{"id":7237,"date":"2013-03-21T10:59:18","date_gmt":"2013-03-21T10:59:18","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/new\/cambio-de-marcha-en-la-comprension-de-la-funcion-celular\/"},"modified":"2015-10-20T14:43:44","modified_gmt":"2015-10-20T14:43:44","slug":"cambio-de-marcha-en-la-comprension-de-la-funcion-celular","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/es\/cambio-de-marcha-en-la-comprension-de-la-funcion-celular\/","title":{"rendered":"Cambio de marcha en la comprensi\u00f3n de la funci\u00f3n celular"},"content":{"rendered":"

Imaginad que conduc\u00eds un coche por una carretera de monta\u00f1a y os encontr\u00e1is con una fuerte pendiente. Para aseguraros de que podr\u00e9is subirla, reduc\u00eds la marcha para mejorar la transmisi\u00f3n de fuerza del motor a las ruedas.<\/p>\n

Quiz\u00e1 pens\u00e9is que las c\u00e9lulas de nuestro cuerpo no tienen mucho que ver con los coches, pero resulta que las c\u00e9lulas usan un mecanismo muy similar para transmitir las fuerzas que les permiten cumplir importantes funciones como la migraci\u00f3n celular, mover los m\u00fasculos o simplemente mantener la integridad de los tejidos. Pero en lugar de usar marchas, las c\u00e9lulas emplean mol\u00e9culas.<\/p>\n

C\u00e9lula marcada con los dos tipos de mol\u00e9culas, alfa-actinina (verde) y talina (rojo). Otra mol\u00e9cula, integrina, aparece en azul.<\/h6>\n

Un equipo dirigido por el Dr. Pere Roca-Cusachs del Institut de Bioenginyeria de Catalunya (IBEC), ha descubierto c\u00f3mo las c\u00e9lulas usan dos de estas mol\u00e9culas, la talina y la alfa-actinina, para conectar y transmitir fuerzas a lo que las rodea. Usando nanotecnolog\u00edas que pueden detectar y aplicar fuerzas sobre las c\u00e9lulas, los investigadores han descubierto un mecanismo indispensable por el cual las c\u00e9lulas \u201ccambian de marcha\u201d usando una mol\u00e9cula o la otra, regulando la transmisi\u00f3n de fuerzas y su conexi\u00f3n con su entorno.<\/p>\n

\u201cComo las fuerzas celulares son esenciales para procesos tan importantes como el desarrollo embrionario o la cicatrizaci\u00f3n de heridas, y tambi\u00e9n para procesos indeseables como la progresi\u00f3n del c\u00e1ncer, este descubrimiento representa un paso importante en nuestra comprensi\u00f3n de la funci\u00f3n celular, con implicaciones tanto para la salud como para la enfermedad,\u201d explica Pere.<\/p>\n

—<\/p>\n

Roca-Cusachs, P., del Rio, A., Faucher, E., Gauthier, N.C., Biais, N. & Sheetz, M.P. (2013). Integrin-dependent force transmission to the extracellular matrix by \u03b1-actinin triggers adhesion maturation<\/a>. PNAS<\/em>, 110(15): E1361-70<\/p>\n","protected":false},"excerpt":{"rendered":"

Un investigador del IBEC y sus colaboradores descubren el papel crucial de dos mol\u00e9culas al permitir que las c\u00e9lulas se comuniquen con su entorno. <\/h3>\n","protected":false},"author":4,"featured_media":7232,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[97],"tags":[],"post_formats":[],"class_list":["post-7237","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias-de-investigacion"],"yoast_head":"\nCambio de marcha en la comprensi\u00f3n de la funci\u00f3n celular - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/es\/cambio-de-marcha-en-la-comprension-de-la-funcion-celular\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" 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