{"id":6571,"date":"2012-07-25T10:02:14","date_gmt":"2012-07-25T10:02:14","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/new\/un-biomaterial-inteligente-favorece-la-angiogenesis\/"},"modified":"2015-01-07T13:05:13","modified_gmt":"2015-01-07T13:05:13","slug":"un-biomaterial-inteligente-favorece-la-angiogenesis","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/es\/un-biomaterial-inteligente-favorece-la-angiogenesis\/","title":{"rendered":"Un biomaterial inteligente favorece la angiog\u00e9nesis"},"content":{"rendered":"

Investigadores del grupo de Josep Planell, Biomateriales para Terapias Regenerativas, en un art\u00edculo encabezado por Elisabeth Engel, revelan su compuesto de cristal de fosfato c\u00e1lcico\/PLA que estimula la movilizaci\u00f3n y diferenciaci\u00f3n de las c\u00e9lulas progenitoras endoteliales – las que se convierten en las c\u00e9lulas que componen el revestimiento de los vasos sangu\u00edneos.<\/p>\n

\u00abEn la medicina regenerativa, la reparaci\u00f3n tisular exitosa depende de poder recrear el medio adecuado, de forma que el biomaterial no s\u00f3lo act\u00fae como andamio para el tejido nuevo, sino que tambi\u00e9n contribuya a la activaci\u00f3n del proceso de regeneraci\u00f3n,\u00bb explica Elisabeth. \u00abHemos comprendido la importancia del micromedio local en la determinaci\u00f3n de lo que les sucede a las c\u00e9lulas gracias a recientes avances en la comprensi\u00f3n de la biolog\u00eda de las c\u00e9lulas madre y la mecanosensaci\u00f3n. Teniendo esto en cuenta, hemos conseguido desarrollar un biomaterial bioactivo y biodegradable que imita un micromedio como el de la regeneraci\u00f3n \u00f3sea que activa las se\u00f1ales necesarias para guiar el proceso regenerativo.\u00bb<\/p>\n

Su compuesto de bajo coste y f\u00e1cil elaboraci\u00f3n env\u00eda se\u00f1ales bioqu\u00edmicas y mec\u00e1nicas para activar dos v\u00edas de se\u00f1alizaci\u00f3n celular que ponen en marcha las c\u00e9lulas madre endoteliales provenientes de la m\u00e9dula \u00f3sea. Con el tiempo, se dirigen al lugar correcto, se diferencian en el tipo correcto de c\u00e9lulas y empiezan a ramificarse en las estructuras arb\u00f3reas que asociamos con los vasos sangu\u00edneos.<\/p>\n

Es la primera vez que se ha demostrado que un compuesto que contiene un cristal bioactivo y biodegradable est\u00e1 directamente implicado en la angiog\u00e9nesis y la diferenciaci\u00f3n de c\u00e9lulas progenitoras endoteliales. Adem\u00e1s de ofrecer nuevas y excitantes oportunidades terap\u00e9uticas para las aproximaciones a la vascularizaci\u00f3n basadas en los biomateriales y aplicaciones m\u00e9dicas, el descubrimiento ayudar\u00e1 a los investigadores a construir un modelo de las interacciones biol\u00f3gicas subyacentes en la interfaz c\u00e9lula-material para contribuir al dise\u00f1o racional de m\u00e1s biomateriales pro-angiog\u00e9nicos inteligentes.<\/p>\n

El art\u00edculo se publica esta semana en la revista eCells and Materials<\/em> (eCM), una revista especializada en c\u00e9lulas y biomateriales para el tejido musculoesquel\u00e9tico.<\/p>\n

Pie de foto: micrograf\u00eda SEM de CPEs en andamios de PLA\/G5 tras 7 d\u00edas de cultivo. Asteriscos: cristal de G5. Flecha: c\u00e9lulas progenitoras endoteliales.<\/span><\/p>\n

—
A. Aguirre, A. Gonz\u00e1lez, M. Navarro, \u00d3. Casta\u00f1o, J. A. Planell & E. Engel (2012). Control of microenvironmental cues with a smart biomaterial composite promotes endothelial progenitor cell angiog\u00e9nesis.<\/a> Eur Cell Mater., 24 July 2012<\/p>\n","protected":false},"excerpt":{"rendered":"

Investigadores del IBEC han dado en el blanco con la creaci\u00f3n de un nuevo biomaterial \u00abinteligente\u00bb que activa la angiog\u00e9nesis al proporcionar las se\u00f1ales bioqu\u00edmicas y mec\u00e1nicas necesarias para que empiece el proceso.<\/p>\n","protected":false},"author":4,"featured_media":6566,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[97],"tags":[],"post_formats":[],"class_list":["post-6571","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias-de-investigacion"],"yoast_head":"\nUn biomaterial inteligente favorece la angiog\u00e9nesis - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/es\/un-biomaterial-inteligente-favorece-la-angiogenesis\/\" 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