{"id":64462,"date":"2018-12-24T11:35:25","date_gmt":"2018-12-24T10:35:25","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/two-promising-avenues-in-the-fight-against-antibiotic-resistance\/"},"modified":"2020-06-15T13:06:08","modified_gmt":"2020-06-15T11:06:08","slug":"two-promising-avenues-in-the-fight-against-antibiotic-resistance","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/es\/two-promising-avenues-in-the-fight-against-antibiotic-resistance\/","title":{"rendered":"Dos v\u00edas prometedoras en la lucha contra la resistencia a los antibi\u00f3ticos"},"content":{"rendered":"

sino que ahora se a\u00f1ade un problema m\u00e9dico altamente urgente: el r\u00e1pido aumento de las llamados \u201csuperbacterias\u201d o bacterias multiresistentes, que son inmunes a pr\u00e1cticamente todos los antibi\u00f3ticos que tenemos actualmente a nuestro alcance.<\/p>\n

Grupos de investigaci\u00f3n como el de Eduard Torrents<\/a>, subvencionado parcialmente por becas de la Obra Social \u201cla Caixa\u201d, est\u00e1n trabajando en varios m\u00e9todos para superar la resistencia de las bacterias, como por ejemplo desarrollando nuevos medicamentos dirigidos a nuevas dianas o bien intefiriendo en los plasmidios que otorgan la resistencia contra los antibi\u00f3ticos actuales.<\/p>\n

En una publicaci\u00f3n en la revista ACS Omega<\/em>, con colaboradores de la UB, la UAB y la Universidad de\u00a0Kwazulu-Natal\u00a0de Sur\u00e1frica, el grupo ha\u00a0desvelado que los derivados de la\u00a0hidroxilamina podr\u00edan convertirse en unos nuevos y prometedores agentes en la lucha contra las bacterias pat\u00f3genas resistentes a los f\u00e1rmacos. Los compuestos, conocidos como N-HA (compuestos N-sustituidos de\u00a0hidroxilamina, un h\u00edbrido de amon\u00edaco y agua), se pueden concebir y sintetizar con actividad\u00a0antibacteriana. Despu\u00e9s, pueden actuar como \u201ccarro\u00f1eros radicales\u201d para inhibir la ribonucle\u00f3tido\u00a0reductasa\u00a0(RNR), una enzima bacteriana que es esencial para la proliferaci\u00f3n de las bacterias durante una infecci\u00f3n, porque proporciona el pilar fundamental para la s\u00edntesis y la reparaci\u00f3n del ADN. Esta enzima se podr\u00eda considerar como un nuevo objetivo\u00a0antibacterino a la hora de tratar las infecciones por bacterias.<\/p>\n

El trabajo ha demostrado la poca toxicidad de los compuestos en el hu\u00e9sped y el efecto antimicrobiano contra varias bacterias y ha probado que reduc\u00edan la masa de un\u00a0biofilm determinado (el entorno en el cual las bacterias pueden crecer y adaptarse, de forma que se crean las condiciones adecuadas para una infecci\u00f3n) en bacterias causantes de dolencias, incluidos la\u00a0Pseudomonas\u00a0aeruginosa<\/em>, la\u00a0Staphylococcus\u00a0aureus<\/em>\u00a0y la Escherichia coli<\/em>.<\/p>\n

El segundo estudio, publicado en la revista de alto impacto\u00a0Journal\u00a0of\u00a0Medicinal\u00a0Chemistry\u00a0<\/em>con colaboradores de Austria, Nueva Zelanda, Hungr\u00eda, Serbia, Singapur y la Rep\u00fablica Eslovaca, describe otro agente prometedor que tambi\u00e9n podr\u00eda presentar propiedades\u00a0anticancer\u00edgenas.<\/p>\n

