{"id":6769,"date":"2012-12-20T10:23:18","date_gmt":"2012-12-20T10:23:18","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/new\/una-estrategia-prometedora-para-combatir-la-malaria\/"},"modified":"2015-01-08T15:14:22","modified_gmt":"2015-01-08T15:14:22","slug":"una-estrategia-prometedora-para-combatir-la-malaria","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/es\/una-estrategia-prometedora-para-combatir-la-malaria\/","title":{"rendered":"Una estrategia prometedora para combatir la malaria"},"content":{"rendered":"<p>En el art\u00edculo \u201cDemonstration of specific binding of heparin to <em>Plasmodium falciparum<\/em>-infected vs non-infected red blood cells by single-molecule force spectroscopy\u201d, por Valle-Delgado, Urb\u00e1n y Fern\u00e0ndez-Busquets, publicado en el \u00faltimo n\u00famero de la revista <em>Nanoscale<\/em>, los investigadores se centraron en los cambios en la estructura de las c\u00e9lulas  rojas sangu\u00edneas (RBCs) infectadas por el par\u00e1sito de la malaria Plasmodium falciparum. <\/p>\n<p><span class=\"caption\">Imagen: La adhesi\u00f3n de la heparina a los eritrocitos infectados por el par\u00e1sito de la malaria, el <em>Plasmodium falciparum<\/em>, ha sido demostrada por la espectroscopia de fuerza at\u00f3mica de mol\u00e9culas individuales.<\/span><\/p>\n<p>No s\u00f3lo los RBCs parasitados (pRBCs) tienen m\u00e1s probabilidades de adherirse a los gl\u00f3bulos rojos normales y a otras c\u00e9lulas como ellos, formando c\u00famulos llamados rosetas, sino que tambi\u00e9n se pueden adherir a las paredes de los capilares, estrech\u00e1ndolos. Esto es caracter\u00edstico de la malaria grave y puede ser mortal. Se sabe que una prote\u00edna particular que se expresa en la superficie de las pRBCs, la PfEMP1, est\u00e1 implicada en facilitar su adhesi\u00f3n entre s\u00ed y con las paredes de los capilares, y perturbar esta prote\u00edna podr\u00eda ayudar a prevenirla.<\/p>\n<p>\u201cUsamos heparina, un glicosaminoglicano (GAG, un tipo de polisac\u00e1rido), junto con pRBCs, como modelo para estudiar las interacciones GAG-pRBC a nivel de mol\u00e9culas individuales por primera vez,\u201d diu el Dr. Xavier Fern\u00e0ndez-Busquets, uno de los investigadores s\u00e9nior del grupo de Nanobioingenier\u00eda. \u201cUsando microscop\u00eda de fluorescencia, selecci\u00f3n celular asistida por fluorescencia, y espectroscopia de potencia de mol\u00e9culas individuales, descubrimos que la heparina se liga espec\u00edficamente con las RBCs infectadas, pero no con las que est\u00e1n libres de infecci\u00f3n.\u201d<\/p>\n<p>Esto podr\u00eda permitir el desarrollo de terapias antimalarianas espec\u00edficas para las pRBCs basadas en la heparina o una mol\u00e9cula similar como elemento activo. \u00abPodr\u00eda ser una aproximaci\u00f3n mucho m\u00e1s barata que la alternativa de usar anticuerpos,\u00bb dice Xavier. \u00abEsto es especialmente importante ya que la malaria se da principalmente en los pa\u00edses en desarrollo.\u00bb<\/p>\n<p>&#8212;<\/p>\n<p><strong>IBEC en los Medios: <\/strong>La revista ha seleccionado este art\u00edculo \u2018candente\u2019 para aparecer en su pack de prensa semanal de la Royal Society of Chemistry Publishing, que se envia a periodistas cient\u00edficos. Tambi\u00e9n ha aparecido un art\u00edculo sobre esta investigaci\u00f3n en la secci\u00f3n de noticias online del <em>Chemistry World<\/em> (<a href=\"http:\/\/www.rsc.org\/ChemistryWorld\" target=\"_blank\">www.rsc.org\/ChemistryWorld<\/a>), y aparece en el blog y la pagina web de la revista en <a href=\"http:\/\/blogs.rsc.org\/nr\" target=\"_blank\">http:\/\/blogs.rsc.org\/nr<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<h3><img decoding=\"async\" class=\"left size-full wp-image-6764 lazyload\" data-src=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2012\/12\/tocrevision_2sm.jpg\" border=\"0\" width=\"350\" data-srcset=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2012\/12\/tocrevision_2sm.jpg 300w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2012\/12\/tocrevision_2sm-250x125.jpg 250w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2012\/12\/tocrevision_2sm-150x75.jpg 150w\" data-sizes=\"(max-width: 300px) 100vw, 300px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 300px; --smush-placeholder-aspect-ratio: 300\/150;\" \/>Un art\u00edculo publicado por el grupo de Nanobioingenier\u00eda revela una nueva estrategia para el tratamiento localizado de la malaria que no se basa en el uso de costosos anticuerpos.<\/h3>\n","protected":false},"author":4,"featured_media":6764,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[97],"tags":[],"post_formats":[],"class_list":["post-6769","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias-de-investigacion"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Una estrategia prometedora para combatir la malaria - Institute for 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