{"id":6544,"date":"2012-07-11T08:43:11","date_gmt":"2012-07-11T08:43:11","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/new\/qfichandoq-objetos-y-virus-a-la-nanoescala\/"},"modified":"2015-01-07T13:50:05","modified_gmt":"2015-01-07T13:50:05","slug":"qfichandoq-objetos-y-virus-a-la-nanoescala","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/es\/qfichandoq-objetos-y-virus-a-la-nanoescala\/","title":{"rendered":"\u00abFichando\u00bb objetos y virus a la nanoescala"},"content":{"rendered":"

En su art\u00edculo \u00abLabel-free identification of single dielectric nanoparticles and viruses with ultraweak polarization forces\u00bb, Laura Fumagalli, el responsable del grupo Gabriel Gomila y sus compa\u00f1eros presentan su trabajo en una nueva t\u00e9cnica para identificar nano-objetos como virus sin necesidad de etiquetado, lo que podr\u00eda ser un gran avance para el diagn\u00f3stico biom\u00e9dico, la protecci\u00f3n del medio ambiente y la nanoelectr\u00f3nica.<\/p>\n

El grupo ha superado las limitaciones que existen actualmente en la identificaci\u00f3n y caracterizaci\u00f3n basadas en la EFM midiendo la constante diel\u00e9ctrica, o permitividad, de los objetos. Esto da una indicaci\u00f3n de c\u00f3mo reacciona el material del que est\u00e1 hecho un objeto a la aplicaci\u00f3n de un campo el\u00e9ctrico. Al aumentar la resoluci\u00f3n el\u00e9ctrica del microscopio en casi dos \u00f3rdenes de magnitud, pudieron detectar fuerzas ultrad\u00e9biles, y al usar nano-puntas geom\u00e9tricamente estables, adem\u00e1s de un m\u00e9todo preciso de modelizar sus resultados que tiene en cuenta la f\u00edsica de un sistema y todos sus elementos geom\u00e9tricos, fueron capaces de cuantificar con precisi\u00f3n las constantes diel\u00e9ctricas, y de usarlas a modo de \u00abhuellas dactilares\u00bb. Esto les permiti\u00f3 distinguir objetos con forma id\u00e9ntica pero diferente composici\u00f3n, que ser\u00edan imposibles de reconocer sin etiquetar.<\/p>\n

\u201cAnteriormente, la EFM s\u00f3lo pod\u00eda distinguir entre nanoobjetos met\u00e1licos y no met\u00e1licos en experimentos en blanco y negro,\u201d explica Laura, autora principal del estudio. \u201cAhora hemos reconocido cuantitativamente aquellos de materiales muy similares y con constantes diel\u00e9ctricas bajas, como es el caso de muchos complejos biol\u00f3gicos.\u201d<\/p>\n

\u201cNuestro m\u00e9todo, que proporciona una forma no invasiva de determinar el estado interno de los objetos y de correlacionarlos con sus funciones sin tenerlos que cortar o etiquetar, ser\u00e1 una herramienta valios\u00edsima para diversas \u00e1reas de la investigaci\u00f3n cient\u00edfica,\u201d dice Gabriel Gomila, coautor del estudio y responsable del grupo de investigaci\u00f3n del IBEC. \u201cEs especialmente importante en la nanomedicina para diagn\u00f3sticos biom\u00e9dicos, pues abre la puerta a la detecci\u00f3n cuantitativa sin etiquetas de macromol\u00e9culas biol\u00f3gicas como los virus, bas\u00e1ndose en sus propiedades diel\u00e9ctricas.\u201d <\/p>\n

Los investigadores han aplicado su t\u00e9cnica a importantes complejos biol\u00f3gicos, como los virus. Al desentra\u00f1ar por primera vez las propiedades diel\u00e9ctricas de estos nanoobjetos, que hasta ahora hab\u00edan sido inaccesibles, podr\u00edan descubrir importantes aspectos de la funcionalidad de un virus. Con su t\u00e9cnica, distinguieron entre virus vac\u00edos y portadores de ADN, por ejemplo, que son los que pueden insertar su material gen\u00e9tico en el ADN de una c\u00e9lula hu\u00e9sped.<\/p>\n

\u201cEstos resultados son tambi\u00e9n un gran avance en el estudio fundamental de los materiales diel\u00e9ctricos a la nanoescala, que aportan los bloques de construcci\u00f3n que determinan el rendimiento de la nueva generaci\u00f3n de dispositivos nanoelectr\u00f3nicos disponible hoy en d\u00eda,\u201d a\u00f1ade Laura. \u201cNuestra nueva t\u00e9cnica arrojar\u00e1 luz sobre cuestiones como las propiedades diel\u00e9ctricas de nanocompuestos y nanodispositivos h\u00edbridos desarrollados recientemente, y nos dir\u00e1 cu\u00e1l es la escala m\u00e1s peque\u00f1a en la cual un objeto diel\u00e9ctrico puede conservar sus propiedades \u2013 en otras palabras, hasta d\u00f3nde podemos reducir.\u201d<\/p>\n

Para leer el art\u00edculo, consultad la web de Nature Materials<\/em> aqu\u00ed<\/a>. <\/p>\n

—<\/p>\n

Cobertura en los medios:<\/p>\n

http:\/\/www.lswn.it\/comunicati\/stampa\/2012\/riconoscimento_nano_oggetti_e_virus_senza_marcatori<\/a><\/p>\n

http:\/\/www.sciencedaily.com\/releases\/2012\/07\/120709093046.htm<\/a><\/p>\n

http:\/\/phys.org\/news\/2012-07-scientists-fingerprint-nanoscale-viruses.html<\/a><\/p>\n

http:\/\/www.teinteresa.es\/salud\/Investigadores-espanoles-descubren-celulas-empujones_0_733727017.html<\/a><\/p>\n

http:\/\/www.nanowerk.com\/news2\/newsid=25853.php<\/a><\/p>\n

http:\/\/www.stonehearthnewsletters.com\/virus-detection-technologies-get-even-smaller-which-is-a-good-thing\/infectious-diseases\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

El grupo de Caracterizaci\u00f3n Bioel\u00e9ctrica a la Nanoescala del IBEC celebra esta semana la publicaci\u00f3n de sus \u00faltimos resultados en la revista Nature Materials<\/em>.<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[97],"tags":[],"post_formats":[],"class_list":["post-6544","post","type-post","status-publish","format-standard","hentry","category-noticias-de-investigacion"],"yoast_head":"\n"Fichando" objetos y virus a la nanoescala - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/es\/qfichandoq-objetos-y-virus-a-la-nanoescala\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\""Fichando" objetos y virus a la nanoescala - 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