{"id":65653,"date":"2019-02-18T19:49:06","date_gmt":"2019-02-18T18:49:06","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=65653"},"modified":"2020-06-15T13:03:40","modified_gmt":"2020-06-15T11:03:40","slug":"investigadores-del-ibec-generan-minirrinones-vascularizados-a-partir-de-celulas-madre-humanas","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/es\/investigadores-del-ibec-generan-minirrinones-vascularizados-a-partir-de-celulas-madre-humanas\/","title":{"rendered":"Investigadores del IBEC generan minirri\u00f1ones vascularizados a partir de c\u00e9lulas madre humanas"},"content":{"rendered":"<p>de gestaci\u00f3n, y muestra c\u00f3mo estos cultivos tridimensionales mimetizan aspectos fundamentales durante la formaci\u00f3n del ri\u00f1\u00f3n, como la distribuci\u00f3n, la funcionalidad y la organizaci\u00f3n espec\u00edfica de las c\u00e9lulas.<\/p>\n<p>La investigaci\u00f3n, liderada por la Dra. N\u00faria Montserrat, investigadora principal ICREA en el IBEC, y en el que tambi\u00e9n han colaborado el Hospital Cl\u00ednic de Barcelona, el Consejo Superior de Investigaciones Cient\u00edficas, la Universidad de Barcelona y el Salk Institute for Biological Studies en los EE.UU, permite generar conocimiento fundamental sobre c\u00f3mo se desarrolla este \u00f3rgano y, a su vez, facilita el dise\u00f1o de experimentos focalizados en el cribaje de compuestos terap\u00e9uticos destinados a la regeneraci\u00f3n renal.<\/p>\n<p>Para llevar a cabo este proceso, los investigadores han utilizado c\u00e9lulas madre pluripotentes, con las que han conseguido recapitular el desarrollo embrionario del ri\u00f1\u00f3n \u2013hasta el segundo trimestre de gestaci\u00f3n-, y han generado los minirri\u00f1ones simulando la dureza del microambiente embrionario mediante el uso de biomateriales.<\/p>\n<figure id=\"attachment_65624\" aria-describedby=\"caption-attachment-65624\" style=\"width: 390px\" class=\"wp-caption alignright\"><img decoding=\"async\" class=\"wp-image-65624 lazyload\" data-src=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2019\/02\/minirrin\u0303o\u0301n-ibec.png\" alt=\"\" width=\"400\" height=\"400\" data-srcset=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2019\/02\/minirrin\u0303o\u0301n-ibec.png 470w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2019\/02\/minirrin\u0303o\u0301n-ibec-150x150.png 150w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2019\/02\/minirrin\u0303o\u0301n-ibec-300x300.png 300w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2019\/02\/minirrin\u0303o\u0301n-ibec-130x130.png 130w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2019\/02\/minirrin\u0303o\u0301n-ibec-45x45.png 45w\" data-sizes=\"(max-width: 400px) 100vw, 400px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 400px; --smush-placeholder-aspect-ratio: 400\/400;\" \/><figcaption id=\"caption-attachment-65624\" class=\"wp-caption-text\">Miniri\u00f1\u00f3n derivado a partir de c\u00e9lulas madre pluripotentes humanas<\/figcaption><\/figure>\n<p>\u201cUno de los aspectos cruciales en la investigaci\u00f3n con organoides consiste en desarrollar una metodolog\u00eda que permita su maduraci\u00f3n en una placa de cultivo, y que estos se asemejen al \u00f3rgano adulto, por ello es esencial proveer a estos mini\u00f3rganos, entre otras cosas, de una red vascular, esencial para facilitar el intercambio de nutrientes y asegurar su funcionalidad\u201d, comenta N\u00faria Montserrat.<\/p>\n<p>Para superar este obst\u00e1culo, los investigadores han implantado los minirri\u00f1ones en la vasculatura embrionaria del pollo y han observado que, despu\u00e9s de pocos d\u00edas, los minirri\u00f1ones presentaban c\u00e9lulas endoteliales y evidencias estructurales que indicaban una mejor diferenciaci\u00f3n dentro de estas estructuras tridimensionales.<\/p>\n<p>Este tipo de abordaje representa una estrategia prometedora para el desarrollo de tejidos biofuncionales, que puedan ser utilizados tanto para la detecci\u00f3n de drogas como para el desarrollo de medicina personalizada. \u00abAnticipamos que este procedimiento que presentamos puede ser aplicado de inmediato en los laboratorios que trabajen en el modelado de enfermedades del ri\u00f1\u00f3n\u00bb, comenta Nuria Montserrat. \u201cNecesitamos entender c\u00f3mo se generan los tejidos para poder abordar cuestiones relacionadas con su disfunci\u00f3n\u201d, a\u00f1ade el Dr. Josep M. Campistol del Hospital Cl\u00ednic de Barcelona.