{"id":73765,"date":"2020-04-28T10:48:28","date_gmt":"2020-04-28T08:48:28","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=73765"},"modified":"2020-04-28T10:45:03","modified_gmt":"2020-04-28T08:45:03","slug":"pericord-el-bioimplante-capaz-de-reparar-el-tejido-cardiaco-en-pacientes","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/es\/pericord-el-bioimplante-capaz-de-reparar-el-tejido-cardiaco-en-pacientes\/","title":{"rendered":"PeriCord, el bioimplante capaz de reparar el tejido card\u00edaco en pacientes"},"content":{"rendered":"

M\u00e1s concretamente, los m\u00e9dicos introdujeron un\u00a0<\/span>bioimplante<\/span>\u00a0llamado\u00a0<\/span>PeriCord<\/span><\/i>\u00a0a un paciente de 63 a\u00f1os que hab\u00eda sufrido un infarto.<\/span>\u00a0<\/span><\/p>\n

Tres meses m\u00e1s tarde, el tama\u00f1o de la cicatriz provocada por el infarto se hab\u00eda reducido significativamente -alrededor de un 9% -, tal y como hab\u00edan previsto los expertos bas\u00e1ndose en estudios precl\u00ednicos con cerdos.<\/span>\u00a0<\/span><\/p>\n

Los detalles de esta nueva terapia se recogen en un art\u00edculo cient\u00edfico publicado recientemente en la revista\u00a0<\/span>EBioMedicine<\/span><\/i>\u00a0<\/span><\/i>de la prestigiosa\u00a0<\/span>The<\/span><\/i>\u00a0<\/span><\/i>Lancet<\/span><\/i>. En este documento, los autores\u00a0<\/span>exponen<\/span>\u00a0que para la elaboraci\u00f3n del\u00a0<\/span>bioimplante<\/span>\u00a0-bautizado con el nombre de\u00a0<\/span>PeriCord<\/span><\/i>\u00a0en honor a los dos componentes que lo forman: el pericardio y el cord\u00f3n umbilical- tu<\/span>vieron que incorporar las\u00a0<\/span>c\u00e9lulas madre en una matriz de pericardio que deb\u00eda actuar como veh\u00edculo que permitiera la aplicaci\u00f3n de las c\u00e9lulas que conten\u00eda directamente sobre la zona infartada.<\/span>\u00a0<\/span><\/p>\n

Este\u00a0<\/span>bioimplante<\/span>\u00a0presenta una dureza comparable\u00a0<\/span>a<\/span>\u00a0la de un ventr\u00edculo, est\u00e1 formado de pericardio humano\u00a0<\/span>descelularizado<\/span>\u00a0y enriquecido con c\u00e9lulas madre\u00a0<\/span>mesenquimales<\/span>, que proceden del cord\u00f3n umbilical. Estas c\u00e9lulas se caracterizan por poseer, adem\u00e1s de una gran plasticidad y propiedades\u00a0<\/span>inmunomoduladoras<\/span>\u00a0y antiinflamatorias importantes, la capacidad de regenerar\u00a0<\/span>los tejidos, lo que explica la reducci\u00f3n del tama\u00f1o de la cicatriz provocada por el infarto.<\/span>\u00a0<\/span><\/p>\n

\"\"<\/a><\/p>\n

Seg\u00fan los expertos, liderados por el profesor de la UB Daniel Navajas, que\u00a0<\/span>dirige<\/span>\u00a0<\/span>el Grupo de Biomec\u00e1nica Celular y Respiratoria<\/span>\u00a0del IBEC, el gran reto era transformar un prototipo de 2 cm<\/span>2<\/span>\u00a0utilizado en el modelo precl\u00ednico probado con cerdos en un\u00a0<\/span>bioimplante<\/span>\u00a0de 16 cm<\/span>2<\/span>\u00a0y cumplir todos los requisitos de seguridad y normativas para\u00a0<\/span>su\u00a0<\/span>uso<\/span>\u00a0en<\/span>\u00a0humano<\/span>s<\/span>.<\/span>\u00a0<\/span><\/p>\n