Se sabe que la\u00a0morfolina\u00a0ha mostrado acci\u00f3n\u00a0anticancer\u00edgena\u00a0(se utiliza en varios medicamentos comercializados) y los investigadores han sintetizado h\u00edbridos de\u00a0morfolina-tiosemicarbazona\u00a0y complejos de cobre(II) soluble en agua que han proporcionado un claro efecto\u00a0antibacteriano, al inhibir el\u00a0RNR\u00a0a trav\u00e9s de un proceso conocido como\u00a0quelaci\u00f3n del hierro intracelular. Estos compuestos con propiedades\u00a0anticancer\u00edgenas\u00a0y\u00a0antibacterianas ofrecen el doble beneficio de afectar simult\u00e1neamente la malignidad del c\u00e1ncer a la vez que disminuyen el riesgo de infecci\u00f3n bacteriana, que puede ser a menudo una causa de muerte en pacientes de c\u00e1ncer\u00a0immunocomprometidos.<\/p>\n

\u201cLa emergencia y la creciente prevalencia de las cepas bacterianas que son resistentes a los antibi\u00f3ticos disponibles exigen que se descubran planteamientos terap\u00e9uticos como estos\u201d, declara Eduard. \u201cTenemos que hacer todo lo que podamos ahora para retrasar el d\u00eda en que pueda ser demasiado peligroso llevar a cabo procedimientos cl\u00ednicos como los trasplantes de \u00f3rganos, la quimioterapia o la cura de ni\u00f1os prematuros.\u201d<\/p>\n

—<\/p>\n

Laia Miret-Casals, Aida Baelo, Esther Juli\u00e1n, Josep Astola, Ariadna Lobo-Ruiz, Fernando Albericio, and Eduard Torrents (2018). Hydroxylamine Derivatives as a New Paradigm in the Search of Antibacterial Agents. <\/a>ACS Omega<\/em> 3 (12), pp 17057\u201317069<\/p>\n

Kateryna Ohui, Eleonora Afanasenko, Felix Bacher, Rachel Lim Xue Ting, Ayesha Zafar, Nuria Blanco-Cabra, Eduard Torrents, Orsolya Domotor, Nora V. May, Denisa Darvasiova, Eva A Enyedy, Ana D. Popovi\u0107-Bijeli\u0107, Johannes Reynisson, Peter Rapta, Maria Babak, Giorgia Pastorin, and Vladimir B. Arion (2018).Hydroxylamine Derivatives as a New Paradigm in the Search of Antibacterial Agents. <\/a> New Water-Soluble Copper(II) Complexes with Morpholine-Thiosemicarbazone Hybrids: Insights into the Anticancer and Antibacterial Mode of Action. J. Med. Chem.<\/em>, Just Accepted Manuscript<\/p>\n","protected":false},"excerpt":{"rendered":"

\"\"El grupo Infecciones bacterianas: terapias antimicrobianas del IBEC ha publicado dos art\u00edculos en los que ofrece nuevas esperanzas para la investigaci\u00f3n urgente de antimicrobianos.<\/h3>\n

\u201cNecesitamos antimicrobianos desesperadamente\u201d, afirma el investigador principal del grupo, Eduard Torrents. \u201cLa resistencia a los antibi\u00f3ticos es una de las amenazas actuales m\u00e1s importantes para la salud humana, y ya se acerca el momento en que toda una serie de procedimientos rutinarios pueden volverse mucho m\u00e1s arriesgados\u00bb. <\/p>\n

No solo algunas infecciones o dolencias comunes se han vuelto resistentes a los antibi\u00f3ticos que habitualmente se usaban para tratarlas, <\/p>\n","protected":false},"author":4,"featured_media":64318,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[97],"tags":[1142],"post_formats":[],"class_list":["post-64462","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias-de-investigacion","tag-eduard-torrents-es"],"yoast_head":"\nDos v\u00edas prometedoras en la lucha contra la resistencia a los antibi\u00f3ticos - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/es\/two-promising-avenues-in-the-fight-against-antibiotic-resistance\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Dos v\u00edas prometedoras en la lucha contra la resistencia a los antibi\u00f3ticos - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"El grupo Infecciones bacterianas: terapias antimicrobianas del IBEC ha publicado dos art\u00edculos en los que ofrece nuevas esperanzas para la investigaci\u00f3n urgente de antimicrobianos. \u201cNecesitamos antimicrobianos desesperadamente\u201d, afirma el investigador principal del grupo, Eduard Torrents. \u201cLa resistencia a los antibi\u00f3ticos es una de las amenazas actuales m\u00e1s importantes para la salud humana, y ya se acerca el momento en que toda una serie de procedimientos rutinarios pueden volverse mucho m\u00e1s arriesgados". 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