{"id":72410,"date":"2019-07-12T16:24:07","date_gmt":"2019-07-12T14:24:07","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=72410"},"modified":"2020-03-13T11:13:10","modified_gmt":"2020-03-13T10:13:10","slug":"una-nueva-tecnologia-de-cultivo-para-ensayos-funcionales-intestinales","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/es\/una-nueva-tecnologia-de-cultivo-para-ensayos-funcionales-intestinales\/","title":{"rendered":"Una nueva tecnolog\u00eda de cultivo para ensayos funcionales intestinales"},"content":{"rendered":"

Investigadores del IBEC dirigidos por la Dra. Elena Mart\u00ednez, en colaboraci\u00f3n con el IRB, describieron en un art\u00edculo publicado en Scientific Reports un m\u00e9todo simple para generar monocapas epiteliales intestinales en pel\u00edculas delgadas de Matrigel\u00ae.<\/p>\n

Estas monocapas replican la composici\u00f3n y organizaci\u00f3n celular in vivo en un formato de cultivo de tejidos que permite el acceso independiente a los compartimientos apical y basolateral. Como caracter\u00edstica \u00fanica, estas monocapas epiteliales forman barreras epiteliales funcionales con una superficie accesible y propiedades el\u00e9ctricas fisiol\u00f3gicamente relevantes.<\/p>\n

Esta tecnolog\u00eda ofrece un m\u00e9todo actualizado de cultivo intestinal fisiol\u00f3gicamente relevante compatible con ensayos funcionales como la absorci\u00f3n de f\u00e1rmacos, el tr\u00e1fico intracelular y los ensayos de interacci\u00f3n microbio-epitelio.<\/p>\n

Art\u00edculo de referencia: <\/strong>Altay<\/a> et al. (2019). Self-organized intestinal epithelial monolayers in crypt and villus-like domains show effective barrier function. Scientific Reports<\/em><\/a> volume9, 10140.<\/p>\n","protected":false},"excerpt":{"rendered":"

\"\"Durante la \u00faltima d\u00e9cada, los organoides intestinales se han convertido en una herramienta crucial para estudiar la biolog\u00eda intestinal in vitro. Sin embargo, su geometr\u00eda en forma de esfera limita el acceso de luz del organoide, lo que dificulta su uso en muchos experimentos funcionales en los que se requiere acceso independiente a los diferentes lados del epitelio.<\/h3>\n","protected":false},"author":4,"featured_media":72384,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[97],"tags":[825],"post_formats":[],"class_list":["post-72410","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias-de-investigacion","tag-elena-martinez-es"],"yoast_head":"\nUna nueva tecnolog\u00eda de cultivo para ensayos funcionales intestinales - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/es\/una-nueva-tecnologia-de-cultivo-para-ensayos-funcionales-intestinales\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Una nueva tecnolog\u00eda de cultivo para ensayos funcionales intestinales - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Durante la \u00faltima d\u00e9cada, los organoides intestinales se han convertido en una herramienta crucial para estudiar la biolog\u00eda intestinal in vitro. Sin embargo, su geometr\u00eda en forma de esfera limita el acceso de luz del organoide, lo que dificulta su uso en muchos experimentos funcionales en los que se requiere acceso independiente a los diferentes lados del epitelio.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ibecbarcelona.eu\/es\/una-nueva-tecnologia-de-cultivo-para-ensayos-funcionales-intestinales\/\" \/>\n<meta property=\"og:site_name\" content=\"Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"article:published_time\" content=\"2019-07-12T14:24:07+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-03-13T10:13:10+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2020\/03\/EMartinez_web.png\" \/>\n\t<meta property=\"og:image:width\" content=\"500\" \/>\n\t<meta property=\"og:image:height\" content=\"219\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"\u00c0ngels L\u00f3pez\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"\u00c0ngels L\u00f3pez\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minuto\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/una-nueva-tecnologia-de-cultivo-para-ensayos-funcionales-intestinales\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/una-nueva-tecnologia-de-cultivo-para-ensayos-funcionales-intestinales\\\/\"},\"author\":{\"name\":\"\u00c0ngels L\u00f3pez\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/person\\\/c212c6b589546130be67986b9290e2b8\"},\"headline\":\"Una nueva tecnolog\u00eda de cultivo para ensayos funcionales intestinales\",\"datePublished\":\"2019-07-12T14:24:07+00:00\",\"dateModified\":\"2020-03-13T10:13:10+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/una-nueva-tecnologia-de-cultivo-para-ensayos-funcionales-intestinales\\\/\"},\"wordCount\":161,\"publisher\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/una-nueva-tecnologia-de-cultivo-para-ensayos-funcionales-intestinales\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2020\\\/03\\\/EMartinez_web.png\",\"keywords\":[\"Elena Martinez\"],\"articleSection\":[\"Noticias de investigaci\u00f3n\"],\"inLanguage\":\"es\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/una-nueva-tecnologia-de-cultivo-para-ensayos-funcionales-intestinales\\\/\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/una-nueva-tecnologia-de-cultivo-para-ensayos-funcionales-intestinales\\\/\",\"name\":\"Una nueva tecnolog\u00eda de cultivo para ensayos funcionales intestinales - 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