-secundarios-de-la-quimioterapia","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/es\/investigadores-del-ibec-revelan-una-estrategia-para-reducir-los-efectos-secundarios-de-la-quimioterapia\/","title":{"rendered":"Investigadores del IBEC revelan una estrategia para reducir los efectos secundarios de la quimioterapia"},"content":{"rendered":"<p>Una manera de resolverlo ser\u00eda dise\u00f1ar rutas para garantizar que los medicamentos administrados en la quimioterapia s\u00f3lo se activen cuando lleguen al objetivo deseado. Investigadores del grupo de\u00a0<a href=\"https:\/\/ibecbarcelona.eu\/nanoprobes\" target=\"_blank\" rel=\"noopener noreferrer\">Nanoprobes and Nanoswitches group<\/a> del IBEC, que son pioneros en el uso de la luz para activar y desactivar remotamente la acci\u00f3n de los medicamentos y otras mol\u00e9culas, acaban de revelar a la revista JACS que esta posibilidad existe.<\/p>\n<p>En su estudio, los investigadores presentan el fototrexat, una mol\u00e9cula que se puede activar y desactivar remotamente mediante la luz y que act\u00faa como inhibidor del dihidrofolato reductasa (DHFR), una enzima ubicua que tiene un papel esencial en la regulaci\u00f3n de la proliferaci\u00f3n y el crecimiento de las c\u00e9lulas. As\u00ed, el fototrexat se podr\u00eda usar como variante controlada por la luz del metotrexat, un medicamento de amplia prescripci\u00f3n en quimioterapia y utilizado para el tratamiento del c\u00e1ncer y la psoriasi.<\/p>\n<p>El fototrexat se prob\u00f3 en el pez cebra \u2013un organismo modelo que es \u00fatil por su estructura gen\u00e9tica, similar a la del ser humano\u2013 y se demostr\u00f3 que bloquea s\u00f3lidamente la DHFR en su configuraci\u00f3n fotoactivada, pero que queda pr\u00e1cticamente inactivo en su forma oscura o \u201crelajada\u201d.<\/p>\n<p>\u201cEl fototrexat constituye la demostraci\u00f3n conceptual del dise\u00f1o de mol\u00e9culas citot\u00f2xiques reguladas por la luz\u201d, afirma Carlo Matera, investigador del grupo de Nanoprobes and Nanoswitches del IBEC y primer autor del art\u00edculo. \u201cNuestro descubrimiento representa un paso decisivo verso el desarrollo de fotoquimioterapias anti-c\u00e1ncer personalizadas con una eficacia localizada y con reducci\u00f3n de los efectos secundarios.\u201d<\/p>\n<p>&#8212;<br \/>\nCarlo Matera, Alexandre M. J. Gomila, N\u00faria Camarero, Michela Libergoli, Concepci\u00f3 Soler, and Pau Gorostiza (2018). <a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.8b08249\" target=\"_blank\" rel=\"noopener noreferrer\">Photoswitchable Antimetabolite for Targeted Photoactivated Chemotherapy.<\/a> <em>JACS<\/em>, just accepted manuscript<\/p>\n","protected":false},"excerpt":{"rendered":"<h3><img decoding=\"async\" data-src=\"http:\/\/www.ibecbarcelona.eu\/wp-content\/uploads\/2018\/11\/JACSphototrexate_ibec.jpg\" alt=\"\" width=\"810\" height=\"189\" class=\"left size-full wp-image-63371 lazyload\" data-srcset=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2018\/11\/JACSphototrexate_ibec.jpg 810w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2018\/11\/JACSphototrexate_ibec-300x70.jpg 300w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2018\/11\/JACSphototrexate_ibec-768x179.jpg 768w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2018\/11\/JACSphototrexate_ibec-230x54.jpg 230w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2018\/11\/JACSphototrexate_ibec-150x35.jpg 150w\" data-sizes=\"(max-width: 810px) 100vw, 810px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 810px; --smush-placeholder-aspect-ratio: 810\/189;\" \/>Investigadores del IBEC y de IDIBELL han desarrollado una mol\u00e9cula regulada con luz que podr\u00eda mejorar los tratamientos de quimioterapia al controlar la actividad de los agentes anti-c\u00e1ncer.<\/h3>\n<p>La quimioterapia (el uso de agentes citot\u00f3xicos para matar r\u00e1pidamente las c\u00e9lulas que proliferan en los tumores) es una de las armas principales en la lucha contra el c\u00e1ncer. A pesar de esto, su efectividad y la tolerancia del cuerpo a esta t\u00e9cnica a menudo est\u00e1n enormemente limitadas: adem\u00e1s de las \u00e1reas cancerosas, tambi\u00e9n puede afectar \u00e1reas sanas y provocar efectos secundarios.