{"id":74330,"date":"2020-05-26T10:00:20","date_gmt":"2020-05-26T08:00:20","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=74330"},"modified":"2020-06-15T12:54:38","modified_gmt":"2020-06-15T10:54:38","slug":"investigadores-del-ibec-hallan-una-nueva-forma-de-transportar-eficazmente-farmacos-al-cerebro","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/es\/investigadores-del-ibec-hallan-una-nueva-forma-de-transportar-eficazmente-farmacos-al-cerebro\/","title":{"rendered":"Investigadores del IBEC hallan una nueva forma de transportar eficazmente f\u00e1rmacos al cerebro"},"content":{"rendered":"

Al poco tiempo tras su administraci\u00f3n en ratones de laboratorio, las nanopart\u00edculas recubiertas con este anticuerpo hab\u00edan conseguido llegar al cerebro atravesando la barrera hematoencef\u00e1lica, que separa el torrente sangu\u00edneo de este tejido y se caracteriza por tener una permeabilidad altamente selectiva.<\/p>\n

La barrera hematoencef\u00e1lica act\u00faa de manera eficaz al proteger al cerebro de pat\u00f3genos y sustancias toxicas que puedan circular en la sangre, lo que hace que las enfermedades que afectan al cerebro sean dif\u00edciles de tratar, pues el 98% de los f\u00e1rmacos no pueden cruzarla. En cambio, substancias naturales como nutrientes, hormonas y c\u00e9lulas del sistema inmune s\u00ed pueden atravesarla y entrar al cerebro desde el flujo sangu\u00edneo.<\/p>\n

La estrategia dise\u00f1ada por el grupo de la Dra. Muro para superar esta barrera se basa precisamente en el uso de ICAM-1, que es una de las dianas usadas por las c\u00e9lulas del sistema inmune para atravesar esta barrera.<\/p>\n

Seg\u00fan apuntan los investigadores del IBEC y la Universidad de Maryland, se trata de un hallazgo muy significativo, pues podr\u00eda ayudar a optimizar la liberaci\u00f3n de f\u00e1rmacos a trav\u00e9s del endotelio, que es el tejido que recubre la parte interna de los vasos sangu\u00edneos. De esta forma, los f\u00e1rmacos podr\u00edan penetrar eficazmente la barrera hematoencef\u00e1lica y entrar al cerebro.<\/p>\n

\u201cEn este trabajo demostramos como esta estrategia ayuda a transportar al cerebro de animales de experimentaci\u00f3n un f\u00e1rmaco que no puede pasar por s\u00ed mismo a este \u00f3rgano, lo que podr\u00eda ofrecer un nuevo tratamiento para la enfermedad de Niemann-Pick tipo A, un s\u00edndrome neurodegenerativo cong\u00e9nito e incurable, sin tratamiento actual, expone Silvia Muro, la autora principal del trabajo.<\/p>\n

En este sentido, la experta a\u00f1ade que \u201csiguiendo esta misma estrategia, el sistema podr\u00eda adaptarse para liberar otros f\u00e1rmacos y ayudar a pacientes de otras enfermedades que afectan al cerebro, como el Alzheimer, Parkinson, meningitis o glioblastoma\u201d. De hecho, la investigadora est\u00e1 inmersa en otro proyecto del IBEC cuyo objetivo es obtener nuevos anticuerpos para avanzar esta estrategia hacia la cl\u00ednica.<\/p>\n

La Profesora Silvia Muro se incorpor\u00f3 al IBEC a finales de 2017 para liderar el grupo \u2018Targeted Therapeutics and Nanodevices\u2019, que investiga c\u00f3mo dise\u00f1ar nanotransportadores cargados con medicamentos que pueden usar las rutas naturales de transporte en el organismo para tratar enfermedades neurodegenerativas, cardiovasculares, metab\u00f3licas o el c\u00e1ncer.<\/p>\n

Art\u00edculo de referencia: <\/strong>Rachel L.Manthe, Maximilian Loeck, Tridib Bhowmick, Melani Solomon, Silvia Muro. \u00abIntertwined mechanisms define transport of anti-ICAM nanocarriers across the endothelium and brain delivery of a therapeutic enzyme\u00bb.\u00a0Journal of Controlled Release<\/em>,\u00a0August 2020. DOI: https:\/\/doi.org\/10.1016\/j.jconrel.2020.05.009\u00a0<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

