{"id":6556,"date":"2012-07-12T15:34:37","date_gmt":"2012-07-12T15:34:37","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/new\/descubierto-un-nuevo-tipo-de-ola-en-tejidos-vivos\/"},"modified":"2015-01-07T13:42:55","modified_gmt":"2015-01-07T13:42:55","slug":"descubierto-un-nuevo-tipo-de-ola-en-tejidos-vivos","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/es\/descubierto-un-nuevo-tipo-de-ola-en-tejidos-vivos\/","title":{"rendered":"Descubierto un nuevo tipo de ola en tejidos vivos"},"content":{"rendered":"

Al estudiar el movimiento de racimos de c\u00e9lulas, los cient\u00edficos hallaron pruebas de la aparici\u00f3n de crestas de deformaci\u00f3n similares a olas, lanzadas a los bordes de los racimos y que se propagan de c\u00e9lula a c\u00e9lula a aproximadamente el doble de la velocidad con que las c\u00e9lulas se mov\u00edan.<\/p>\n

\u201cImagina ver un atasco de tr\u00e1fico desde arriba,\u201d dice el responsable del grupo, Xavier Trepat, cuyo trabajo aparece tambi\u00e9n como investigaci\u00f3n destacada en Nature<\/em>. \u201cVer\u00e1s un efecto de oleaje similar cuando algunos coches avanzan y otros los siguen despu\u00e9s de un ligero retraso para llenar los huecos. Pero a diferencia de los coches, las c\u00e9lulas de nuestro estudio pueden empujar y estirar las unas a las otras, as\u00ed que el fen\u00f3meno es mucho m\u00e1s intenso.\u201d<\/p>\n

Hace mucho que se sabe c\u00f3mo funcionan las ondas mec\u00e1nicas en la materia inerte, pero \u00e9sta es la primera vez que se observan en materia viva. \u201cEstas oleadas avanzan a aproximadamente un mil\u00edmetro por d\u00eda, y est\u00e1n entre las ondas m\u00e1s lentas jam\u00e1s descubiertas,\u201d a\u00f1ade Xavier.<\/p>\n

Los descubrimientos del grupo establecen un patr\u00f3n de estr\u00e9s y tensi\u00f3n reiterados en el tiempo y el espacio a lo largo de un tejido multicelular, algo que jam\u00e1s se hab\u00eda observado antes, y que es un probable candidato a ser la fuerza impulsora tras la activaci\u00f3n de las redes responsables de la invasi\u00f3n celular t\u00edpica del c\u00e1ncer. \u201cEs sabido que las fuerzas f\u00edsicas pueden actuar como se\u00f1ales intracelulares para activar redes locales de prote\u00ednas reguladoras \u2013 los procesos necesarios para que sucedan los eventos biol\u00f3gicos, sean buenos o malos,\u201d dice Xavier. \u201cAs\u00ed pues, nuestra \u201cola\u201d reci\u00e9n descubierta podr\u00eda jugar un papel primordial en provocar las v\u00edas requeridas.\u201d<\/p>\n

Con estos \u00faltimos resultados, los cient\u00edficos est\u00e1n un paso m\u00e1s cerca de comprender c\u00f3mo migran las c\u00e9lulas, y una etapa m\u00e1s cerca de comprender las din\u00e1micas de las c\u00e9lulas tumorales y los mecanismos f\u00edsicos que usan para separarse y metastatizar. <\/p>\n

Imagen: Olas de estiramiento celular (en rosa) se propagan de c\u00e9lula en c\u00e9lula a lo largo de una una monocapa en migraci\u00f3n.<\/p>\n

—<\/p>\n

Serra-Picamal, X.<\/a>, Conte, V.<\/a>, Vincent, R.<\/a>, A\u00f1\u00f3n, E.<\/a>, Tambe, D., Bazelli\u00e8res, E.<\/a>, Butler, J., Fredberg, J. & Trepat, X<\/a>. (2012). Mechanical waves during tissue expansion<\/a><\/strong>. Nature Physics.<\/p>\n","protected":false},"excerpt":{"rendered":"

El grupo de Din\u00e1micas Interactivas Celulares y Tisulares ha publicado en la revista Nature Physics<\/em> los \u00faltimos resultados que han obtenido en su b\u00fasqueda de c\u00f3mo comprender la migraci\u00f3n colectiva de las c\u00e9lulas de nuestro cuerpo.<\/p>\n","protected":false},"author":4,"featured_media":6533,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[97],"tags":[],"post_formats":[],"class_list":["post-6556","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias-de-investigacion"],"yoast_head":"\nDescubierto un nuevo tipo de ola en tejidos vivos - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/es\/descubierto-un-nuevo-tipo-de-ola-en-tejidos-vivos\/\" 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