{"id":68049,"date":"2019-09-03T13:29:08","date_gmt":"2019-09-03T11:29:08","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=68049"},"modified":"2020-06-15T13:00:24","modified_gmt":"2020-06-15T11:00:24","slug":"investigadores-del-ibec-desarrollan-una-plataforma-de-bioingenieria-para-detectar-moleculas-proinflamatorias-en-trastornos-musculares","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/es\/investigadores-del-ibec-desarrollan-una-plataforma-de-bioingenieria-para-detectar-moleculas-proinflamatorias-en-trastornos-musculares\/","title":{"rendered":"Investigadores del IBEC desarrollan una plataforma de bioingenier\u00eda para detectar mol\u00e9culas proinflamatorias en trastornos musculares"},"content":{"rendered":"<figure id=\"attachment_68056\" aria-describedby=\"caption-attachment-68056\" style=\"width: 490px\" class=\"wp-caption alignleft\"><img decoding=\"async\" class=\"size-full wp-image-68056 lazyload\" data-src=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2019\/09\/Figura1.jpg\" alt=\"\" width=\"500\" height=\"332\" data-srcset=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2019\/09\/Figura1.jpg 500w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2019\/09\/Figura1-300x199.jpg 300w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2019\/09\/Figura1-196x130.jpg 196w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2019\/09\/Figura1-150x100.jpg 150w\" data-sizes=\"(max-width: 500px) 100vw, 500px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 500px; --smush-placeholder-aspect-ratio: 500\/332;\" \/><figcaption id=\"caption-attachment-68056\" class=\"wp-caption-text\">Schematic overview of the configuration and function of the muscle-on-a-chip. The flow passes through the microdevice where 3D SM tissue is electrically (ITO-IDA electrodes) or biologically (LPS) stimulated. As a consequence of this stimulation cytokines are secreted and detected in situ by the sensing platform which allows its quantification.<\/figcaption><\/figure>\n<p>En este contexto, la comprensi\u00f3n de la din\u00e1mica de secreci\u00f3n de prote\u00ednas de los tejidos es un factor cr\u00edtico para avanzar hacia una mejor detecci\u00f3n de anomal\u00edas y nuevos tratamientos para enfermedades como la distrofia muscular de Duchenne y la miopat\u00eda inflamatoria. Sin embargo, la determinaci\u00f3n de la velocidad de liberaci\u00f3n de tales mol\u00e9culas de un tejido in vivo representa un desaf\u00edo importante, debido a las contribuciones incontroladas de otros tejidos.<\/p>\n<p>Ahora, investigadores del IBEC han desarrollado una plataforma que permite localizar la fuente de citoquinas. Despu\u00e9s de cultivar tejidos biomim\u00e9ticos en 3D, los investigadores conectaron el \u00abm\u00fasculo en un chip\u00bb a una plataforma de detecci\u00f3n de prote\u00ednas de alta sensibilidad con el fin de medir su actividad biol\u00f3gica.<\/p>\n<p>Mediante este enfoque novedoso, los cient\u00edficos pueden monitorizar la secreci\u00f3n temporal de las mol\u00e9culas IL-6 y TNF\u2014\u03b1 resultantes de la estimulaci\u00f3n el\u00e9ctrica y qu\u00edmica de los tejidos musculares esquel\u00e9ticos.<\/p>\n<p>Seg\u00fan los autores, esta metodolog\u00eda podr\u00eda contribuir no s\u00f3lo a una mejor comprensi\u00f3n de la contribuci\u00f3n de\u00a0 las mol\u00e9culas IL-6 y TNF-\u03b1 en el proceso de inflamaci\u00f3n relacionada en el m\u00fasculo, sino tambi\u00e9n a futuros estudios de trastornos metab\u00f3licos . Esta revolucionaria tecnolog\u00eda se puede exportar a cualquier entorno de laboratorio y puede tener un gran impacto en el proceso de detecci\u00f3n de drogas para cualquier sistema de \u00f3rganos.<\/p>\n<p><strong>Art\u00edculo de referencia; <\/strong>M. A. Ortega, X. Fern\u00e1ndez-Garibay, A. G. Casta\u00f1o, F. De Chiara, <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2590137019300159#!\" target=\"_blank\" rel=\"noopener noreferrer\">A. Hern\u00e1ndez-Albors<\/a>, J. Balaguer-Trias and J. Ramon-Azcon. Muscle-on-a-chip with an on-site multiplexed biosensing system for in situ monitoring of secreted IL-6 and TNF-\u03b1. <em>Lab Chip, 2019,19, 2568-2580. 10.1039\/C9LC00285E.<\/em><\/p>\n<p><strong>Persona de contacto para m\u00e1s informaci\u00f3n: \u00c0ngels L\u00f3pez, Departamento de Comunicaci\u00f3n. <\/strong><\/p>\n<p><strong>E-Mail: <\/strong><a href=\"mailto:alopez@ibecbarcelona.eu\">alopez@ibecbarcelona.eu<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<h3>El grupo Biosensores para la bioingenier\u00eda liderado por Javier Ram\u00f3n ha desarrollado una plataforma de detecci\u00f3n para captar in situ las mol\u00e9culas proinflamatorias secretadas por los tejidos, conocidas como citoquinas. Esta nueva metodolog\u00eda abre una nueva puerta para la comprensi\u00f3n de los trastornos metab\u00f3licos presentes en las enfermedades musculares, as\u00ed como el desarrollo de aplicaciones de detecci\u00f3n de drogas. <\/h3>\n<\/p>\n<p>A pesar de que el 40% de la masa corporal total es tejido muscular