Un infarto de miocardio puede condicionar la capacidad del paciente de llevar a cabo actividades de la vida diaria, as\u00ed como su calidad y esperanza de vida. En casos extremos, se puede llegar a necesitar un trasplante de coraz\u00f3n,\u00a0<\/span>aunque<\/span>\u00a0lo m\u00e1s frecuente es que quede una cicatriz residual que dilata el coraz\u00f3n y hace que el paciente evolucione hacia una insuficiencia card\u00edaca. Este perfil de enfermos son los que se podr\u00edan beneficiar de manera significativa de esta nueva tecnolog\u00eda.<\/span>\u00a0<\/span><\/p>\n

Este proyecto ha sido posible gracias al apoyo del Departamento de Salud de la Generalidad de Catalu\u00f1a mediante las ayudas PERIS, El Instituto de Salud Carlos III y \u00abla\u00a0<\/span>Caixa<\/span>\u00ab.<\/span>\u00a0<\/span><\/p>\n

Art\u00edculo de referencia:<\/span><\/b> Prat-Vidal et al. <\/span>First<\/span>-in-<\/span>human<\/span>PeriCord<\/span>\u00a0<\/span>cardiac<\/span>\u00a0<\/span>bioimplant<\/span>:\u00a0<\/span>Scalability<\/span>\u00a0and GMP\u00a0<\/span>manufacturing<\/span>\u00a0of\u00a0<\/span>an<\/span>\u00a0<\/span>allogeneic<\/span>\u00a0<\/span>engineered<\/span>\u00a0<\/span>tissue<\/span>\u00a0<\/span>graft<\/span><\/a>,\u00a0<\/span>EBioMedicine<\/span>,\u00a0Abril\u00a02020.<\/span> DOI: https:\/\/doi.org\/10.1016\/j.ebiom.2020.102729\u00a0<\/span><\/p>\n

M\u00e1s informaci\u00f3n:<\/span><\/b>\u00a0<\/span>Bioingenieros<\/span>\u00a0IBEC contribuyen a un implante para el coraz\u00f3n<\/span><\/a>\u00a0<\/span><\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

\"\"La revista \u00abEBioMedicine\u00bb de \u00abThe Lancet\u00bb acaba de publicar el procedimiento que permiti\u00f3 la creaci\u00f3n, el a\u00f1o pasado, del \u201cPeriCord\u201d, el primer bioimplante card\u00edaco humano, en cuya elaboraci\u00f3n el Instituto de Bioingenier\u00eda de Catalu\u00f1a (IBEC) tuvo un papel clave.<\/h3>\n

En mayo de 2019, una colaboraci\u00f3n entre el Hospital Germans Trias i Pujol de Badalona, \u200b\u200bel Banco de Sangre y Tejidos (BST) y el IBEC hizo posible en Barcelona un nuevo avance para los pacientes cardiacos gracias a una f\u00f3rmula sencilla: combinar medicina, ciencia e ingenier\u00eda.<\/p>\n","protected":false},"author":4,"featured_media":73770,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[97],"tags":[753,754,546,523],"post_formats":[],"class_list":["post-73765","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias-de-investigacion","tag-bioimplante-es","tag-daniel-navajas-es","tag-regeneracion","tag-regeneracion-de-corazon"],"yoast_head":"\nPeriCord, el bioimplante capaz de reparar el tejido card\u00edaco en pacientes - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/es\/pericord-el-bioimplante-capaz-de-reparar-el-tejido-cardiaco-en-pacientes\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"PeriCord, el bioimplante capaz de reparar el tejido card\u00edaco en pacientes - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"La revista "EBioMedicine" de "The Lancet" acaba de publicar el procedimiento que permiti\u00f3 la creaci\u00f3n, el a\u00f1o pasado, del \u201cPeriCord\u201d, el primer bioimplante card\u00edaco humano, en cuya elaboraci\u00f3n el Instituto de Bioingenier\u00eda de Catalu\u00f1a (IBEC) tuvo un papel clave. 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