<\/p>\n<p>El estudio en el que han participado investigadores de tres grupos de investigaci\u00f3n de IBEC, el Hospital Cl\u00ednic en Barcelona, el Consejo Superior de Investigaciones, la Universidad de Barcelona y el Salk Institute for Biological Studies en los EE.UU., ha sido financiado parcialmente por el European Research Council y la Asociaci\u00f3n Espa\u00f1ola contra el c\u00e1ncer, entre otras instituciones.<\/p>\n<hr \/>\n<p><em><strong>Source article:\u00a0<\/strong>Garreta, Elena, Prado, Patricia, Tarantino, Carolina, Oria, Roger, Fanlo, Lucia, Mart\u00ed, Elisa, Zalvidea, Dobryna, Trepat, Xavier, Roca-Cusachs, Pere, Gavald\u00e0\u00a0-Navarro, Aleix, Cozzuto, Luca, Campistol, Josep M., Izpis\u00faa Belmonte, Juan Carlos, Hurtado del Pozo, Carmen, Montserrat, Nuria, (2018).\u00a0<a href=\"https:\/\/doi.org\/10.1038\/s41563-019-0287-6\" target=\"_blank\" rel=\"noopener noreferrer\">Fine tuning the extracellular environment accelerates the derivation of kidney organoids from human pluripotent stem cells.\u00a0<\/a><i>Nature Materials\u00a0<\/i>Ahead<\/em><\/p>\n<hr \/>\n<hr \/>\n<p>Algunas apariciones en prensa escrita:<\/p>\n<ul>\n<li><a href=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2019\/02\/0021OG4Y_Ibec_Creen-ronyons-artificials-amb-reg-sanguini.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">Creen ronyons artificials amb reg sanguini<\/a> &#8211; El Punt Avui<\/li>\n<li><a href=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2019\/02\/0021OGH8_Ibec_Microronyons-al-laboratori-un-\u00e8xit-esperan\u00e7ador.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">Microronyons al laboratori, un \u00e8xit esperan\u00e7ador<\/a> &#8211; Diari Ara<\/li>\n<li><a href=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2019\/02\/0021OH74_Montserrat_Crean-en-solo-20-d\u00edas-minirri\u00f1ones-a-partir-de-c\u00e9lulas-madre.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">Crean en s\u00f3lo 20 d\u00edas miniri\u00f1ones a partir de c\u00e9lulas madre<\/a> &#8211; Abc<\/li>\n<li><a href=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2019\/02\/0021OIT7_Ibec_Investigadores-catalanes-crean-minirri\u00f1ones-con-c\u00e9lulas-madre.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">Investigadores catalanes crean miniri\u00f1ones con c\u00e9lulas madre<\/a> &#8211; El Peri\u00f3dico<\/li>\n<li><a href=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2019\/02\/0021P16T_Ibec_La-ciencia-crea-minirri\u00f1ones-parecidos-a-los-de-un-feto-de-6-meses-con-c\u00e9lulas-madre.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">La ciencia crea miniri\u00f1ones parecidos a los de un feto de 6 meses con c\u00e9lulas madre<\/a> &#8211; La Raz\u00f3n<\/li>\n<\/ul>\n<p><a href=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2019\/02\/prensa-escrita.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">Dossier de prensa escrita completo<\/a><\/p>\n<p>Apariciones en radio:<\/p>\n<ul>\n<li><a href=\"https:\/\/www.ccma.cat\/catradio\/alacarta\/catalunya-vespre\/creen-amb-cellules-mare-minironyons-similars-als-del-segon-trimestre-de-gestacio\/audio\/1030573\/\" target=\"_blank\" rel=\"noopener noreferrer\">Catalunya R\u00e0dio\u00a0<\/a><\/li>\n<li>Onda Cero &#8211; <a href=\"https:\/\/www.ondacero.es\/programas\/julia-en-la-onda\/audios-podcast\/mesa-redaccion\/cientificos-consiguen-crear-en-20-dias-minirrinones-a-partir-de-celulas-madre_201902195c6c22380cf2717239dce1bc.html\" target=\"_blank\" rel=\"noopener noreferrer\">Julia en la Onda<\/a><\/li>\n<li>Onda Cero &#8211; <a href=\"https:\/\/www.ondacero.es\/emisoras\/catalunya\/audios-podcast\/nits-radio\/creacio-de-miniorgans-en-laboratori-a-casa-nostra_201902275c763f410cf252a9eda8bb4a.html\" target=\"_blank\" rel=\"noopener noreferrer\">Nits de r\u00e0dio amb Carles Lamelo<\/a><\/li>\n<li>La COPE &#8211; <a href=\"https:\/\/www.cope.es\/programas\/la-linterna\/horas-completas\" target=\"_blank\" rel=\"noopener noreferrer\">La Linterna\u00a0<\/a><\/li>\n<\/ul>\n<p>Apariciones en TV:<\/p>\n<ul>\n<li><a href=\"https:\/\/beteve.cat\/terricoles\/nuria-montserrat\/\" target=\"_blank\" rel=\"noopener noreferrer\">Betev\u00e9<\/a><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<h3><img decoding=\"async\" class=\"left size-medium wp-image-64079 lazyload\" data-src=\"http:\/\/www.ibecbarcelona.eu\/wp-content\/uploads\/2019\/02\/nuriamontserrat_grupo_web-1.jpg\" alt=\"\" width=\"500\" height=\"\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" \/>Investigadores del IBEC han creado por primera vez cultivos tridimensionales -organoides-  a partir de c\u00e9lulas madre pluripotentes, que se asemejan a tejido embrionario de ri\u00f1\u00f3n humano durante el segundo trimestre de gestaci\u00f3n.