esquel\u00e9tico, seg\u00fan la Asociaci\u00f3n M\u00e9dica Estadounidense, no existe un perfil de m\u00e9dico cl\u00ednico especializado en el tratamiento de enfermedades musculares. Es precisamente en esta \u00e1rea que, desde hace unos a\u00f1os, el grupo de investigaci\u00f3n del Dr. Javier Ram\u00f3n en IBEC trabaja para llenar la brecha entre trastornos musculares y terapias m\u00e9dicas espec\u00edficas. <\/p>\n","protected":false},"author":4,"featured_media":68056,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[97],"tags":[1130],"post_formats":[],"class_list":["post-68049","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias-de-investigacion","tag-javier-ramon-es"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Investigadores del IBEC desarrollan una plataforma de bioingenier\u00eda para detectar mol\u00e9culas proinflamatorias en trastornos musculares - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/es\/investigadores-del-ibec-desarrollan-una-plataforma-de-bioingenieria-para-detectar-moleculas-proinflamatorias-en-trastornos-musculares\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Investigadores del IBEC desarrollan una plataforma de bioingenier\u00eda para detectar mol\u00e9culas proinflamatorias en trastornos musculares - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"El grupo Biosensores para la bioingenier\u00eda liderado por Javier Ram\u00f3n ha desarrollado una plataforma de detecci\u00f3n para captar in situ las mol\u00e9culas proinflamatorias secretadas por los tejidos, conocidas como citoquinas. Esta nueva metodolog\u00eda abre una nueva puerta para la comprensi\u00f3n de los trastornos metab\u00f3licos presentes en las enfermedades musculares, as\u00ed como el desarrollo de aplicaciones de detecci\u00f3n de drogas.   A pesar de que el 40% de la masa corporal total es tejido muscular esquel\u00e9tico, seg\u00fan la Asociaci\u00f3n M\u00e9dica Estadounidense, no existe un perfil de m\u00e9dico cl\u00ednico especializado en el tratamiento de enfermedades musculares. Es precisamente en esta \u00e1rea que, desde hace unos a\u00f1os, el grupo de investigaci\u00f3n del Dr. Javier Ram\u00f3n en IBEC trabaja para llenar la brecha entre trastornos musculares y terapias m\u00e9dicas espec\u00edficas.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ibecbarcelona.eu\/es\/investigadores-del-ibec-desarrollan-una-plataforma-de-bioingenieria-para-detectar-moleculas-proinflamatorias-en-trastornos-musculares\/\" \/>\n<meta property=\"og:site_name\" content=\"Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"article:published_time\" content=\"2019-09-03T11:29:08+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-06-15T11:00:24+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2019\/09\/Figura1.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"500\" \/>\n\t<meta property=\"og:image:height\" content=\"332\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"\u00c0ngels L\u00f3pez\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"\u00c0ngels L\u00f3pez\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/investigadores-del-ibec-desarrollan-una-plataforma-de-bioingenieria-para-detectar-moleculas-proinflamatorias-en-trastornos-musculares\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/investigadores-del-ibec-desarrollan-una-plataforma-de-bioingenieria-para-detectar-moleculas-proinflamatorias-en-trastornos-musculares\\\/\"},\"author\":{\"name\":\"\u00c0ngels L\u00f3pez\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/person\\\/c212c6b589546130be67986b9290e2b8\"},\"headline\":\"Investigadores del IBEC desarrollan una plataforma de bioingenier\u00eda para detectar mol\u00e9culas proinflamatorias en trastornos musculares\",\"datePublished\":\"2019-09-03T11:29:08+00:00\",\"dateModified\":\"2020-06-15T11:00:24+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/investigadores-del-ibec-desarrollan-una-plataforma-de-bioingenieria-para-detectar-moleculas-proinflamatorias-en-trastornos-musculares\\\/\"},\"wordCount\":393,\"publisher\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/investigadores-del-ibec-desarrollan-una-plataforma-de-bioingenieria-para-detectar-moleculas-proinflamatorias-en-trastornos-musculares\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2019\\\/09\\\/Figura1.jpg\",\"keywords\":[\"Javier Ram\u00f3n\"],\"articleSection\":[\"Noticias de investigaci\u00f3n\"],\"inLanguage\":\"es\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/investigadores-del-ibec-desarrollan-una-plataforma-de-bioingenieria-para-detectar-moleculas-proinflamatorias-en-trastornos-musculares\\\/\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/investigadores-del-ibec-desarrollan-una-plataforma-de-bioingenieria-para-detectar-moleculas-proinflamatorias-en-trastornos-musculares\\\/\",\"name\":\"Investigadores del IBEC desarrollan una plataforma de bioingenier\u00eda para detectar mol\u00e9culas proinflamatorias en trastornos musculares - 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