\"\"Un grupo internacional de investigadores liderados por la profesora ICREA Silvia Muro del Instituto de Bioingenier\u00eda de Catalunya (IBEC) y la Universidad de Maryland (Estados Unidos) ha identificado una nueva forma de transportar f\u00e1rmacos al cerebro, uno de los grandes desaf\u00edos de la ciencia farmac\u00e9utica actual, lo que podr\u00eda ayudar a dise\u00f1ar nuevos tratamientos para enfermedades neurol\u00f3gicas tales como el Parkinson o el Alzheimer. <\/h3>\n

Para la elaboraci\u00f3n del trabajo, publicado esta semana en la prestigiosa revista Journal of Controlled Release, los expertos unieron un anticuerpo capaz de reconocer la prote\u00edna ICAM-1 \u2013una mol\u00e9cula expresada en la superficie de los vasos sangu\u00edneos- a una serie de nanopart\u00edculas polim\u00e9ricas que pueden transportar un f\u00e1rmaco e inyectarlo por v\u00eda intravenosa.<\/p>\n","protected":false},"author":4,"featured_media":74331,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[97],"tags":[1007,1008,1126],"post_formats":[],"class_list":["post-74330","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias-de-investigacion","tag-barrera-hematoencefalica","tag-cerebro","tag-silvia-muro-es"],"yoast_head":"\nInvestigadores del IBEC hallan una nueva forma de transportar eficazmente f\u00e1rmacos al cerebro - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/es\/investigadores-del-ibec-hallan-una-nueva-forma-de-transportar-eficazmente-farmacos-al-cerebro\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Investigadores del IBEC hallan una nueva forma de transportar eficazmente f\u00e1rmacos al cerebro - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Un grupo internacional de investigadores liderados por la profesora ICREA Silvia Muro del Instituto de Bioingenier\u00eda de Catalunya (IBEC) y la Universidad de Maryland (Estados Unidos) ha identificado una nueva forma de transportar f\u00e1rmacos al cerebro, uno de los grandes desaf\u00edos de la ciencia farmac\u00e9utica actual, lo que podr\u00eda ayudar a dise\u00f1ar nuevos tratamientos para enfermedades neurol\u00f3gicas tales como el Parkinson o el Alzheimer. Para la elaboraci\u00f3n del trabajo, publicado esta semana en la prestigiosa revista Journal of Controlled Release, los expertos unieron un anticuerpo capaz de reconocer la prote\u00edna ICAM-1 \u2013una mol\u00e9cula expresada en la superficie de los vasos sangu\u00edneos- a una serie de nanopart\u00edculas polim\u00e9ricas que pueden transportar un f\u00e1rmaco e inyectarlo por v\u00eda intravenosa.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ibecbarcelona.eu\/es\/investigadores-del-ibec-hallan-una-nueva-forma-de-transportar-eficazmente-farmacos-al-cerebro\/\" \/>\n<meta property=\"og:site_name\" content=\"Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"article:published_time\" content=\"2020-05-26T08:00:20+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-06-15T10:54:38+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2017\/11\/silviamuro1.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"500\" \/>\n\t<meta property=\"og:image:height\" content=\"369\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"\u00c0ngels L\u00f3pez\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"\u00c0ngels L\u00f3pez\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/investigadores-del-ibec-hallan-una-nueva-forma-de-transportar-eficazmente-farmacos-al-cerebro\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/investigadores-del-ibec-hallan-una-nueva-forma-de-transportar-eficazmente-farmacos-al-cerebro\\\/\"},\"author\":{\"name\":\"\u00c0ngels L\u00f3pez\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/person\\\/c212c6b589546130be67986b9290e2b8\"},\"headline\":\"Investigadores del IBEC hallan una nueva forma de transportar eficazmente f\u00e1rmacos al cerebro\",\"datePublished\":\"2020-05-26T08:00:20+00:00\",\"dateModified\":\"2020-06-15T10:54:38+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/investigadores-del-ibec-hallan-una-nueva-forma-de-transportar-eficazmente-farmacos-al-cerebro\\\/\"},\"wordCount\":467,\"publisher\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/investigadores-del-ibec-hallan-una-nueva-forma-de-transportar-eficazmente-farmacos-al-cerebro\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2017\\\/11\\\/silviamuro1.jpg\",\"keywords\":[\"Barrera Hematoencef\u00e1lica\",\"Cerebro\",\"Silvia Muro\"],\"articleSection\":[\"Noticias de investigaci\u00f3n\"],\"inLanguage\":\"es\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/investigadores-del-ibec-hallan-una-nueva-forma-de-transportar-eficazmente-farmacos-al-cerebro\\\/\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/investigadores-del-ibec-hallan-una-nueva-forma-de-transportar-eficazmente-farmacos-al-cerebro\\\/\",\"name\":\"Investigadores del IBEC hallan una nueva forma de transportar eficazmente f\u00e1rmacos al cerebro - 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