{"id":71500,"date":"2020-01-28T15:20:32","date_gmt":"2020-01-28T14:20:32","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=71500"},"modified":"2020-06-15T12:57:09","modified_gmt":"2020-06-15T10:57:09","slug":"nuevos-avances-en-la-mejora-del-diseno-de-farmacos-contra-la-taupatia-globular-glial","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/es\/nuevos-avances-en-la-mejora-del-diseno-de-farmacos-contra-la-taupatia-globular-glial\/","title":{"rendered":"Nuevos avances en la mejora del dise\u00f1o de f\u00e1rmacos contra la taupat\u00eda globular glial"},"content":{"rendered":"<p>Las taupat\u00edas se caracterizan por la acumulaci\u00f3n de la prote\u00edna tau fosforilada, es decir unida a grupos fosfato. Esta acumulaci\u00f3n provoca la disfunci\u00f3n de las prote\u00ednas y acaba da\u00f1ando las c\u00e9lulas. Dentro de este grupo de enfermedades, encontramos las taupat\u00edas globulares gliales, como el Alzheimer, que se distinguen por la aglomeraci\u00f3n de la prote\u00edna tau fosforilada en neuronas, formando agregados en las c\u00e9lulas gliales.<\/p>\n<p>En este estudio se pone en evidencia que no s\u00f3lo tau es la causante de estas patolog\u00edas como se cre\u00eda hasta el momento, sino que muchas otras prote\u00ednas se encuentran anormalmente fosforiladas, lo que conduce a la formaci\u00f3n de estos dep\u00f3sitos proteicos. Estos hallazgos demuestran tambi\u00e9n que estas acumulaciones no solo afectan a las neuronas, sino tambi\u00e9n a las c\u00e9lulas gliales que las acompa\u00f1an, lo que puede provocar que ciertas determinadas conexiones neuronales se rompan. Adem\u00e1s, estos agregados son capaces de viajar de una neurona a otra, provocando la propagaci\u00f3n del da\u00f1o hacia las c\u00e9lulas sanas, como si de una infecci\u00f3n se tratara.<\/p>\n<p>Para realizar el estudio, se han analizado los casos de varios pacientes con este tipo de taupat\u00eda, gracias a la participaci\u00f3n del Hospital de Navarra, que se ha encargado de analizar los niveles de fosforilaci\u00f3n y de las prote\u00ednas implicadas.<\/p>\n<p>Estos descubrimientos abren una nueva v\u00eda de investigaci\u00f3n para el dise\u00f1o de nuevos f\u00e1rmacos que paren la progresi\u00f3n de la enfermedad. Para ello, primero habr\u00e1 que tener en cuenta que la adici\u00f3n de grupos fosfato no solo afecta a tau, sino que tambi\u00e9n a otras prote\u00ednas y, por otro lado, no s\u00f3lo est\u00e1n implicadas las neuronas sino tambi\u00e9n las c\u00e9lulas gliares, que adem\u00e1s favorecen la transmisi\u00f3n y expansi\u00f3n de la enfermedad.<\/p>\n<p>Este estudio ha sido financiado por el Ministerio de Economia y Competitividad, la Fundaci\u00f3n \u201cLa Caixa\u201d y \u201cEuropean Regional Development Fund\u201d.<\/p>\n<p><strong>Art\u00edculo de referencia:\u00a0<\/strong><em>Isidro Ferrer, Pol Andr\u00e9s-Benito, Maria Victoria Zelaya, Maria Elena Erro Aguirre, Margarita Carmona, Karina Aus\u00edn, Mercedes Lach\u00e9n-Montes, Joaqu\u00edn Fern\u00e1ndez-Irigoyen, Enrique Santamar\u00eda &amp; Jos\u00e9 Antonio del Rio.<\/em> <strong><a href=\"https:\/\/link.springer.com\/article\/10.1007%2Fs00401-019-02122-9\" target=\"_blank\" rel=\"noopener noreferrer\">Familial globular glial tauopathy linked to MAPT mutations: molecular neuropathology and seeding capacity of a prototypical mixed neuronal and glial tauopathy<\/a><\/strong><em>Acta Neuropathologica (2020) DOI: https:\/\/doi.org\/10.1007\/s00401-019-02122-9\u00a0<\/em><\/p>\n<p><strong>Fuente: <\/strong><a href=\"http:\/\/www.idibell.cat\/en\/whats-on\/noticies\/new-aspects-globular-glial-tauopathy-could-help-design-more-effective-drugs\" target=\"_blank\" rel=\"noopener noreferrer\">IDIBELL\u00a0<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<h3><img decoding=\"async\" class=\"alignnone size-full wp-image-66903 lazyload\" data-src=\"http:\/\/www.ibecbarcelona.eu\/wp-content\/uploads\/2019\/06\/delrio_ibec.jpg\" alt=\"\" width=\"500\" height=\"398\" data-srcset=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2019\/06\/delrio_ibec.jpg 500w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2019\/06\/delrio_ibec-300x239.jpg 300w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2019\/06\/delrio_ibec-163x130.jpg 163w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2019\/06\/delrio_ibec-150x119.jpg 150w\" data-sizes=\"(max-width: 500px) 100vw, 500px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 500px; --smush-placeholder-aspect-ratio: 500\/398;\" \/>Jos\u00e9 Antonio del R\u00edo, investigador principal en el Instiuto de Bioingenier\u00eda de Catalu\u00f1a (IBEC) junto con el Dr. Isidre Ferrer del Instituto de Investigaciones Biom\u00e9dicas de Bellvitge (IDIBELL) han liderado un estudio en el que han descubierto que la patolog\u00eda que muestran los pacientes con taupatia globular glial es debida a la generaci\u00f3n de dep\u00f3sitos proteicos da\u00f1inos para las neuronas y las c\u00e9lulas gliales. <\/h3>\n","protected":false},"author":4,"featured_media":66903,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[97],"tags":[1133,142,846,845],"post_formats":[],"class_list":["post-71500","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias-de-investigacion","tag-jose-antonio-del-rio-es","tag-neurodegeneracion","tag-neurologia","tag-taupatia-globular-glial"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Nuevos avances en la mejora del dise\u00f1o de f\u00e1rmacos contra la taupat\u00eda globular glial - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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