<\/p>\n","protected":false},"author":4,"featured_media":63388,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[97],"tags":[1152],"post_formats":[],"class_list":["post-63684","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias-de-investigacion","tag-pau-gorostiza-es"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Investigadores del IBEC revelan una estrategia para reducir los efectos secundarios de la quimioterapia - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/es\/investigadores-del-ibec-revelan-una-estrategia-para-reducir-los-efectos-secundarios-de-la-quimioterapia\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Investigadores del IBEC revelan una estrategia para reducir los efectos secundarios de la quimioterapia - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Investigadores del IBEC y de IDIBELL han desarrollado una mol\u00e9cula regulada con luz que podr\u00eda mejorar los tratamientos de quimioterapia al controlar la actividad de los agentes anti-c\u00e1ncer.  La quimioterapia (el uso de agentes citot\u00f3xicos para matar r\u00e1pidamente las c\u00e9lulas que proliferan en los tumores) es una de las armas principales en la lucha contra el c\u00e1ncer. A pesar de esto, su efectividad y la tolerancia del cuerpo a esta t\u00e9cnica a menudo est\u00e1n enormemente limitadas: adem\u00e1s de las \u00e1reas cancerosas, tambi\u00e9n puede afectar \u00e1reas sanas y provocar efectos secundarios.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ibecbarcelona.eu\/es\/investigadores-del-ibec-revelan-una-estrategia-para-reducir-los-efectos-secundarios-de-la-quimioterapia\/\" \/>\n<meta property=\"og:site_name\" content=\"Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"article:published_time\" content=\"2018-11-16T08:50:26+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-06-15T11:45:24+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2018\/11\/JACSphototrexate_ibec_clipped.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"400\" \/>\n\t<meta property=\"og:image:height\" content=\"309\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"\u00c0ngels L\u00f3pez\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"\u00c0ngels L\u00f3pez\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/investigadores-del-ibec-revelan-una-estrategia-para-reducir-los-efectos-secundarios-de-la-quimioterapia\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/investigadores-del-ibec-revelan-una-estrategia-para-reducir-los-efectos-secundarios-de-la-quimioterapia\\\/\"},\"author\":{\"name\":\"\u00c0ngels L\u00f3pez\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/person\\\/c212c6b589546130be67986b9290e2b8\"},\"headline\":\"Investigadores del IBEC revelan una estrategia para reducir los efectos secundarios de la quimioterapia\",\"datePublished\":\"2018-11-16T08:50:26+00:00\",\"dateModified\":\"2020-06-15T11:45:24+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/investigadores-del-ibec-revelan-una-estrategia-para-reducir-los-efectos-secundarios-de-la-quimioterapia\\\/\"},\"wordCount\":315,\"publisher\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/investigadores-del-ibec-revelan-una-estrategia-para-reducir-los-efectos-secundarios-de-la-quimioterapia\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2018\\\/11\\\/JACSphototrexate_ibec_clipped.jpg\",\"keywords\":[\"Pau Gorostiza\"],\"articleSection\":[\"Noticias de investigaci\u00f3n\"],\"inLanguage\":\"es\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/investigadores-del-ibec-revelan-una-estrategia-para-reducir-los-efectos-secundarios-de-la-quimioterapia\\\/\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/investigadores-del-ibec-revelan-una-estrategia-para-reducir-los-efectos-secundarios-de-la-quimioterapia\\\/\",\"name\":\"Investigadores del IBEC revelan una estrategia para reducir los efectos secundarios de la quimioterapia - 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