<\/h3>\n<p>Mediante el uso de biomateriales que mimetizan el microambiente embrionario los investigadores tambi\u00e9n han logrado que estos minirri\u00f1ones presenten caracter\u00edsticas relevantes para su uso inmediato en el modelado de patolog\u00edas renales.<br \/>\nEn un estudio publicado ayer en la revista Nature Materials se describe c\u00f3mo investigadores del IBEC han generado organoides, o mini\u00f3rganos, que se asemejan al ri\u00f1\u00f3n embrionario humano durante el segundo trimestre <\/p>\n","protected":false},"author":4,"featured_media":65633,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[97],"tags":[1124],"post_formats":[],"class_list":["post-65653","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias-de-investigacion","tag-nuria-montserrat-es-2"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Investigadores del IBEC generan minirri\u00f1ones vascularizados a partir de c\u00e9lulas madre humanas - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/es\/investigadores-del-ibec-generan-minirrinones-vascularizados-a-partir-de-celulas-madre-humanas\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Investigadores del IBEC generan minirri\u00f1ones vascularizados a partir de c\u00e9lulas madre humanas - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Investigadores del IBEC han creado por primera vez cultivos tridimensionales -organoides- a partir de c\u00e9lulas madre pluripotentes, que se asemejan a tejido embrionario de ri\u00f1\u00f3n humano durante el segundo trimestre de gestaci\u00f3n.Mediante el uso de biomateriales que mimetizan el microambiente embrionario los investigadores tambi\u00e9n han logrado que estos minirri\u00f1ones presenten caracter\u00edsticas relevantes para su uso inmediato en el modelado de patolog\u00edas renales. En un estudio publicado ayer en la revista Nature Materials se describe c\u00f3mo investigadores del IBEC han generado organoides, o mini\u00f3rganos, que se asemejan al ri\u00f1\u00f3n embrionario humano durante el segundo trimestre\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ibecbarcelona.eu\/es\/investigadores-del-ibec-generan-minirrinones-vascularizados-a-partir-de-celulas-madre-humanas\/\" \/>\n<meta property=\"og:site_name\" content=\"Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"article:published_time\" content=\"2019-02-18T18:49:06+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-06-15T11:03:40+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2019\/02\/nuriamontserrat_grupo_web-1.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"500\" \/>\n\t<meta property=\"og:image:height\" content=\"338\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"\u00c0ngels L\u00f3pez\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"\u00c0ngels L\u00f3pez\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/investigadores-del-ibec-generan-minirrinones-vascularizados-a-partir-de-celulas-madre-humanas\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/investigadores-del-ibec-generan-minirrinones-vascularizados-a-partir-de-celulas-madre-humanas\\\/\"},\"author\":{\"name\":\"\u00c0ngels L\u00f3pez\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/person\\\/c212c6b589546130be67986b9290e2b8\"},\"headline\":\"Investigadores del IBEC generan minirri\u00f1ones vascularizados a partir de c\u00e9lulas madre humanas\",\"datePublished\":\"2019-02-18T18:49:06+00:00\",\"dateModified\":\"2020-06-15T11:03:40+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/investigadores-del-ibec-generan-minirrinones-vascularizados-a-partir-de-celulas-madre-humanas\\\/\"},\"wordCount\":643,\"publisher\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/investigadores-del-ibec-generan-minirrinones-vascularizados-a-partir-de-celulas-madre-humanas\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2019\\\/02\\\/nuriamontserrat_grupo_web-1.jpg\",\"keywords\":[\"Nuria Montserrat\"],\"articleSection\":[\"Noticias de investigaci\u00f3n\"],\"inLanguage\":\"es\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/investigadores-del-ibec-generan-minirrinones-vascularizados-a-partir-de-celulas-madre-humanas\\\/\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/investigadores-del-ibec-generan-minirrinones-vascularizados-a-partir-de-celulas-madre-humanas\\\/\",\"name\":\"Investigadores del IBEC generan minirri\u00f1ones vascularizados a partir de c\u00e9lulas madre humanas - 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